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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Implicit Versus Explicit Nature of Science Instruction: An Explicit Response to Palmquist and Finley 显示文摘 | Bell R L Lederman N G Abd-EI-Khalick F | 1998 | Journal of Research in Science Teaching1998，35，： | 1 |
| 3 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 4 | Use of molecular markers in a breeding program for Corus florida显示文摘 | Trigiano R N Schlarbaum S E Bell L M | 1996 | Proc Southern Nurseryman’s Res Conf1996，41，： | 1 |
| 5 | Diversity and sensitivity of epiphytes to oxides of nitrogen in London 显示文摘 | Davies L Bates J W Bell J N B | 2007 | Environmental Pollution2007，146，1： | 1 |
| 6 | Modulation of drug permeation through interpolymer complexed hydrogels for drug delivery applications显示文摘 | Bell C L Peppas N A | 1996 | J Controlled Release1996，39，： | 1 |
| 7 | Water,solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol)显示文摘 | Bell C L Peppas N A | 1996 | Biomaterials1996，17，： | 1 |
| 8 | Accumulation of hydroxyproline-rich glycoprotein mRNAs in response to fungal elicitor and infection显示文摘 | Showalter A M Bell J N Cramer C L | 1985 | Proc Natl Acad Sci USA1985，82，19： | 1 |
| 9 | Maillard reaction as influenced by buffer type and concentration显示文摘 | Bell L N | | 0，，1： | 1 |
| 10 | Comparison of un- certainty sources for climate change impacts: flood frequency in England 显示文摘 | Kay A L Davies H N Bell V A Jones R G | 2009 | Climatic Change2009，92，： | 1 |
| 11 | Relationshipbetween adipose tissue insulin resistance and liver histol-ogy in nonalcoholic steatohepatitis : A pioglitazone versusvitamin E versus placebo for the treatment of nondiabeticpatients with nonalcoholic steatohepatitis trial follow-upstudy 显示文摘 | Bell L N Wang J Muralidharan S | 2012 | Hepatology2012，56，4： | 1 |
| 12 | Glyeine loss and maillard browning as related to the glass transition in a model food system显示文摘 | BELL L N TOUMA D E WHITE K L | 1998 | J Food Sci1998，63，4： | 1 |
| 13 | A fast multigrid algorithm for mesh deformation 显示文摘 | Shi L Yu Y Z Bell N etal | 2006 | ACM Transactions on Graphics2006，25，3： | 1 |
| 14 | Epidemiology of idiosyncratic drug - induced liver injury 显示文摘 | Bell L N Chalasani N | 2009 | Semin Liver Dis2009，29，： | 1 |
| 15 | Phosphorus speciation in temperate basaltic grassland soils by solution 31 p NMR spectroscopy显示文摘 | Murphy P N C Bell A Turner B L | 2009 | European Journal of Soil Science2009，60，4： | 1 |
| 16 | Novel powder-processing methods for advanced ceramics显示文摘 | Sigmund W M Bell N S Bergstrom L | 2000 | J Am Ceram Soc2000，83，7： | 1 |
| 17 | Maillard reaction as influenced by buffer type and concentration显示文摘 | Bell L N | 1997 | Food Chemistry1997，59，1： | 1 |
| 18 | Molecular dynamics study of methane and xenon in silicalite显示文摘 | June R L Bell A T Theodorou D N | 1990 | J Phys Chem1990，94，21： | 1 |
| 19 | MRI & MRS assess- ment of the role of the tumour microenvironment in response to therapy显示文摘 | Bell L K Ainsworth N L Lee S H etal | 2011 | NMR Biomed2011，24，6： | 1 |
| 20 | Continuous renal replacement therapy in children after cardiac surgery显示文摘 | Maria José Santiago Jesús López-Herce Javier Urbano Maria José Solana Jimena del Castillo Amelia Sánchez Jose María Bellón | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，2： | 1 |
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