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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Image Indexing Using Compressed Color Histogram显示文摘 | BERENS J FINLAYSON G D | 2000 | IEEE Trans on Vision Image and Signal Processing2000，147，4： | 1 |
| 3 | Amplification of the inosinate dehydrogenase fene in Trypanosoma brucei gambiense due to an increase in chromosome copy number 显示文摘 | Wilson K Berens R Sifri C D | 1994 | J Biol Chem1994，269，28： | 1 |
| 4 | Mini- and micro-screws for temporary skeletal anchorage in orthodontic therapy显示文摘 | Berens A Wiechmann D Dempf R | 2006 | J Orofac Orthop2006，67，6： | 1 |
| 5 | Purine metabolism in Leishmania donovani and Leishmania braziliensis 显示文摘 | Marr J J Berens R L Nelson D J | 1978 | Bioehim Biophys Aeta1978，544，： | 1 |
| 6 | Comparison of MRI and discography in the diagnosis of lumbar degenerative disc dis- ease显示文摘 | Birney T J White J J Jr Berens D | 1992 | J Spinal Disord1992，5，4： | 1 |
| 7 | Image indexing using compressed color histograms 显示文摘 | BERENS J FINLAYSON G D QIU G | 2000 | lEE Proc Vi- sion Image Signal Process2000，147，4： | 1 |
| 8 | Thermodynamics and quantum corrections from molecular dynamics for liquid water显示文摘 | Berens P H Mackay D H J White G M | 1983 | J Chem Phys1983，79，： | 1 |
| 9 | Dynamic properties of lymphatic pathways for the absorption of cerebrospinal fluid显示文摘 | BRINKER T LUDEMANN W BERENS VON RAUTENFELD D | 1997 | Acta Neuropathol1997，94，5： | 1 |
| 10 | Purine and pyrimidine salvage pathways in Leishmania donovani显示文摘 | LA FON S W NELSON D J BERENS R L | 1982 | Biothem Pharmacol1982，31，2： | 1 |
| 11 | Desmoplakin and Plakoglobin-specific markers of lymphatic vessels in the skin?显示文摘 | FEDELE C BERENS D RAUTENFELD V | 2004 | Anat Histol Embryol2004，33，3： | 1 |
| 12 | Purine metabolism in Leishmania donovani and Leishmania braziliensis显示文摘 | MARR J J BERENS R L NELSON D J | 1978 | Biochim Biophys Acta1978，544，2： | 1 |
| 13 | Topography, ultra- structure and phagocytic capacity of avian lymph nodes显示文摘 | Berens von Rautenfeld D Budras K D | 1983 | Cell tissue Res1983，228，2： | 1 |
| 14 | Recent findings on the angioarchitecture of the lymph vessel system of human skin显示文摘 | LUBACH D LUDEMANN W BERENS V | 1996 | Br J Dermatol1996，135，： | 1 |
| 15 | Use of a single VH family and long CDR3s in the variable region of cattle Ig heavy chains显示文摘 | Berens S J Wylie D E Lopez O J | 1997 | International immunology1997，9，1： | 1 |
| 16 | Desmoplakin and Plakoglobin-specific markers of lymphatic vessels in the skin? 显示文摘 | Fedele C Berens D Rautenfeld V | 2004 | Anat Histol Embryol2004，33，3： | 1 |
| 17 | Dynamic properties of lymphatic pathways for the absorption of cerebrospinal fluid显示文摘 | Ludemann W Berens von Rautenfeld D | 1997 | Acta Neuropathol(Berl)1997，94，： | 1 |
| 18 | Ultrastructure of the cerebrospinal fluid outflow along the optic nerve into the lymphatic system显示文摘 | Ldemann W Berens von Rautenfeld D Samii M | 2005 | Childs Nerv Syst2005，21，2： | 1 |
| 19 | Renal osteodystrophy with leontiasis ossea deformity显示文摘 | Reidy JM Motamedi K Berens D | | 0，，05： | 1 |
| 20 | The possible role of the initial lymph vessels of the skin during metastasis of maliguant tumors 显示文摘 | Lubach D Berens yon Rautenfeld D Kaiser HE | 1992 | In Vivo1992，6，4： | 1 |
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