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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Shippers' ecological buying behavior towards logistics services in France显示文摘 | BERND P DORIN M | 2011 | International Journal of Logisties: Research & Applications2011，14，6： | 1 |
| 4 | Time domain modeling of axisymmetric wave propagation in isotropic elastic media with CEFIT-cylindrical elastodynamic finite integration technique 显示文摘 | FRANK S BERND K ALEXANDER P | 2001 | Journal of Computational Acoustics2001，9，3： | 1 |
| 5 | Analysis of the dynamics in microactuators using high-speed cine photomicrography显示文摘 | Christian Rembe Bernd Tibken Eberhard P Hofer | 2001 | Journal of Microelectromechanical System2001，10，1： | 1 |
| 6 | Cell density-dependent regulation:Basic principles and effects on the virulence of Gram-positive cocci显示文摘 | Andreas P Bernd K | 2004 | Int J Infect Dis2004，8，2： | 1 |
| 7 | The prospects for willow plantations for wastewater treatment in Sweden显示文摘 | B?rjesson P Berndes G | | 0，，： | 1 |
| 8 | Permutation entropy, a natural complexity measure for time series 显示文摘 | CHRISTOPH B BERND P | 2002 | Physical Review Letters2002，88，17： | 1 |
| 9 | Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial显示文摘 | Thomas K?hnlein Wolfram Windisch Dieter K?hler Anna Drabik Jens Geiseler Sylvia Hartl Ortrud Karg Gerhard Laier-Groeneveld Stefano Nava Bernd Sch?nhofer Bernd Schucher Karl Wegscheider Carl P Criée Tobias Welte | 2014 | The Lancet Respiratory Medicine2014，，9： | 1 |
| 10 | Severe leukopenia in a rheumatoid arthritis patient treated with a methotrexate/leflunomide combination 显示文摘 | TOTH P BERND R | 2014 | Rev Bras Reumatol2014，5，2： | 1 |
| 11 | Permutation entropy:a natural complexity measure for time series显示文摘 | CHRISTOPH B BERND P | 2002 | Physical Review Letters2002，88，17： | 1 |
| 12 | The structures of the active center in dark-adapted bacteriorhodopsin by solution-state NMR spectroscopy显示文摘 | HEIKO P BERND S ANTONIUSTER L | 2002 | PANS2002，99，15： | 1 |
| 13 | TRPV4 calcium entry channel: A paradigrm for gating diversity 显示文摘 | Bernd N Jolis V Jean P | 2004 | Am J Physiol2004，286，： | 1 |
| 14 | Evolution of organic matter and nitrogen during co-composting of olive mill wastewater with solid organic wastes显示文摘 | Paredes C Roig A Bernd M P | 2000 | Biol Fertil Soils2000，32，： | 1 |
| 15 | Cerebral resuscitation potentials for cardiac arrest显示文摘 | Safar P Behringer W Bernd W B | 2002 | Crit Care Med2002，30，4： | 1 |
| 16 | Plastic deformation with reversible peak broadening in nanocrystalline nickel显示文摘 | BUDROVIC Z van SWYGENHOVEN H DERLET P M van PETEGEM S BERND S | 2004 | Science2004，304，： | 1 |
| 17 | Neural networks for multiuser detection in code-division multiple-access communications显示文摘 | Bernd P P Orsak G | 1992 | IEEE Trans on Commun1992，40，： | 1 |
| 18 | Aspartokinase genes lysCα and lysCβ overlap and are adjacent to the aspartate β-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum显示文摘 | J?rn Kalinowski Bernd Bachmann Georg Thierbach Alfred Pühler | 1990 | MGG Molecular & General Genetics1990，，3： | 1 |
| 19 | Ultrasonic density sensor for liquids显示文摘 | Pǜttmer A Peter Hauptmann Bernd Henning | 2000 | IEEE Ultrasonics Symposium2000，47，1： | 1 |
| 20 | Virtual Labyrinthoscopy: Visualization of the Inner Ear with Interactive Direct Volume Rendering显示文摘 | Bernd FT Hastreiter P Eberhardt K | 2000 | RadioGraphics2000，20，2： | 1 |
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