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| 1 | Current developments in pediatric liver transplantation显示文摘In 1953, the pioneer of human orthotopic liver transplantation(LT), Thomas E Starzl, was the first to attempt an orthotopic liver transplant into a 3 years old patient suffering from biliary atresia. Thus, the first LT in humans was attempted in a disease, which, up until today, remains the main indication for pediatric LT(p LT). During the last sixty years, refinements in diagnostics and surgical technique, the introduction of new immunosuppressive medications and improvements in perioperative pediatric care have established LT as routine procedure for childhood acute and chronic liver failure as well as inherited liver diseases. In contrast to adult recipients, p LT differs greatly in indications for LT, allocation practice, surgical technique, immunosuppression and postoperative life-long aftercare. Many aspects are focus of ongoing preclinical and clinical research. The present review gives an overview of current developments and the clinical outcome of p LT, with a focus on alternatives to full-size deceased-donor organ transplantation. | Christina Hackl Hans J Schlitt Martin Loss Birgit Knoppke Michael Melter | 2015 | World Journal of Hepatology2015，7，11： | 13 |
| 2 | Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations显示文摘Constipation and fecal impaction are frequent and distressing complaints in pediatric gastroenterology. Especially in neurologically handicapped children, treatment of severe forms of slow-transit constipation (STC) can be difficult. In the majority of cases, STC is of unknown etiology. However, in recent years, there is growing evidence that interstitial cells of Cajal (ICCs), which serve as electrical pacemakers and generate spontaneous electrical slow waves in the gastrointestinal tract, might play an important role in the pathophysiology of STC. It remains unclear whether morphological ICC alterations seen in affected patients are based on congenital developmental anomalies, or whether they are a consequence of long-term constipation with secondary damage of the gastrointestinal nervous system. To the best of our knowledge, we present the first case of a patient with histological alterations in ICC morphology who displayed multiple alterations of c-kit at the level of mRNA. The protein encoded by c-kit is the receptor tyrosine kinase Kit (CD117), which is crucial for development and function of ICCs. Therefore, these findings provide a new explanation for congenital alterations of ICC development that result in gastrointestinal motility disorders. | Christian Breuer Jun Oh Gerhard J Molderings Michael Schemann Birgit Kuch Ertan Mayatepek Rüdiger Adam | 2010 | World Journal of Gastroenterology2010，16，34： | 7 |
| 3 | Liver transplantation for malignancy:current treatment strategies and future perspectives显示文摘In 1967,Starzl et al performed the first successful liver transplantation for a patient diagnosed with hepatoblastoma.In the following,liver transplantation was considered ideal for complete tumor resection and potential cure from primary hepatic malignancies.Several reports of liver transplantation for primary and metastatic liver cancer however showed disappointing results and the strategy was soon dismissed.In1996,Mazzaferro et al introduced the Milan criteria,offering liver transplantation to patients diagnosed with limited hepatocellular carcinoma.Since then,liver transplantation for malignant disease is an ongoing subject of preclinical and clinical research.In this context,several aspects must be considered:(1)Given the shortage of deceased-donor organs,long-term overall and disease free survival should be comparable with results obtained in patients transplanted for nonmalignant disease;(2)In this regard,living-donor liver transplantation may in selected patients help to solve the ethical dilemma of optimal individual patient treatment vs organ allocation justice;and(3)Ongoing research focusing on perioperative therapy and antiproliferative immunosuppressive regimens may further reduce tumor recurrence in patients transplanted for malignant disease and thus improve overall survival.The present review gives an overview of current indications and future perspectives of liver transplantation for malignant disease. | Christina Hackl Hans J Schlitt Gabriele I Kirchner Birgit Knoppke Martin Loss | 2014 | World Journal of Gastroenterology2014，20，18： | 7 |
| 4 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
| 5 | Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine显示文摘AIM: To investigate the effects of lubiprostone and Polyethylene Glycol 3350 (PEG) on mucosal barrier repair in ischemic-injured porcine intestine. METHODS: Ileum from 6 piglets (approximately 15 kg body weight) was subjected to ischemic conditions by occluding the local mesenteric circulation for 45 min in vivo. Ileal tissues from each pig were then harvested and mounted in Ussing chambers and bathed in oxygenated Ringer's solution in vitro. Intestinal barrier function was assessed by measuring transepithelial electrical resistance (TER) and mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Statistical analyses of data collected over a 120-min time course included 2-way ANOVA for the effects of time and treatment on indices of barrier function. RESULTS: Application of 1 μmol/L lubiprostone to the mucosal surface of ischemic-injured ileum in vitro induced significant elevations in TER compared to non-treated tissue. Lubiprostone also reduced mucosal-to-serosal fluxes of 3H-mannitol and 14C-inulin. Alternatively,application of a polyethylene laxative (PEG,20 mmol/L) to the mucosal surface of ischemic tissues significantly increased flux of 3H-mannitol and 14C-inulin. CONCLUSION: This experiment demonstrates that lubiprostone stimulates recovery of barrier function in ischemic intestinal tissues whereas the PEG laxative had deleterious effects on mucosal repair. These results suggest that,unlike osmotic laxatives,lubiprostone stimulates repair of the injured intestinal barrier. | Adam J Moeser Prashant K Nighot Birgit Roerig Ryuji Ueno Anthony T Blikslager | 2008 | World Journal of Gastroenterology2008，14，39： | 2 |
| 6 | Efficiency of cellular delivery of antisense peptide nucleic acid by electroporation depends on charge and electroporation geometry显示文摘 | Metre J Birgit A L Peter E N | | 0，，01： | 1 |
| 7 | Diffusion of Nickel,Strontium,Lodine,Cesium and Americium in loosely compacted bentonite at high pH显示文摘 | Birgit C Bor J E Torstenfelt | 1988 | Radiochimica Acta1988，44，： | 1 |
| 8 | Diffusion of Nicke, Strontium, Lodine, Cesium and Americium in Loosely Compacted Bentonite at High pH显示文摘 | Birgit C Bor J E Yorstenfelt | 1988 | Radiochimica Acta1988，44，： | 1 |
| 9 | Identification of genes potentially involved in rupture of human atherosclerotic plaques显示文摘 | Birgit C G F Kitty B J M C Ron L J N | 2001 | Circ Res2001，89，6： | 1 |
| 10 | Gastric Inhibitory Polypeptide and Glucagon-Like Peptide-1 in the Pathogenesis of Type 2 Diabetes显示文摘 | Michael A Nauck Birgit Baller Juris J Meier | 2004 | Diabetes2004，53，： | 1 |
| 11 | Analysis of sequence and pathogenic properties of two variants of encephalomyocarditis virus differing in a single amino acid in VP1显示文摘 | Birgit Nelsen-Salz Albert Zimmermann Stephan Wickert Georg Arnold Arne Botta Hans J Eggers Johannes P Kruppenbacher | 1996 | Virus Research1996，，2： | 1 |
| 12 | Significant histamine formation in tuna (Thunnus albacares) at 2 ℃-effect of vacuum-and modified atmosphere-packaging on psychrotolerant bacteria显示文摘 | EMBORG J BIRGIT G L PAW D | 2005 | International Journal of Food Microbiology2005，101，3： | 1 |
| 13 | Scenario workshops and consensus conferences:towards more democratic decision -making显示文摘 | ANDERSEN I E BIRGIT J | 1999 | Science and Public Policy1999，26，5： | 1 |
| 14 | Assessment of melamine and cyanuric acid toxicity in eats显示文摘 | BIRGIT P ROBERT H P LINDA J L | 2007 | Journal of Veterinary Diagnostic Investigation2007，19，6： | 1 |
| 15 | Scenario workshops and consensus conferences:towards more democratic decision -making显示文摘 | ANDERSEN I E BIRGIT J | 1999 | Science and Public Policy1999，26，5： | 1 |
| 16 | Scenario workshops and consensus conferences:towards more democratic decision-making显示文摘 | ANDERSEN I E BIRGIT J | 1999 | Science and Public Policy1999，26，5： | 1 |
| 17 | Plant rhizodeposition — an important source for carbon turnover in soils显示文摘 | Birgit W.Hütsch JürgenAugustin WolfgangMerbach | 2002 | Bodenk2002，，4： | 1 |
| 18 | Scenario workshops and consensus conferences:towards more democratic decision-making显示文摘 | ANDERSEN I E BIRGIT J | 1999 | Science and Public Policy1999，26，5： | 1 |
| 19 | Single implants in the upper in- cisor region and their relationship to the adjacent teeth 显示文摘 | BIRGIT T JAN ) TORSTEN J | 1999 | Clin Oral Implants Res1999，10，5： | 1 |
| 20 | The Influence of Transformational Leadership on Employee Well-Being: Results From a Survey of Companies in the Information and Communication Technology Sector in Germany显示文摘 | Christine Jacobs Holger Pfaff Birgit Lehner Elke Driller Anika Nitzsche Brigitte Stieler-Lorenz Jürgen Wasem Julia Jung | 2013 | Journal of Occupational and Environmental Medicine2013，，7： | 1 |
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