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| 1 | Accurate and generalizable quantitative scoring of liver steatosis from ultrasound images via scalable deep learning显示文摘BACKGROUND Hepatic steatosis is a major cause of chronic liver disease.Two-dimensional(2D)ultrasound is the most widely used non-invasive tool for screening and monitoring,but associated diagnoses are highly subjective.AIM To develop a scalable deep learning(DL)algorithm for quantitative scoring of liver steatosis from 2D ultrasound images.METHODS Using multi-view ultrasound data from 3310 patients,19513 studies,and 228075 images from a retrospective cohort of patients received elastography,we trained a DL algorithm to diagnose steatosis stages(healthy,mild,moderate,or severe)from clinical ultrasound diagnoses.Performance was validated on two multiscanner unblinded and blinded(initially to DL developer)histology-proven cohorts(147 and 112 patients)with histopathology fatty cell percentage diagnoses and a subset with FibroScan diagnoses.We also quantified reliability across scanners and viewpoints.Results were evaluated using Bland-Altman and receiver operating characteristic(ROC)analysis.RESULTS The DL algorithm demonstrated repeatable measurements with a moderate number of images(three for each viewpoint)and high agreement across three premium ultrasound scanners.High diagnostic performance was observed across all viewpoints:Areas under the curve of the ROC to classify mild,moderate,and severe steatosis grades were 0.85,0.91,and 0.93,respectively.The DL algorithm outperformed or performed at least comparably to FibroScan control attenuation parameter(CAP)with statistically significant improvements for all levels on the unblinded histology-proven cohort and for“=severe”steatosis on the blinded histology-proven cohort.CONCLUSION The DL algorithm provides a reliable quantitative steatosis assessment across view and scanners on two multi-scanner cohorts.Diagnostic performance was high with comparable or better performance than the CAP. | Bowen Li Dar-In Tai Ke Yan Yi-Cheng Chen Cheng-Jen Chen Shiu-Feng Huang Tse-Hwa Hsu Wan-Ting Yu Jing Xiao Lu Le Adam P Harrison | 2022 | World Journal of Gastroenterology2022，28，22： | 2 |
| 2 | Alien limb syndrome and moya-moya disease显示文摘 | Bowen LE Watson RT | 2004 | Mov Disord2004，19，： | 1 |
| 3 | Design and function of novel superplasticizers for more durable high performance concrete (superplast project)显示文摘 | Yves F. Houst Paul Bowen Fran?ois Perche Annika Kauppi Pascal Borget Laurent Galmiche Jean-Fran?ois Le Meins Fran?oise Lafuma Robert J. Flatt Irene Schober Phil F.G. Banfill David S. Swift Bernt O. Myrvold Berit G. Petersen K?re Reknes | 2008 | Cement and Concrete Research2008，，10： | 1 |
| 4 | Acute nenrobe- havioral effects in rats from exposure to HFC 134a or CFC 12 显示文摘 | RITCHIE GD KIMMEL EC BOWEN LE | 2001 | Neurotoxicology2001，22，2： | 1 |
| 5 | Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge显示文摘 | Karaca K Bowen R Austgen LE | 2005 | Vaccine2005，3123，29： | 1 |
| 6 | Alien limb syndrome and moya-moya disease显示文摘 | Rabbani O Bowen LE Watson RT | 2004 | Mov Disord2004，19，11： | 1 |
| 7 | Acute neurobehavioral effects in rat from exposure to HFC134a or CFC12显示文摘 | Kimmel EC Bowen LE | 2001 | Neurotoxicology2001，22，2： | 1 |
| 8 | Alien limbsyndrome and Moyamoya disease 显示文摘 | Rabbani O Bowen LE Watson RT | 2004 | Mov Disord2004，19，11： | 1 |
| 9 | Recombinant canary-pox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge显示文摘 | Karaca K Bowen R Austgen LE | 2005 | Vaccine2005，23，29： | 1 |
| 10 | Mechanisms of T cell death in the liver:to Bim or not to Bim显示文摘 | Holz LE Bowen DG Rertolino P | | Digestive Diseases0，，： | 1 |
| 11 | Fabrication and mechanical behavior of 2D-C_(f)/Ta_(x)Hf_(1−x)C–SiC composites by a low-temperature and highly-efficient route显示文摘C_(f)/Ta_(x)Hf_(1−x)C–SiC composites are ideal thermal structural materials for service under extreme conditions of hypersonic vehicles.However,how to synthesize TaxHf1-xC powders and efficiently fabricate C_(f)/Ta_(x)Hf_(1−x)C–SiC composites still faces some challenges.Furthermore,mechanical properties and thermophysical properties of Ta_(x)Hf_(1−x)C vary with the composition,but not monotonically.In-depth analysis of mechanical behaviors of the C_(f)/Ta_(x)Hf_(1−x)C–SiC composites is extremely important for their development and applications.In this study,the Ta_(x)Hf_(1−x)C powders(x=0.2,0.5,0.8)were successfully synthesized via solid solution of TaC and HfC at a relatively low temperature of 1800℃,with a small amount of Si as an additive.Subsequently,the efficient fabrication of 2D-C_(f)/Ta_(x)Hf_(1−x)C–SiC composites was achieved by slurry impregnation and lamination(SIL)combined with precursor infiltration and pyrolysis(PIP).In addition,the mechanical behavior of the composites was investigated systematically.It is demonstrated that the composites present remarkable non-brittle fractures,including a large number of fiber pull out and interphase debonding.Also,the fracture failure involves a complex process of microcrack generation and propagation,matrix cracking,and layer fracture.Moreover,the interfacial bonding between the fibers and the matrix is enhanced as the Ta∶Hf ratio decreases from 4∶1 to 1∶4.As a result,C_(f)/Ta_(0.2)Hf_(0.8)C–SiC composites exhibit exceptional flexural strength of 437±19 MPa,improved by 46%compared with C_(f)/Ta_(0.8)Hf_(0.2)C–SiC(299±19 MPa).This study provides a new perception of design and fabrication of ultra-high-temperature ceramic(UHTC)matrix composites with high performance. | Xuegang Zou Dewei Ni Bowen Chen Feiyan Cai Le Gao Ping He Yusheng Ding Xiangyu Zhang Shaoming Dong | 2023 | Journal of Advanced Ceramics2023，12，10： | 0 |
| 12 | Surface reconstruction,modification and functionalization of natural diatomites for miniaturization of shaped heterogeneous catalysts显示文摘Since the discovery of mesoporous silica in 1990s,there have been numerous mesoporous silica-based nanomaterials developed for catalytic applications,aiming at enhanced catalytic activity and stability.Recently,there have also been considerable interests in endowing them with hierarchical porosities to overcome the diffusional limitation for those with long unimodal channels.Present processes of making mesoporous silica largely rely on chemical sources which are relatively expensive and impose environmental concerns on their processes.In this regard,it is desirable to develop hierarchical silica supports from natural minerals.Herein,we present a series of work on surface reconstruction,modification,and functionalization to produce diatomite-based catalysts with original morphology and macro-meso-micro porosities and to test their suitability as catalyst supports for both liquid-and gas-phase reactions.Two wet-chemical routes were developed to introduce mesoporosity to both amorphous and crystalline diatomites.Importantly,we have used computational modeling to affirm that the diatomite morphology can improve catalytic performance based on fluid dynamics simulations.Thus,one could obtain this type of catalysts from numerous natural diatoms that have inherently intricate morphologies and shapes in micrometer scale.In principle,such catalytic nanocomposites acting as miniaturized industrial catalysts could be employed in microfluidic reactors for process intensification. | Bowen Li Tian Wang Qiujian Le Runze Qin Yuxin Zhang Hua Chun Zeng | 2023 | Nano Materials Science2023，5，3： | 0 |
| 13 | Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury显示文摘Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion(I/R)injury.However,a genome-wide map of histone modifications and the underlying epigenetic signatures in myocardial I/R injury have not been established.Here,we integrated transcriptome and epigenome of histone modifications to characterize epigenetic signatures after I/R injury.Disease-specific histone mark alterations were mainly found in H3K27me3-,H3K27ac-,and H3K4me1-marked regions 24 and 48 h after I/R.Genes differentially modified by H3K27ac,H3K4me1 and H3K27me3 were involved in immune response,heart conduction or contraction,cytoskeleton,and angiogenesis.H3K27me3 and its methyltransferase polycomb repressor complex 2(PRC2)were upregulated in myocardial tissues after I/R.Upon selective inhibition of EZH2(the catalytic core of PRC2),the mice manifest improved cardiac function,enhanced angiogenesis,and reduced fibrosis.Further investigations confirmed that EZH2 inhibition regulated H3K27me3 modification of multiple pro-angiogenic genes and ultimately enhanced angiogenic properties in vivo and in vitro.This study delineates a landscape of histone modifications in myocardial I/R injury,and identifies H3K27me3 as a key epigenetic modifier in I/R process.The inhibition of H3K27me3 and its methyltransferase might be a potential strategy for myocardial I/R injury intervention. | Le Ni Bowen Lin Yanping Zhang Lingjie Hu Jianghua Lin Fengmei Fu Meiting Shen Can Li Lei Chen Jian Yang Dan Shi Yi-Han Chen | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 14 | Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring显示文摘Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and wearability.However,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial application.Herein,aflexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is pro-posed.The porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and NaHCO3.Due to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aflat pressure sensor without a porous MNA structure.Finite-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the sen-sor.In addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode structure.Most importantly,it was found that the sensor could accurately monitor the motion of afinger,wrist joint,arm,face,abdomen,eye,and Adam’s apple.Furthermore,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s apple.Finally,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×tion.Compared to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer. | Jiahui Xu Minghao Wang Minyi Jin Siyan Shang Chuner Ni Yili Hu Xun Sun Jun Xu Bowen Ji Le Li Yuhua Cheng Gaofeng Wang | 2024 | Nanotechnology and Precision Engineering2024，7，1： | 0 |
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