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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Effect of PCs superplasticizers on the rheological properties and hydration process of slag-blended cement pastes显示文摘 | M Palacios F Puertas P Bowen | 2009 | J Mater Sci2009，，44： | 1 |
| 3 | Consideration for the utilization of smart sensors显示文摘 | Smith G Bowen M | 1995 | Sensors and Actuators (A)1995，46，： | 1 |
| 4 | Increased expression of GPI-specific phospholipase D in mouse models of type 1 diabetes显示文摘 | Deeq M A Bowen R F williams M D | 2001 | Am J Physiol Endocrinol Metab2001，281，： | 1 |
| 5 | Novel insecticidal toxins from the bacterinm Photorhabdus luminescens显示文摘 | Bowen D J Rochelean T A Blackburn M | 1998 | Science1998，6，： | 1 |
| 6 | The role of pro - inflammatory cytokines in cancer treatment - induced alimen- tary tract mucositis: pathobiology, animal models and cytotoxic drugs 显示文摘 | LOGAN R M STRINGER A M BOWEN J M | 2007 | Cancer Treatment Rev2007，33，5： | 1 |
| 7 | Biomarkers of chemothera-py -induced diarrhoea : a clinical study of intestinal microbiome altera-tions ,inflammation and circulating matrix metalloproteinases 显示文摘 | Stringer A M Al - Dasooqi N Bowen | 2013 | Sup-portive Care in Cancer2013，21，7： | 1 |
| 8 | Adhensive bonding of various materials to hard tooth tissues: XIII synthesis of a polyfunctional surface-active amine accelerator 显示文摘 | Antonucci J M Bowen R L | 1977 | J Dent Res1977，56，8： | 1 |
| 9 | Novel insecticidal toxins from the bacterium Photorhabdus luminescens显示文摘 | Bowen D J Rochelle T A Blackburn M | 1998 | Science1998，6，： | 1 |
| 10 | Fast digi- tal image inpainting显示文摘 | OL1VEIRA M BOWEN B MCKENNA R | 2001 | Imaging and Image Processing (VI- IP2001 )2001，，9： | 1 |
| 11 | Thermoelectric Power Sensor for Microwave Applications by Commercial CMOS Fabrication显示文摘 | Gaitan M Bowen E D | 1997 | IEEE Electron Device Letters1997，18，9： | 1 |
| 12 | Incompressible Porous Media by Use of the Theory of Mixtures显示文摘 | | 1980 | Int J Engng Sci1980，18，： | 1 |
| 13 | Identification and characterization of a low phytic acid wheat 显示文摘 | Guttieri M Bowen D Dorsch JA | 2004 | Crop Science2004，44，： | 1 |
| 14 | HLA is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells 显示文摘 | King A Allan DS Bowen M | 2000 | Eur J Immunol2000，30，6： | 1 |
| 15 | Analyst Coverageand the Cost of Raising Equity Capital: Evidence fromUnderpricing of Seasoned Equity Offerings 显示文摘 | Bowen R M Chen Xia Cheng Qiang | 2008 | ContemporaryAccounting Research2008，25，3： | 1 |
| 16 | Primary pollutant prediction from integrated thermo fluid-kinetic pulse combustor models显示文摘 | Heravi H M Dawson J R Bowen P J | 2005 | Journal of Propulsion and Power2005，21，6： | 1 |
| 17 | Strontium and barium in plants and soils显示文摘 | Bowen H J M Dymond J A | 1995 | Proceedings of the Royal Society of London1995，144，： | 1 |
| 18 | Esterification does not impair lutein bioavailability in humans显示文摘 | BOWEN P E HERBST-ESPINOSA S M HUSSAIN E A | 2002 | J Nutr2002，132，： | 1 |
| 19 | Accounting discretion, corporate governance and firm performance显示文摘 | Bowen R M Rajgopal S Venkatachalam M | 2008 | Contemporary Accounting Research2008，25，2： | 1 |
| 20 | Reflectance spectro-scopic mapping of diagenetic heterogeneities and fluid-flowpathways in the Jurassic Navajo Sandstone显示文摘 | Bowen B Martini B A Chan M A | 2007 | AAPG Bulle-tin2007，91，2： | 1 |
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