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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Primary chemotherapy to avoid mastectomy in tumors with diameters of three centimeters or more 显示文摘 | Bonadonna G Veronesi U Brambilla C | 1990 | J Natl Cancer Inst1990，82，19： | 1 |
| 3 | Pri- mary chemotherapy in operable breast cancer:eight-year expe- rience at the Milan Cancer Institute显示文摘 | BONADONNA G VALAGUSSA P BRAMBILLA C | 1998 | J Clin Oncol1998，16，1： | 1 |
| 4 | Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells显示文摘 | Folini M Brambilla C Villa R | 2005 | Eur J Cancer2005，416，： | 1 |
| 5 | Primary che-motherapy in operable breast cancer:Eight-year experi-ence at the Milan Cancer Institute显示文摘 | Bonadonna G ValagussaP Brambilla C | 1998 | J Clin Oncol1998，16，1： | 1 |
| 6 | An effect of the PAI-1 4G/5G polymorphism on cholesterol levels may explain conflicting associations with myocardial infarction and stroke显示文摘 | Boncoraglio GB Bodini A Brambilla C | 2006 | Cerebrovasc Dis2006，22，23： | 1 |
| 7 | Toxicity of several important agricultural antibiotics to Anemia显示文摘 | MIGILORE L CIVITAREALE C BRAMBILLA G | 1997 | Water Research1997，31，7： | 1 |
| 8 | Pri- mary chemotherapy to avoid mastectomy in tumors with diame- ters of three centimeters or more显示文摘 | BONADONNA G VERONESI U BRAMBILLA C | 1990 | J Nat Cancer Inst1990，82，19： | 1 |
| 9 | Primary chemotherapy in operable breast cancer:eight-year experience at the Milan Cancer Institute显示文摘 | Bonadonna G Valagussa P Brambilla C | 1998 | J Clin Oncol1998，16，1： | 1 |
| 10 | Primary chemotherapy in operable breast cancer:eight-year experience at the milan cancer institute显示文摘 | Bonadonna G Valagussa P Brambilla C | 1998 | J Clin Oncol1998，16，1： | 1 |
| 11 | Metallocene catalyst supported on silica - magnesia xerogels for ethylene polymerization 显示文摘 | Rodrigo Brambilla Claudio Radtke Fernanda C S | 2010 | Applied Catalysis A : General2010，382，1： | 1 |
| 12 | Vinorelbine:an active,non cross-resislaru drug in advanced breast cancer:Results from a phaseⅡstudy显示文摘 | Terenziani M Demicheli R Brambilla C | 1996 | Breast Cancer Res Treat1996，39，3： | 1 |
| 13 | The new tumor sup- pressor genes ING: genomic structure and status in cancer 显示文摘 | Ythier D Larrieu D Brambilla C | 2008 | Int J Cancer2008，123，7： | 1 |
| 14 | Primary chemotherapy in operable breast cancer:eight-year experience at the Milan Cancer Institute显示文摘 | Bonadonna G Valagussa P Brambilla C | 1998 | Clin Oncol1998，16，1： | 1 |
| 15 | Identification and quantification method of spiramycin and tylosin in feedingstuffs with HPLC-UV/DAD at 1 ppm level显示文摘 | Civitareale C Fiori M Ballerini A Brambilla G | | 0，，： | 1 |
| 16 | Toxicity of several important agricultural antibiotics to Artemia显示文摘 | Migilore L Civitareale C Brambilla G | 1997 | Water Research1997，31，7： | 1 |
| 17 | Pleiotropic function of ezrin in human metastatic melanomas显示文摘 | Federici C Brambilla D | 2009 | Int J Cancer2009，124，12： | 1 |
| 18 | Early detection of lung cancer:role of biomarkers显示文摘 | Brambilla C Fievet F Jeanmart M | 2003 | Eur Respir J Suppl2003，39，： | 1 |
| 19 | Functional serotonin in5-HTTLPR polymorphism is a risk factor for migraine with aura显示文摘 | Borroni B Brambilla C Liberini P | 2005 | J Headache Pain2005，6，4： | 1 |
| 20 | A simple role for BDNF in learning and memory显示文摘 | Cunha C Brambilla R Thomas KL | 2010 | Front Mol Neurosci2010，3，： | 1 |
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