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| 1 | Pathophysiology of chronic pancreatitis显示文摘Chronic pancreatitis(CP)is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory parenchyma.Despite the heterogeneity in pathogenesis and involved risk factors,processes such as necrosis/apoptosis,inflammation or duct obstruction are involved.This fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas,deformation of the large ducts and severe changes in the arrangement and composition of the islets.These conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine functions.The prevalence of the disease is largely dependent on culture and geography.The etiological risk-factors associated with CP are multiple and involve both genetic and environmental factors.Throughout this review the M-ANNHEIM classification system will be used,comprising a detailed description of risk factors such as:alcohol-consumption,nicotineconsumption,nutritional factors,hereditary factors,efferent duct factors,immunological factors and miscellaneous and rare metabolic factors.Increased knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools,which potentially will help clinicians to diagnose CP at an earlier stage.However,in view of the multi factorial disease and the complex clinical picture,it is not surprising that treatment of patients with CP is challenging and often unsuccessful. | Christina Brock Lecia Mφller Nielsen Dina Lelic Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 11 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | Modified water regime and salinity as a consequence of climate change: Prospects for wetl rods of Southern Australia 显示文摘 | NIELSEN D L BROCK M A | 2009 | Climatic Change2009，95，34： | 1 |
| 4 | Feasibility of a novel deformable image registration technique to facilitate elassifieation, targeting, and monitoring of tumor and normal tissue 显示文摘 | Brock K K Dawson L A Sharpe M B | 2006 | Int J Radiat Oneol Biol Phys2006，64，4： | 1 |
| 5 | Age-related cataract显示文摘 | Asbell PA Dualan I Mindel J Brocks D Ahmad M Epstein S etal | 2005 | Lancet2005，365，9459： | 1 |
| 6 | Comparative proteomic analysis of matched primary and metastatic melanoma cell lines显示文摘 | AL-GHOUL M BROCK T B LAUER-FIELDS J L | 2008 | J Proteome Res2008，7，9： | 1 |
| 7 | Toward dynamic and attribute based publication, discovery and selection for cloud computing 显示文摘 | GOSCINSKI A BROCK M | 2010 | Future Generation Computer Systems2010，26，7： | 1 |
| 8 | Cerebral edema following experimental subarachnoid hemorrhage 显示文摘 | Shigeno T Fritschka E Brock M | 1982 | Stroke1982，13，3： | 1 |
| 9 | How do depth, duration and frequency of flooding influence the establishment of wetland plant communities显示文摘 | Casanova M T Brock M A | 2000 | Plant Ecology2000，147，： | 1 |
| 10 | The small frontolateral approach for the micr- osurgical treatment of intracranial aneurysms 显示文摘 | Brock M Dietz H | 1978 | Neurochirurgia1978，21，： | 1 |
| 11 | Measurement and parameterization of albedo variations at Haut Glacier d'Arolla, Switzerland显示文摘 | Brock B W Willis I C Sharp M J | 2000 | 46(155) : 675-6882000，46，155： | 1 |
| 12 | Factors associated with intracranial hemorrhage in cases of cerebral arteriovenous malformation 显示文摘 | Mannesmann U Merisel J Brock M | 2000 | Neurosurgery2000，46，2： | 1 |
| 13 | Multiparametric ultrasound of the prostate:adding contrast enhanced ultrasound to real-time elastography to detect histopathologically confirmed cancer显示文摘 | Brock M Eggert T Palisaar RJ | 2013 | J Urol2013，189，1： | 1 |
| 14 | Surgical resection for hilar cholangiocarcinoma: experience improves resectability 显示文摘 | Cannon R M Brock G Buell J F | 2012 | HPB (Oxford)2012，14，2： | 1 |
| 15 | Spectroscopy of few- electron collective excitations in charge tunable arti显示文摘 | Brocke T Boot smann MT Tews M | 2003 | Phys Rev Lett2003，91，25： | 1 |
| 16 | Bubble nucleation in an explosive micro-bubble actuator显示文摘 | van den Brock D M Elwenspoek M | 2008 | J Micromech Micro- eng2008，18，6： | 1 |
| 17 | Chemicalprecipitation of heavy metals from acid mine drainage显示文摘 | Matthew M Matlock Brock S Howerton David A Atwood | 2002 | WaterResearch2002，36，9： | 1 |
| 18 | Characterisation of the laccase-encoding gene abr 2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus 显示文摘 | Sugareva V Hartl A Brock M | 2006 | Arch Microbiol2006，186，5： | 1 |
| 19 | Fine Motor Skills and Executive Function Both Contribute to Kindergarten Achievement 显示文摘 | Cameron C E Brock L L Murrah W M | 2012 | Child Develop- ment2012，83，4： | 1 |
| 20 | Inflammatory cytokines pul- monary hypertension显示文摘 | Groth A Vruqt B Brock M | 2014 | Respir Res2014，15，： | 1 |
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