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| 1 | Novel adaptive neural control of flexible air-breathing hypersonic vehicles based on sliding mode differentiator显示文摘A novel adaptive neural control strategy is exploited for the longitudinal dynamics of a generic flexible air-breathing hypersonic vehicle(FAHV).By utilizing functional decomposition method, the dynamics of FAHV is decomposed into the velocity subsystem and the altitude subsystem.For each subsystem, only one neural network is employed for the unknown function approximation.To further reduce the computational burden, minimal-learning parameter(MLP)technology is used to estimate the norm of ideal weight vectors rather than their elements.By introducing sliding mode differentiator(SMD) to estimate the newly defined variables, there is no need for the strict-feedback form and virtual controller.Hence the developed control law is considerably simpler than the ones derived from back-stepping scheme.Finally, simulation studies are made to illustrate the effectiveness of the proposed control approach in spite of the flexible effects, system uncertainties and varying disturbances. | Bu Xiangwei Wu Xiaoyan Ma Zhen Zhang Rui | 2015 | Chinese Journal of Aeronautics2015，28，4： | 11 |
| 2 | Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC显示文摘Epithelial–mesenchymal transition(EMT)is involved in both physiological and pathological processes.EMT plays an essential role in the invasion,migration and metastasis of tumours.Autophagy has been shown to regulate EMT in a variety of cancers but not in head and neck squamous cell carcinoma(HNSCC).Herein,we investigated whether autophagy also regulates EMT in HNSCC.Analyses of clinical data from three public databases revealed that higher expression of fibronectin-1(FN1)correlated with poorer prognosis and higher tumour pathological grade in HNSCC.Data from SCC-25 cells demonstrated that rapamycin and Earle’s balanced salt solution(EBSS)promoted autophagy,leading to increased FN1 degradation,while 3-methyladenine(3-MA),bafilomycin A1(Baf A1)and chloroquine(CQ)inhibited autophagy,leading to decreased FN1 degradation.On the other hand,autophagic flux was blocked in BECN1 mutant HNSCC Cal-27 cells,and rapamycin did not promote autophagy in Cal-27 cells;also in addition,FN1 degradation was inhibited.Further,we identified FN1 degradation through the lysosome-dependent degradation pathway using the proteasome inhibitor MG132.Data from immunoprecipitation assays also showed that p62/SQSTM1 participated as an autophagy adapter in the autophagy–lysosome pathway of FN1 degradation.Finally,data from immunoprecipitation assays demonstrated that the interaction between p62 and FN1 was abolished in p62 mutant MCF-7 and A2780 cell lines.These results indicate that autophagy significantly promotes the degradation of FN1.Collectively,our findings clearly suggest that FN1,as a marker of EMT,has adverse effects on HNSCC and elucidate the autophagy–lysosome degradation mechanism of FN1. | Xinchen Liu Lin Meng Xing Li Daowei Li Qilin Liu Yumeng Chen Xiangwei Li Wenhuan Bu Hongchen Sun | 2020 | International Journal of Oral Science2020，12，4： | 7 |
| 3 | EMMD-Prony approach for dynamic validation of simulation models显示文摘Model validation and updating is critical to model credibility growth. In order to assess model credibility quantitatively and locate model error precisely, a new dynamic validation method based on extremum field mean mode decomposition(EMMD) and the Prony method is proposed in this paper. Firstly, complex dynamic responses from models and real systems are processed into stationary components by EMMD. These components always have definite physical meanings which can be the evidence about rough model error location. Secondly, the Prony method is applied to identify the features of each EMMD component. Amplitude similarity, frequency similarity, damping similarity and phase similarity are defined to describe the similarity of dynamic responses.Then quantitative validation metrics are obtained based on the improved entropy weight and energy proportion. Precise model error location is realized based on the physical meanings of these features. The application of this method in aircraft controller design provides evidence about its feasibility and usability. | Yongxing Chen Xiaoyan Wu Xiangwei Bu Ruiyang Bai | 2015 | Journal of Systems Engineering and Electronics2015，26，1： | 2 |
| 4 | A benign preparation of sec-butanol via transesterification from sec-butyl acetate using the acidic imidazolium ionic liquids as catalysts 显示文摘 | WANG Hongxing WU Chengming BU Xiangwei | 2014 | Chemical Engineering Journal2014，，246： | 1 |
| 5 | Nonsingular di- rect neural control of air - breathing hypersonic vehicle via back - stepping显示文摘 | Bu Xiangwei Wu Xiaoyan Ma Zhen Zhang Rui | 2015 | Neurocomputing2015，153，： | 1 |
| 6 | 固体运载火箭的技术特点与研制规律分析显示文摘Solid-propellant and liquid-propellant launch vehices have their own characteristics,both playing an im-portant role in space transportation systems of space powers.This paper reviews and summarizes the development history of solid-propellant launch vehicles,and analyzes their technical characteristics including multiple stages,large payloads,complex separation,diverse operation modes,fast response,and mission adaptability as well as unique ad-vantages in launch activities.This paper analyzes and proposes four development laws for solid-propellant launch vehi-des,including improving comprehensive performance,infusing heritage with innovation,unitization and seriation,and optimizing power systems.Finally,this paper proposes the opportunities and challenges faced by solid-propellant launch vehicles based on market demands. | BU Xiangwei YANG Haoliang SHI Xiaoning WEI Kai YANG Yiqiang | 2020 | Aerospace China2020，21，1： | 0 |
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