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| 1 | Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras显示文摘Objective and background: Although p21 ras has been reported to be upregulated in hepatocellular carcinoma complicating chronic hepatitis C type I, p21 ras has a different role in advanced stages, as it has been found to be downregulated. The goal of this study was to investigate the status of p21 ras in early-stage/low-grade and late-stage/high-grade hepatocellular carcinoma and its possible link to apoptosis. Material and methods: Thirty-five cases each of chronic HCV hepatitis type 4 (group I) and cirrhosis with hepatocellular carcinoma (HCC) complicating chronic HCV hepatitis (groups II and III) were immunohistochemically evaluated using a p21 ras polyclonal antibody. The apoptotic index was determined in histologic sections using the terminal deoxynucleotidyl transferase-mediated d-UTP biotin nick end labeling (TUNEL) assay. Results: Significant differences (P=0.001) were detected in p21 ras protein expression between the three groups. A near 2-fold increase in p21 ras staining was observed in the cirrhotic cases compared to the hepatitis cases, and p21 ras expression was decreased in the HCC group. p21 ras expression correlated with stage (r=0.64, P=0.001) and grade (r=-0.65, P=0.001) in the HCC group and grade in the HCV group (r=0.44, P=0.008). Both p21 ras expression and TUNEL-LI were significantly lower in large HCCs compared to small HCCs (P=0.01 each). The TUNEL values were negatively correlated with stage in the HCC group (r=-0.85, P=0.001). The TUNEL values were also negatively correlated with grade in both the HCV and HCC groups (r=0.89, P=0.001 and r=-0.53, P=0.001, respectively). The p21 ras scores were significantly correlated with the TUNEL-LI values in the HCC group (r=0.63, P=0.001) and HCV group (r=0.88, P=0.001). Conclusions: p21 ras acts as an initiator in HCC complicating type 4 chronic HCV and is downregulated with HCC progression, which most likely promotes tumor cell survival because it facilitates the downregulation of apoptosis with tumor progression. | Nahed Baddour Ebtehal Farrag Ahmed Zeid Essam Bedewy Yousry Taher | 2013 | Chinese Journal of Cancer Research2013，25，3： | 6 |
| 2 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 3 | Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Statement for Health Professionals From the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association显示文摘 | Jane W. Newburger Masato Takahashi Michael A. Gerber Michael H. Gewitz Lloyd Y. Tani Jane C. Burns Stanford T. Shulman Ann F. Bolger Patricia Ferrieri Robert S. Baltimore Walter R. Wilson Larry M. Baddour Matthew E. Levison Thomas J. Pallasch Donald A. Fa | 2004 | Circulation2004，，17： | 2 |
| 4 | Management and Outcome of Permanent Pacemaker and Implantable Cardioverter-Defibrillator Infections显示文摘 | Muhammad R. Sohail Daniel Z. Uslan Akbar H. Khan Paul A. Friedman David L. Hayes Walter R. Wilson James M. Steckelberg Sarah Stoner Larry M. Baddour | 2007 | Journal of the American College of Cardiology2007，，18： | 2 |
| 5 | Long-term suppressive antimicrobial therapy for intravascular device-related infections显示文摘 | Baddour LM | 2001 | Am J Med Sci2001，322，： | 1 |
| 6 | Turbulent gravity-stratified shear flows显示文摘 | CHU V T BADDOUR R E | 1984 | J Fluid Mech1984，138，： | 1 |
| 7 | Nenvalvular cardiovascular device-related infections显示文摘 | Baddour LM Bettmann MA Bolger AF | 2003 | Circulation2003，108，16： | 1 |
| 8 | Infective endocarditis:diagnosis,antimicrobial therapy,and management of complications:a statement for health care professionals from the Committee Cardiovascular Disease in the Young,and the Councils on Clinical Cardiology,on Rheumatic Fever,Endocarditis,and Kawasaki Disease,Council on Stroke,and Cardiovascular Surgery and Anesthesia,American Heart Endorsed by the Infectious Diseases Society of America Association显示文摘 | Wilson WR Bayer AS | 2005 | Circulation2005，111，： | 1 |
| 9 | Impact of healthcareassociated acquisition on community-onset gram-negative bloodstream infection:apopulation-based study:healthcare-associated gram-negative BSI显示文摘 | A-Hasan MN Eckel-Passow JE Baddour LM | 2012 | Eur J Clin Microbiol Infect Dis2012，31，6： | 1 |
| 10 | Three-dimensional dynamics of a flexible marine riser undergoing large elastic deformations显示文摘 | RAMAN-NAIR W BADDOUR R E | 2003 | Multibody System Dynamics2003，10，4： | 1 |
| 11 | Infection ertdecarditis complicating mitral valve prolapse: epidemilogic, clincal, and microbiology as- pects显示文摘 | BADDOUR LM BISNO AL | 1986 | Rev Infect Dis1986，8，10： | 1 |
| 12 | Fungal endocarditis, 1995-2000 显示文摘 | Pierrotti LC Baddour LM | 2002 | Chest2002，122，1： | 1 |
| 13 | Infective endocardi- tis : diagnosis, antimicrobial therapy, and management of compli- cations:a statement for healthcare professionals from the Com- mittee on Rheumatic Fever, Endocarditis, and Kawasaki Dis- ease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association : endorsed by the Infectious Diseases Society of America显示文摘 | Baddour LM Wilson WR Bayer AS | 2005 | Circulation2005，111，23： | 1 |
| 14 | Infective endocarditis: diagnosis, antimicrobial therapy, and management o显示文摘 | Baddour LM Wilson WR Bayer AS | 2005 | Circulation2005，111，23： | 1 |
| 15 | Update on cardiovascular implantable electronic device infections and their management:a scien- tific statement from the American Heart Association 显示文摘 | Baddour LM Epstein AE Er/ckson CC | 2010 | Circulation2010，121，45： | 1 |
| 16 | Global and regional burden of infective endocarditis,1990-2010:a systematic review of the literature显示文摘 | Bin Abdulhak AA Baddour LM Erwin PJ | 2014 | Glob Heart2014，9，： | 1 |
| 17 | Deformation of monochromatic water wave trains propagating over a submerged obstacle in the presence of uniform currents显示文摘 | M. Hasanat Zaman Hiroyoshi Togashi R. Emile Baddour | 2008 | Ocean Engineering2008，，8： | 1 |
| 18 | Conditioned polyethylene as a permselective membrane 显示文摘 | Michaels A S Baddour R F Bixler H J | 1962 | Ind Eng Chem Process Des Dev1962，1，： | 1 |
| 19 | Enhancing Penicillin fermentations by increased oxygen solubility through the addition of n- hexadecane 显示文摘 | Ho C S Ju L K Baddour R F | 1990 | Biotechnol Bioeng1990，36，： | 1 |
| 20 | Randomized prospective controlled trial of recombinant Granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection显示文摘 | Baddour LM | 2002 | Curr Infect Dis Rep2002，4，5： | 1 |
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