维普期刊资源整合服务平台（V6.5）

65篇 您的检索式：作者名="Bader O"

选中清除导出查看参考文献查看引证文献引用追踪共4页首页上一页第1页下一页末页 /4 跳转

	题名	作者	年代	出处	被引量
1	IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers.	Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez	2013	World Journal of Gastroenterology2013，19，2：	8
2	Identification and characterization of four azoleresistanterg3 mutants of Candida albicans显示文摘	MARTEL CM PARKER JE BADER O	2010	Antimicrob Agents Chemother2010，54，11：	1
3	Intellectual property management in inter- firm R&D collaborations 显示文摘	GASSMANN O BADER M A	2006	Taiwan Academy of Manage-ment Journal2006，，6：	1
4	Improved photobiological H2 production in engineered green algal cells显示文摘	KRUSE O RUPPRECHT J BADER K P	2005	J Biol Chem2005，280，34：	1
5	Secretory cell actin-binding proteins : identification of a gelsolin- like protein in chromaffin cells显示文摘	Bader M F Trifar6 J M Langley O K	1986	J Cell Biol1986，102，2：	1
6	Improved clinical laboratory identification of human pathogenic yeasts by matrix-as- sisted laser desorption ionization time-of-flight mass spectrometry 显示文摘	Bader O Weig M Taveme-Ghadwal L	2011	Clin Mierobiol Infect2011，17，9：	1
7	Tissue engineering of vascular grafts:human cell seeding of decellularised porcine matrix显示文摘	Bader A Steinhoff G	2000	Eur J Vasc Endovasc Surg2000，19，4：	1
8	Intellectual property management in inter - firm R&D collaborations 显示文摘	GASSMANN O BADER M A	2006	Taiwan Academy of2006，2006，6：	1
9	X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15 显示文摘	Bader I Brandau O Achatz H Apfelstedt-Sylla E Hergers-berg M Lorenz B	2003	Invest Ophthalmol Vis Sci2003，44，4：	1
10	X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15 显示文摘	Bader I Brandau O Achatz H	2003	Invest Ophthalmol Vis Sci2003，44，4：	1
11	X-linked Retinitis Pigmentosa:RPGR Mutations in Most Families with Definite X Linkage and Clustering of Mutations in a Short Sequence Stretch of Exon ORFl5显示文摘	BRANDAU O ACHATZ H	2003	Invest Ophthalmol Vis Sci2003，44，4：	1
12	Interaction between Mas and the angiotensin AT1 receptor in the amygdala显示文摘	von Bohlen und Halbach O Walther T Bader M	2000	J Neurophysiol2000，83，4：	1
13	Two clinical isolates of Candida glabrata exhibiting reduced sen amphotericin B both harbor mutations in sltlvity to ERG2显示文摘	Hull C M Bader O Parker J E	2012	Antimicrob Agents Chemother2012，56，12：	1
14	cyp51A-Based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany显示文摘	Bader O Weig M Reichard U	2013	Antimicrob Agents Chemother2013，57，8：	1
15	Identification and characterization of four azole-resistant erg3 mutants of Candida albieans显示文摘	Martel C M Parker J E Bader O	2010	Antimicrob Agents Chemother2010，54，11：	1
16	X-linked retlnitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15 显示文摘	Bader I Brandau O Achatz H	2003	Invest Ophthalmol Vis Sci2003，44，：	1
17	A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B显示文摘	Martel C M Parker J E Bader O	2010	Antimicrob Agents Chemother2010，54，9：	1
18	Genetic targeting of the brain renin- angiotensin system in transgenic rats: impact on stress-induced renin release显示文摘	Baltatu O Campos LA Bader M	2004	Acta Physiol Scan2004，181，4：	1
19	Use of the R5 Volume 4/5 procedures to assess creep-fatigue crack growth in a 316 L (N) cracked plate at 650℃ 显示文摘	Bader A J O' Dormell M P Dean D W	2003	International Journal of Pressure Vessels and Piping2003，80，：	1
20	Tissue renin-angiotensin systems:new insights from experimental animal models in hypertension research显示文摘	Bader M Peters J Baltatu O	2001	Journal of molecular medicine2001，79，：	1

返回顶部每页显示：

共4页首页上一页第1页下一页末页 /4 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示