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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | An integrated system for planning, navigation and robotic assistance for skull base surgery显示文摘BACKGROUND: We developed an image-guided robot system to provide mechanical assistance for skull base drilling,which is performed to gain access for some neurosurgical interventions, such as tumour resection. The motivation for introduc-ing this robot was to improve safety by preventing the surgeon from accidentally damaging critical neurovascular structures dur- | Baird C Jallo G Hayes K Nakajima N Hata N Kazanzides P | 2008 | 中国神经肿瘤杂志2008，6，3： | 6 |
| 3 | The inhibitors of apoptosis (IAPs) and their emerging role in cancer显示文摘 | LaCasse E C Baird S Korneluk R G | 1998 | Oncogene1998，17，25： | 1 |
| 4 | Development and applications of the reciprocating plate显示文摘 | Lo P C Baird M H I Rama Rao N V | 1992 | Column Chem Eng Commun1992，116，： | 1 |
| 5 | Spectroscopic measurement and analysis of water andoil in transformer insulating paper显示文摘 | Patrick J Baird Henryk Herman Gary C Stevens | 2006 | IEEE Transactions on Dielectrics and Electrical Insulation2006，13，1： | 1 |
| 6 | Larval Development of the Rodent Botfly,Cuterebra tenebrosa,in Bushy Tailed Wood Rats and Its Rela-tionship to Pupal Diapause显示文摘 | BAIRD C R | 1975 | Can J Zool1975，53，12： | 1 |
| 7 | Acquired immunity to malaria显示文摘 | Doolan DL Dobano C Baird JK | 2009 | Clin Microbiol Rev2009，22，1： | 1 |
| 8 | Squamous cell carcinoma in situ arising in inflammatory cloacogenic polyps : report of two cases with PCR analysis for HPV DNA 显示文摘 | Jaworski R C Biankin S A Baird P J | 2001 | Pathology2001，33，： | 1 |
| 9 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 10 | The inbibitors of apoptosis (IAPs) and their emerging role in cancer 显示文摘 | Lacassc E C Baird S Korncluk R G | 1998 | Oncogene1998，17，： | 1 |
| 11 | Measuring early language development in preschool children with autism spectrum disorder using the MacArthur Communicative Development Inventory (Infant Form)显示文摘 | Charman T Drew A Baird C | 2003 | J Child Lang2003，30，1： | 1 |
| 12 | Zinc toxicity following massive coin ingestion显示文摘 | Bennett DR Baird C J Chan KM | 1997 | Am Forensic Med Pathol1997，18，： | 1 |
| 13 | Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CC14 poisoning显示文摘 | Kadiiska M B Gladen B C Baird D D | 2005 | Free Radic Biol Med2005，38，： | 1 |
| 14 | Minimally disruptive decompression and transforaminal lumbar interbody fusion显示文摘 | Ozgur B M Hughes S A Baird L C | 2006 | Spine J2006，6，1： | 1 |
| 15 | From social media to social customer relationship management 显示文摘 | Heller Baird C Parasnis G | 2011 | Strategy & Leadership2011，39，5： | 1 |
| 16 | Maintenance of 3T3-L1cells in culture media containing saturated fatty acids decreases insulin binding and insulin action显示文摘 | GRUNFELD C BAIRD K L KAHN C R | 1981 | Biochem Biophys Res Commun1981，103，1： | 1 |
| 17 | Importance of vegetative cover to cycles of Microtus populations 显示文摘 | Birney E C Grant W E Baird D D | 1976 | Ecology1976，57，： | 1 |
| 18 | Laboratory toxicity test and post-exposure feeding inhibition using the giant freshwater prawn Macrobrachium rosenbergii 显示文摘 | Satapornvanit K Baird D J Little D C | 2009 | Chemosphere2009，74，9： | 1 |
| 19 | From social media to social customer relationship management 显示文摘 | Baird C H Parasnis G(2011 ) | 2011 | Strategy & Leadership2011，3037，： | 1 |
| 20 | Selective ring opening of naphthenic molecules显示文摘 | McVicker G B Daage M Touvelle M S Hudson C W Klein D P Baird W C Cook B R Chen J G Hantzer S Vaughan D E W Ellis E S Feeley O C | | 0，，01： | 1 |
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