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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Discovery of novel sulfonated small molecules that inhibit vascular tube formation显示文摘 | Karthik Raman Rajesh Karuturi Vimal P. Swarup Umesh R. Desai Balagurunathan Kuberan | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，13： | 2 |
| 3 | Characterisation of heteroresistant sub- colonies for MBL,AmpC genes in Klebsiella pneumoniae and Acine- tobacter baumannii 显示文摘 | Shanthi J Balagurunathan R | 2014 | Indian journal of medical microbiology2014，32，2： | 1 |
| 4 | Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray显示文摘 | David L. Morse Yoga Balagurunathan Galen Hostetter Maria Trissal Narges K. Tafreshi Nancy Burke Mark Lloyd Steven Enkemann Domenico Coppola Victor J. Hruby Robert J. Gillies Haiyong Han | 2010 | Biochemical Pharmacology2010，，5： | 1 |
| 5 | Mechanisms of buffer therapy resistance显示文摘 | Kate M. Bailey Jonathan W. Wojtkowiak Heather H. Cornnell Maria C. Ribeiro Yoganand Balagurunathan Arig Ibrahim Hashim Robert J. Gillies | 2014 | Neoplasia2014，，4： | 1 |
| 6 | An Extremely Simple and Effective Colony PCR Procedure for Bacteria, Yeasts, and Microalgae显示文摘 | Heiko Packeiser Chanyuen Lim Balaji Balagurunathan Jinchuan Wu Hua Zhao | 2013 | Applied Biochemistry and Biotechnology2013，，2： | 1 |
| 7 | Characterisation of heteroresistant subcolonies for MBL,AmpC genes in Klebsiella pneumoniae and Acinetobacter baumannii显示文摘 | Shanthi J Balagurunathan R | 2014 | Indian J Med Microbiol2014，32，2： | 1 |
| 8 | Antibiotic pigment from desert soil actinonycetes biological activity, purification and chemical screening显示文摘 | Selvameenal L Radhakrishnan M Balagurunathan R | 2009 | Indian J Pharrn Sci2009，71，5： | 1 |
| 9 | Preliminary screening for antibacterial and antimycobacterial activity of actinomycetes from less explored ecosystems 显示文摘 | Radhakrishnan M Suganya S Balagurunathan R | 2010 | World J Microbiol Biotechnol2010，26，： | 1 |
| 10 | Antibiotic pigment from desert soil actinomycetes;biological activity,purification and chemical screening显示文摘 | Selvameenal L Radhakrishnan M Balagurunathan R | | 0，，05： | 1 |
| 11 | Preliminary screening for antibacterial and antimycobacterial activity of actinomycetes from less explored ecosystems显示文摘 | Manikkam Radhakrishnan S. Suganya Ramasamy Balagurunathan Vanaja Kumar | 2010 | World Journal of Microbiology and Biotechnology2010，，3： | 1 |
| 12 | Reconstruction and analysis of a genome-scale metabolic model for Scheffersomyces stipitis显示文摘 | Balagurunathan B Jonnalagadda S Tan L | 2012 | Microbial Cell Factories2012，11，： | 1 |
| 13 | A pilot study of radiologic measures of abdominal adiposity:weighty contributors to early pancreatic carcinogenesis worth evaluating?显示文摘Objective:Intra-abdominal fat is a risk factor for pancreatic cancer(PC),but little is known about its contribution to PC precursors known as intraductal papillary mucinous neoplasms(IPMNs).Our goal was to evaluate quantitative radiologic measures of abdominal/visceral obesity as possible diagnostic markers of IPMN severity/pathology.Methods:In a cohort of 34 surgically-resected,pathologically-confirmed IPMNs(17 benign;17 malignant) with preoperative abdominal computed tomography(CT) images,we calculated body mass index(BMI) and four radiologic measures of obesity:total abdominal fat(TAF) area,visceral fat area(VFA),subcutaneous fat area(SFA),and visceral to subcutaneous fat ratio(V/S).Measures were compared between groups using Wilcoxon two-sample exact tests and other metrics.Results:Mean BMI for individuals with malignant IPMNs(28.9 kg/m^2) was higher than mean BMI for those with benign IPMNs(25.8 kg/m^2)(P=0.045).Mean VFA was higher for patients with malignant IPMNs(199.3 cm^2) compared to benign IPMNs(120.4cm^2),P=0.092.V/S was significantly higher(P=0.013) for patients with malignant versus benign IPMNs(1.25 vs.0.69 cm^2),especially among females.The accuracy,sensitivity,specificity,and positive and negative predictive value of V/S in predicting malignant IPMN pathology were 74%,71%,76%,75%,and 72%,respectively.Conclusions:Preliminary findings suggest measures of visceral fat from routine medical images may help predict IPMN pathology,acting as potential noninvasive diagnostic adjuncts for management and targets for intervention that may be more biologically-relevant than BMI.Further investigation of gender-specific associations in larger,prospective IPMN cohorts is warranted to validate and expand upon these observations. | Jennifer B.Permuth Jung W.Choi Dung-Tsa Chen Kun Jiang Gina DeNicola Jian-Nong Li Domenico Coppola Barbara A.Centeno Anthony Magliocco Yoganand Balagurunathan Nipun Merchant Jose G.Trevino Daniel Jeong | 2017 | Cancer Biology & Medicine2017，14，1： | 1 |
| 14 | Genomic profiles and predictive biological networks in oxidant-induced atherogenesis显示文摘 | Johnson CD Balagurunathan Y Lu KP | 2003 | Physiol Genomics2003，13，3： | 1 |
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