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| 1 | Routine diagnosis of intestinal tuberculosis and Crohn's disease in Southern India显示文摘AIM:To investigate whether routinely measured clinical variables could aid in differentiating intestinal tuberculosis(ITB)from Crohn’s disease(CD).METHODS:ITB and CD patients were prospectively included at four South Indian medical centres from October 2009 to July 2012.Routine investigations included case history,physical examination,blood biochemistry,ileocolonoscopy and histopathological examination of biopsies.Patients were followed-up after 2 and 6 mo of treatment.The diagnosis of ITB or CD was re-evaluated after 2 mo of antituberculous chemotherapy or immune suppressive therapy respectively,based on improvement in signs,symptoms and laboratory variables.This study was considered to be an exploratory analysis.Clinical,endoscopic and histopathological features recorded at the time of inclusion were subject to univariate analyses.Disease variables with sufficient number of recordings and P<0.05 were entered into logistic regression models,adjusted for known confounders.Finally,we calculated the odds ratios with respective confidence intervals for variables associated with either ITB or CD.RESULTS:This study included 38 ITB and 37 CD patients.Overall,ITB patients had the lowest body mass index(19.6 vs 22.7,P=0.01)and more commonly reported weight loss(73%vs 38%,P<0.01),watery diarrhoea(64%vs 33%,P=0.01)and rural domicile(58%vs 35%,P<0.05).Endoscopy typically showed mucosal nodularity(17/31 vs 2/37,P<0.01)and histopathology more frequently showed granulomas(10/30vs 2/35,P<0.01).The CD patients more frequently reported malaise(87%vs 64%,P=0.03),nausea(84%vs 56%,P=0.01),pain in the right lower abdominal quadrant on examination(90%vs 54%,P<0.01)and urban domicile(65%vs 42%,P<0.05).In CD,endoscopy typically showed involvement of multiple intestinal segments(27/37 vs 9/31,P<0.01).Using logistic regression analysis we found weight loss and nodularity of the mucosa were independently associated with ITB,with adjusted odds ratios of 8.6(95%CI:2.1-35.6)and 18.9(95%CI:3.5-102.8)respectively.Right lower abdominal quadrant pain on examination and involvement of≥3 intestinal segments were independently associated with CD with adjusted odds ratios of 10.1(95%CI:2.0-51.3)and 5.9(95%CI:1.7-20.6),respectively.CONCLUSION:Weight loss and mucosal nodularity were associated with ITB.Abdominal pain and excessive intestinal involvement were associated with CD.ITB and CD were equally common. | Geir Larsson Thrivikrama Shenoy Ramalingom Ramasubramanian Leena Kondarappassery Balakumaran Milada Cvancarova Smstuen Gunnar Aksel Bjune Bjφrn Allan Moum | 2014 | World Journal of Gastroenterology2014，20，17： | 5 |
| 2 | In vivo transter of intracellular labels from locally implanted bone marrow stromal cells to resident tissue macrophages显示文摘 | Pawelezyk E Jordan EK Balakumaran A | 2009 | PLoS One2009，4，8： | 1 |
| 3 | Verapamilstereoisomers induce antiproliferative effects in vascular smoothmuscle cells via autophagy 显示文摘 | Salabei JK Balakumaran A Frey JC | 2012 | Toxicol Appl Pharmacol2012，262，3： | 1 |
| 4 | Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer显示文摘 | Hsu D S Balakumaran B S Acharya C R | 2007 | J Clin Oncol2007，25，28： | 1 |
| 5 | MYC Activity miti- gates response to Rapamycin in prostate cancer through 4EBPI- mediated inhibition of autophagy 显示文摘 | Balakumaran BS Porrello A Hsu DS et at | 2009 | Cancer Rcs2009，69，19： | 1 |
| 6 | Bone marrow microenvironment in myelomagenesis:its potential role in early diagnosis显示文摘 | Balakumaran A Robey PG Fedarko N | | 0，，04： | 1 |
| 7 | In vivo transfer of intracellular labels from locally implanted bone marrow stromal cells to resident tissue macrophages显示文摘 | Pawelczyk E Jordan E K Balakumaran A | 2009 | PLoS One2009，4，8： | 1 |
| 8 | Verapamil stereoisomers induce antiproliferative effects in vascular smooth muscle cells via autophagy 显示文摘 | Salabei JK Balakumaran A Frey JC | 2012 | Toxicol Appl Phar- macol2012，262，： | 1 |
| 9 | MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy显示文摘 | Balakumaran BS Porrello A Hsu DS | 2009 | Cancer Res2009，69，19： | 1 |
| 10 | Analysis of a large single-center experience with robot-assisted pyeloplasty显示文摘 | Tobis S Venigalla S Balakumaran K | | International Journal of Urology0，，： | 1 |
| 11 | Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis显示文摘 | Balakumaran A Robey PG Fedarko N | 2010 | Expert Rev Mol Diagn2010，10，： | 1 |
| 12 | Characteri- zing the developmental pathways TTF-I, NKX2-8, and PAX9 in lung cancer显示文摘 | Hsu DS Acharya CR Balakumaran BS | 2009 | Pro Natl Acad SCI USA2009，106，13： | 1 |
| 13 | Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis 显示文摘 | Balakumaran A Robey PG Fedarko N | | Expert Rev Mol Dian0，10，4： | 1 |
| 14 | The dilemma of diagnosing the cause of hypernatraemia:drinking habits vs diabetes insipidus显示文摘 | BALAKUMARAN A BICHET D G | 2004 | Nephrol Dial Transplant2004，19，12： | 1 |
| 15 | Drug enterocyte adducts:possible causal factor for diclofenac enteropathy in rats显示文摘 | Atchison CR West AB Balakumaran A | | 0，，： | 1 |
| 16 | Smoldering (asymptomatic) multiple myeloma: revisiting the clinical dilemma and looking into the future显示文摘 | Waxman AJ Kuehl M Balakumaran A | 2010 | Clin Lymphoma Myeloma Leuk2010，10，4： | 1 |
| 17 | In vivo transfer of intracellular labels from locally implanted bone marrow stromal cells to resident tissue macrophages显示文摘 | Pawelczyk E Jordan EK Balakumaran A | 2009 | PLoS One2009，4，8： | 1 |
| 18 | Analysis of a large single-center experience with robot-assisted pyeloplasty显示文摘 | Tobis S Venigalla S Balakumaran K | 2013 | Int J Urol2013，20，2： | 1 |
| 19 | Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis显示文摘 | Balakumaran A Robey PG Fedarko N | 2010 | Expert Rev Mol Diagn2010，10，4： | 1 |
| 20 | MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy显示文摘 | Balakumaran BS Porrello A Hsu DS | 2009 | Cancer Res2009，69，19： | 1 |
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