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| 1 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 2 | Transforming growth factor-betal(TGF-betal):a potential recovery signal in the post-ischemie kidney显示文摘 | Docherty N G Perez-Barriocanal F Balboa N E Lopez-Novoa J M | 2002 | Ren Fail2002，24，： | 1 |
| 3 | Mycobacterium tuberculosis impairs dendritic cell response by altering CDlb, DC-SIGN and MR profile显示文摘 | Balboa L Romero MM Yokobori N Schierloh P Geffner L Basile JI Musella RM Abbate E de la Barrera S Sasiain MC Alemdn M | 2010 | Immunol Cell Biol2010，88，7： | 1 |
| 4 | Weak antiferromagnetism in carboxylato copper(Ⅱ) complexes of bipyridines显示文摘 | Castineiras A Balboa S Bermejo E | 2002 | Z Anorg Allg Chem2002，628，： | 1 |
| 5 | Impaired dendritic cell differentiation of CD16-positive monocytes in tuberculosis: role of p38 MAPK显示文摘 | Balboa L Romero MM Laborde E | 2013 | Eur J Immunol2013，43，2： | 1 |
| 6 | Recent insights on the role of cholesterol in non- alcoholic fatty liver disease 显示文摘 | Arguello G Balboa E Arrese M | 2015 | Biochim Biophys Acta2015，1852，9： | 1 |
| 7 | Use of a comprehensive panel of biomarkers to predict response to a fluorouracil-oxalipla- tin regimen in patients with metastatic colorectal cancer 显示文摘 | Lamas MJ Duran G Balboa E | 2011 | Pharmacogenomics2011，12，3： | 1 |
| 8 | Effects of nefazodone on the developmentof experimentally induced tumors in stressed rodents显示文摘 | Freire-Garabal M Rey-Méndez M García-Vallejo L Balboa J Suárez J Rodrigo E | 2004 | Psycho-pharmacology(Berl)2004，176，： | 1 |
| 9 | Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease显示文摘 | Vázquez MC Balboa E Alvarez AR | 2012 | Oxid Med Cell Longev2012，2012，20： | 1 |
| 10 | Evolutionary analyses of entire genomes do not support the association of mtDNA mutations with Ras/MAPK pathway syndromes显示文摘 | Go'mez-CarbaUa A Cerezo M Balboa E | 2011 | PLoS ONE2011，6，18： | 1 |
| 11 | Use of a comprehensive panel of biomarkers to predict response to a fluorouracil - oxaliplatin regimen in patients with metastatic colorectal cancer 显示文摘 | Lamas M J Duran G Balboa E | 2011 | Pharmacogenomics2011，12，3： | 1 |
| 12 | Isoform - specific redistri- bution of protein kinase C in living cells显示文摘 | Godson C Masliah E Balboa MA | 2006 | Biochim Biophys Acta2006，21，： | 1 |
| 13 | Deficiency of Niemarm-Pick C1 protein protects against diet-induced gallstone formation in mice显示文摘 | Morales MG Amigo L Balboa E | 2010 | Liver Int2010，30，6： | 1 |
| 14 | Recent insights on the role ofcholesterol in non-alcoholic fatty liver disease显示文摘 | Argnello G Balboa E Arrese M | 2015 | Biochim Biophys Acta2015，1852，9： | 1 |
| 15 | Evolutionary analyses of entire genomes do not support the association of mtDNA mutations with Ras/MAPK pathway syndromes显示文摘 | Gómez-Carballa A Cerezo M Balboa E | 2011 | PLoS One2011，6，18： | 1 |
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