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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Respiratory syncytial vi-ms infection inflammatory and immune responses to clm'a cell secre- tory protein modulates lung显示文摘 | Wang SZ Rosenberger CL Bao YX | 2003 | J Immunol2003，171，2： | 1 |
| 3 | The expression and function of Notch path-way genes in the developing rat eye 显示文摘 | Bao TIL Cepko CL | 1997 | J Neurosci1997，17，4： | 1 |
| 4 | Implication of Stable Jet Length in Electrospinning for Collecting Well-Aligned Ultrafine PLLA Fibers显示文摘 | Zhou Q H Bao M Yuan H H cl al | 2013 | Polymer2013，54，25： | 1 |
| 5 | Evaluating high temperature modulus and strength of alumina tube in vacuum by a modified split ring method显示文摘 | LIU Z BAO YW HU CL | 2016 | Key Engineering Materials2016，680，： | 1 |
| 6 | Alzheimer's disease and oxidative stress显示文摘 | Bao YM Yu DH Wei CL | 2006 | Biomed England2006，23，5： | 1 |
| 7 | Clara cell secretory protein modulates lung inflanmatory and immune responses to respiratory syn- cytial virus infection显示文摘 | Wang SZ Rosenberger CL Bao YX | 2003 | J immunol2003，171，2： | 1 |
| 8 | Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncy: tial virus infection 显示文摘 | Wang SZ Rosenbergcr CL Bao YX | 2003 | J Immunol2003，171，2： | 1 |
| 9 | Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection显示文摘 | Wang SZ Rosenberger CL Bao YX | 2003 | J Immunol2003，171，10： | 1 |
| 10 | IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection显示文摘 | Wang SZ Bao YX Rosenberger CL | 2004 | J Immunol2004，173，6： | 1 |
| 11 | Clara cell secretory protein modulates lung inflanmatory and immune responses to respiratory syncytial virus infection显示文摘 | Wang SZ Rosenberger CL Bao YX | 2003 | J immunol2003，171，2： | 1 |
| 12 | Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection 显示文摘 | Wang SZ Rosenberge CL Bao YX | 2003 | J Immunol2003，171，2： | 1 |
| 13 | Clinical observation on 48 cases of peripheral facial paralysis by acupoint-pene- trating acupuncture显示文摘 | Deng X Bao CL Zhang YL | 2012 | J Acupunct Tuina Sci2012，24，3： | 1 |
| 14 | IL-12p40 and IL-18 modulate irflammatory ard immune responses to respiratory syncytial virus infection显示文摘 | Wang SZ Bao YX Rosenberger CL | 2004 | J Immunol2004，173，6： | 1 |
| 15 | Clinical observation on 48 cases of peripheral facial paralysis treated by acupoint-penetrating acupuncture显示文摘 | Deng X Bao CL Zhang YL | 2012 | J Acupunct Tuina Sci2012，24，3： | 1 |
| 16 | Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection显示文摘 | Wang SZ Rosenberger CL Bao YX | 2003 | J Immunol2003，171，2： | 1 |
| 17 | IL-12p40 and IL-18 modulate inflammatory and immure responses to respiratory syncytial virus infection显示文摘 | Wang SZ Bao YX Rosenberger CL | 2004 | J Immunol2004，173，6： | 1 |
| 18 | Folic acid-conjugated Silicamodified gold nanorods for X-ray/CT imaging-guided dualmode radiation and photo-thermal therapy显示文摘 | Huang P Bao L Zhang CL | | 0，，： | 1 |
| 19 | Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection显示文摘 | Wang SZ Rosenberger CL Bao YX | | 0，，02： | 1 |
| 20 | Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy 显示文摘 | Huang P Bao L Zhang CL | 2011 | Biomaterials2011，32，36： | 1 |
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