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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A placebo - controlled,double -blind ,randomized trial of an extract of Ginkgo biloba for dementis, North American Egb study group 显示文摘 | Le Bars PL Ketz MM Berman N | 1997 | JAMA1997，278，16： | 1 |
| 3 | ImmuKnow: a new parameter in immune monitoring of pediatric liver transplantation recipients 显示文摘 | Israeli M Klein T Sredni B Avitzur Y Mor E Bar Nathen N | 2008 | Liver Transpl2008，14，： | 1 |
| 4 | A placebo-controlled,double-blind,randomized trial of an extract of Ginkgo biloba for dementis显示文摘 | Le Bars PL Katz MM Berman N | 1997 | JAMA1997，278，： | 1 |
| 5 | Induction of graft-versus-leukemia to prevent after partially lymphocyte-depleted allogeneic bone marrow transplantation by pre-emptive donor leukocyte infusion 显示文摘 | Schaap N Schattenberg A Bar B | 2001 | Leukemia2001，15，： | 1 |
| 6 | Interstitial bracherapy in soft tissue sarcomas:the Rambam experience显示文摘 | Rosenblatt E Meushar N Bar D | 2003 | Isr Med Assoe J2003，5，8： | 1 |
| 7 | Identification of failure modes in GFRP using PDVF sensors:ANN approach显示文摘 | H N Bar M R Bhat | 2004 | Composite Structures2004，65，： | 1 |
| 8 | Protective effect of Bax ablation against cell loss in the retinal ganglion layer induced by optic nerve crush in transgenic mice显示文摘 | Goldenberg-Cohen N Dratviman-Storobinsky O Dadon Bar E1 S | 2011 | J Neuroophthalmol2011，31，： | 1 |
| 9 | Late stimulation of the sphenopalatine-ganglion in ischemic rats : improvement in N-acetyl-Aspartate levels and diffusion weighted imaging characteristics as seen by MR显示文摘 | BAR SHIR A SHEMESH N NOSSIN MANOR R | 2010 | J Magn Reson Imaging2010，31，6： | 1 |
| 10 | Deblurring of color images corruped by impulsive noise显示文摘 | BAR L BROOK A SOCHEN N | 2007 | IEEE TIP2007，16，4： | 1 |
| 11 | A placebo- controlled,dauble- blind, randomized trial of an extract of Ginkgo biloha for dementia显示文摘 | Bars P L Katz M M Berman N | 1997 | J Am Med Assoc1997，278，： | 1 |
| 12 | A placebo - controlled,double-blind,randomized trial of an extract of Ginkgo biloba for dementia显示文摘 | Le - Bars PL Katz MM Rerman N | 1997 | J Am Med Assoc1997，278，16： | 1 |
| 13 | A placebo-controlled,double-blind,randomized trial of an extract of Ginkgo biloba for dementis显示文摘 | Le Bars PL Katz MM Berman N | 1997 | JAMA1997，278，： | 1 |
| 14 | Docetaxel and high-dose epirubicin as neoadjuvant chemotherapy in locally advanced breast cancer显示文摘 | E. Espinosa S. Morales P. Borrega A. Casas C. Madro?al I. Machengs J. A. Illarramendi J. Lizón J. A. Moreno J. Belón J. Janáriz M. Puente T. Checa J. R. Mel M. González Barón | 2004 | Cancer Chemotherapy and Pharmacology2004，，6： | 1 |
| 15 | miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics 显示文摘 | Bar N Dikstein R | 2010 | PLoS One2010，5，10： | 1 |
| 16 | More efficient predictive con- trol 显示文摘 | IMSLAND L BAR N FOSS B A | 2005 | Automatica2005，41，8： | 1 |
| 17 | Usage of smart antenna for cancelling neighboring base-station interferences in wireless CDMA communicaions显示文摘 | YE W C BAR N ALEXANDER M H | 1997 | IEEE Signals Systems & Computers1997，1998，1： | 1 |
| 18 | Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival显示文摘 | Bar SG Kaplan CV Ilan N | 2006 | Histopathology2006，49，2： | 1 |
| 19 | Image deblurring in the presence of salt-and-pepper noise显示文摘 | Bar L Sochen N Kiryati N | 2005 | Lecture Notes in Computer Science2005，3459，： | 1 |
| 20 | Impact of immune escape mutations on HIV-1fitness in the context of the cognate transmitted/founder genome显示文摘 | Song H Pavlicek J W Cai F Bhattacharya T Li H Iyer S S Bar K J Decker J M Goonetilleke N Liu M K Berg A Hora B Drinker M S Eudailey J Pickeral J Moody M A Ferrari G McMichael A Perelson A S Shaw G M Hahn B H Haynes B F Gao F | 2012 | Retrovirology2012，9，： | 1 |
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