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| 1 | Recurrence in node-negative advanced gastric cancer:Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series显示文摘AIM To analyze the clinicopathological characteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up. METHODS We enrolled 41 patients treated with curative gastrectomy for p T2-4 a N0 gastric carcinoma between 1992 and 2010,who developed recurrence(Group 1). We retrospectively selected this group from the prospectively collected database of 4 centers belonging to the Italian Research Group for Gastric Cancer,and compared them with 437 p T2-4 a N0 patients without recurrence(Group 2). We analyzed lymphatic embolization,microvascular infiltration,perineural infiltration,and immunohistochemical determination of p53,Ki67,and HER2 in Group 1 and in a subgroup of Group 2(Group 2 bis) of 41 cases matched with Group 1 according to demographic and pathological characteristics. RESULTS T4 a stage and diffuse histotype were associated with recurrence in the group of p N0 patients. In-depth pathological analysis of two homogenous groups of p N0 patients,with and without recurrence during longterm follow-up(groups 1 and 2 bis),revealed two striking patterns: lymphatic embolization and perineural infiltration(two parameters that pathologists can easily report),and p53 and Ki67,represent significant factors for recurrence.CONCLUSION The reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up. | Gian Luca Baiocchi Sarah Molfino Carla Baronchelli Simone Giacopuzzi Daniele Marrelli Paolo Morgagni Maria Bencivenga Luca Saragoni Carla Vindigni Nazario Portolani Maristella Botticini Giovanni De Manzoni | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 2 | Agreement dynamics on small-world networks显示文摘 | Dall'Asta L Baronchelli A Barrat A | 2006 | Europhys Lett2006，73，6： | 1 |
| 3 | Non-equilibrium dynamics of language games on complex networks显示文摘 | Dall'Asta L Baronchelli A Barrat A | 2006 | Phys Rev E2006，74，03： | 1 |
| 4 | Modeling human dynamics of face-to-face interaction networks显示文摘 | Starnini M Baronchelli A Pastor-Satorras R | 2013 | Physical Review Letters2013，110，16： | 1 |
| 5 | Chromosome territories, X Y translocation and premature ovarian failure: is there a relationship显示文摘 | Lissoni S Baronchelli S Villa N | 2009 | Mol Cytogenet2009，2，： | 1 |
| 6 | Cytogenetics of prema- ture ovarian failure: an investigation on 269 affected women显示文摘 | Baronchelli S Conconi D Panzeri E | 2011 | J Biomed Biotechnol2011，2011，37： | 1 |
| 7 | Microscopic activity patterns in the naming game显示文摘 | BARONCHELLI A | 2006 | J Phys A:Math Gen2006，39，14： | 1 |
| 8 | Nonequilibrium dynamics of language games on complex networks显示文摘 | BARONCHELLI A | 2006 | Phys Rev E2006，74，03： | 1 |
| 9 | Sharp transition towards shared vocabularies in multi-agent systems显示文摘 | Baronchelli A Felici M Loreto V | | 0，，： | 1 |
| 10 | Topology-induced coarsening in language games显示文摘 | DALL'ASTA L BARRAT A | 2006 | Phys Rev E2006，73，01： | 1 |
| 11 | Topology-induced coarsening in language games显示文摘 | Baronchelli A Dall'Asta L Barrat A | 2006 | Phys Rev E2006，73，01： | 1 |
| 12 | Sharp transition towards shared vocabularies in multi-agent systems显示文摘 | Baronchelli A Felici M Caglioti E | 2006 | Journal of Statistical Mechanics2006，，06： | 1 |
| 13 | Agreement dynamics on small-world networks显示文摘 | BARONCHELLI A BARRAT A | 2006 | Europhys Lett2006，73，6： | 1 |
| 14 | Voter mod- els on weighted networks显示文摘 | Baronchelli A Castellano C Pastor-Satorras R | 2011 | Physical Review E2011，83，6： | 1 |
| 15 | Sharp transition towards shared vocabularies in multi-agent systems显示文摘 | FELICI M LORETO V | 2006 | J Stat Mech2006，6，06： | 1 |
| 16 | Nonequilibrium dynamics of language games on complex networks显示文摘 | Dall'Asta L Baronchelli A Barrat A | 2006 | Phys Rev E2006，74，03： | 1 |
| 17 | Agreement dynamics on small-world networks显示文摘 | Dall'Asta L Baronchelli A Barrat A | 2006 | Europhys Lett2006，73，： | 1 |
| 18 | Connect and win:The role of social networks in political elections 显示文摘 | HALU A ZHAO Kun BARONCHELLI A | 2013 | EPL2013，102，1： | 1 |
| 19 | Sharp transition towards shared vocabularies in multi-agent systems显示文摘 | Baronchelli A Felici M Loreto V | 2006 | Journal of Statistical Mechanics: Theory and Experim2006，2006，6： | 1 |
| 20 | Topology induced coarsening in language games显示文摘 | Baronchelli A Dall'Asta L Barrat A | 2006 | Physical Review E2006，730，： | 1 |
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