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| 1 | 定量药理学:一个促进药物开发及转换型研究严谨思考的多学科领域显示文摘尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其交互作用时,自然便产生对临床药理学的协同作用。创新性和可塑性训练计划和策略均是将来临床研究工作中必不可少的要素。掌握定量药理学领域的知识成为对药理科学家的要求,具有定量药理学背景的人员可望获得更高的薪水。目前定量药理学相关培训计划,教学资料,及学术权威均比较贫乏,学生们可以从企业化、调控性的背景的教师等多种机构的教职员那获得指导,此外也可以通过在线课程,可视化教学进修课程,与他们的导师保持联系。对课程和学位的管理可以采取灵活的态度,这样可在短期内培养更多的定量药理学工作者。 | Jeffrey S Barrett Michael J Fossler K.David Cadieu Marc R Gastonguay 沈杰 谢海棠 孙瑞元 | 2008 | 中国临床药理学与治疗学2008，13，5： | 10 |
| 2 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 3 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 4 | Satellite identification of rain days over the upper Nile river basin using an optimum infrared rain/no-rain threshold temperature model显示文摘 | Todd M E C Barrett M J Beaumont | 1995 | J Appl Meteor1995，34，： | 2 |
| 5 | An electrophoretic ink for all-printed reflective electronic displays显示文摘 | Barrett Comiskey Albert J D Hidekazu Yoshizawa | 1998 | Nature1998，394，： | 2 |
| 6 | Two feet- two approaches: a component - based model of ecological footprinting 显示文摘 | Simmons C Lewis K Barrett J | 2000 | Ecological Economics2000，32，3： | 1 |
| 7 | Aparsimonious model for simulating floe in a karst aquifer显示文摘 | Michael E Barrett Randall J | 1997 | Journal of Hydrology1997，196，： | 1 |
| 8 | An Electrophoretic Ink for All-printed Reflective Electronic Displays显示文摘 | Barrett C Albert J D Yoshizawa H | 1998 | Nature1998，394，16： | 1 |
| 9 | Pregnancy outcomes in patients after radical trachelectomy 显示文摘 | Bernardini M Barrett J Seaward G | 2003 | Am J Obstet Gynecol2003，189，5： | 1 |
| 10 | Sequence comparisons using multiple sequences detect three times as many remote homo-logues as pairwise methods显示文摘 | Karplus K Barrett C | 1998 | J Mol Biol1998，284，4： | 1 |
| 11 | 显示文摘 | Stubington J F Barrett D | 1995 | Fuel Processing Technology1995，41，2： | 1 |
| 12 | Modulating chemokines:more lessons from viruses显示文摘 | LALANI A S BARRETT J W MCFADDEN G | 2000 | Immunol Today2000，21，2： | 1 |
| 13 | Minimum adjustment analog convergence system for curved faceplate projection tubes显示文摘 | Barrett G J | 1995 | Consumer Electronics IEEE Transactions on1995，41，3： | 1 |
| 14 | Extending ventilator circuit change interval beyond 2 days reduces the likelihood of ventilator-associated pneumonia显示文摘 | Fink J B Krause SA Barrett L | 1998 | Chest1998，113，2： | 1 |
| 15 | Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression显示文摘 | Dupont J Dunn S E Barrett J C | 2003 | Recent Prog Horm Res2003，58，： | 1 |
| 16 | Memory At- tack on Device-Independent Quantum Cryp- tography显示文摘 | BARRETT J COLBECK R KENT A | 2013 | Physical Review Letters2013，110，01： | 1 |
| 17 | Angiotensin lorverting enzyme insertion/aesetion polymorphism and cardio - vascular disease显示文摘 | CATrO A CARTER A M BARRETT J H | 1996 | Stroke1996，27，3： | 1 |
| 18 | Microwave ovenbased wet digestion technique显示文摘 | Petter Barrett Leon J Davidowskl Jr | 1978 | Anal Chem1978，50，7： | 1 |
| 19 | Rates and outcomes of primary and revision total hip replacement in the united states medicare population 显示文摘 | MAHOMED N N BARRETT J A KATZ J N | 2003 | J Bone Joint Surg Am2003，85，1： | 1 |
| 20 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates 显示文摘 | Roman-Leshkov Y Barrett C J Liu Z Y Dumesic J A | 2007 | Nature2007，447，： | 1 |
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