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| 1 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 2 | Evaluation of iodine content of certain vegetables 显示文摘 | BARAKAT M Z BASSIOUNI M EL-WAKIL M | 1972 | Bull Acad Pol Sci Ser Sci Biol1972，8，： | 1 |
| 3 | Silent otitis media clinical applications显示文摘 | Paparella MM Goycoolea M Bassiouni M | 1986 | Laryngoscope1986，96，： | 1 |
| 4 | Electron microscopy study of peripheral nerves in the uvulae of snorers and obstructive sleep apnoea patients显示文摘 | BASSIOUNY A NASR S MASHALY M | 2009 | J Laryngol Otol2009，123，： | 1 |
| 5 | Predictive schemes for handoff piioritization in cellular networks based on mobile positioning 显示文摘 | CHIU M H BASSIOUNI M | 2000 | IEEE Journal on Selected Areas in Communications2000，18，3： | 1 |
| 6 | Flow distribution and pressure drop in plate heat exchangers I-U type arrangement显示文摘 | Bassiouny M K Martin H | 1984 | Chemical Engineering Science1984，39，4： | 1 |
| 7 | Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers:evidence for a causal role in muscle fiber loss显示文摘 | Herbst A Pak JW McKenzie D Bua E Bassiouni M Aiken JM | | 0，，： | 1 |
| 8 | An improved task assignment scheme for Ha- doop running in the clouds 显示文摘 | Dai Wei Bassiouni M | 2013 | Journal of Cloud Computing Ad- vances Systems & Applications2013，2，1： | 1 |
| 9 | Effect of BQ-123 and tissue plasminogen activator on vasospasm after subarachnoid hemorrhage in monkey显示文摘 | Bassiouny M Mac Donal RL | 1996 | Stroke1996，27，3： | 1 |
| 10 | Biocomm- across-layer medium access con- trol (MAC) and routing protocol co-design for biomedical sensor networks显示文摘 | Bag A Bassiouni M A | 2009 | International Journal of Parallel Emergent and Dis- tributed Systems2009，24，： | 1 |
| 11 | Use of dabigatran for periprocedural anticoagulation in patients undergoing catheter ablation for atrial fibrillation 显示文摘 | Bassiouny M Saliba W Rickard J | 2013 | Cire Arrhythm Eleetrophysiol2013，6，3： | 1 |
| 12 | Tex- ture description using fractal and energy features 显示文摘 | KASPARIS T TZANNES N S BASSIOUNI M | 1995 | Com- puters & Electrical Engineering1995，21，1： | 1 |
| 13 | Risk factors and outcomes for primary, revision, and modified Lothrop (Draf III) frontal sinus surgery显示文摘 | Naidoo Y Bassiouni A Keen M | 2013 | Int Forum Allergy Rhino12013，3，5： | 1 |
| 14 | Modeling of heat transfer for flow across tube banks显示文摘 | Wilson A S Bassiouny M K | | 0，，01： | 1 |
| 15 | Two-temperature generalized thermo-piezoelastocity for one dimen- sional problems-state space approach 显示文摘 | YOUSSEF H M BASSIOUNY E | 2008 | Computa- tional Methods in Science and Technology2008，14，1： | 1 |
| 16 | Risk factors and outcomes for primary, revision, and modified Lothrop ( Draf III) frontal sinus surgery 显示文摘 | Naidoo Y Bassiouni A Keen M | 2013 | Int Forum Allergy Rhinol2013，3，5： | 1 |
| 17 | Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study显示文摘 | Bitagi MA Baset AA Bassiouny M | 2009 | Aeta Paediatr2009，19，1： | 1 |
| 18 | Intramedullary spinal cord metastasis from colonic carcinoma presenting as Brown-S6quard syndrome : a case report显示文摘 | Kaballo MA Brennan DD El Bassiouni M | 2011 | J Med Case Rep2011，5，： | 1 |
| 19 | Design and implementation of extended Boolean and comparison operators for time-oriented query languages显示文摘 | Mukherjee A Llewellyn M | 1994 | The Computer Journal1994，37，7： | 1 |
| 20 | Time-based operators for relational algebra query languages显示文摘 | Llewellyn M Mukherjee A | 1993 | Journal of Computer Languages1993，19，4： | 1 |
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