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| 1 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | Thermodynamic constraints for biochemical networks 显示文摘 | Beard D A Babson E Curtis E | 2004 | J Theor Biol2004，228，3： | 1 |
| 3 | Structure and mechanism of DNA polymerase Beta显示文摘 | BEARD W A WILSON S H | 2006 | Chem Rev2006，106，2： | 1 |
| 4 | The time of death after trauma显示文摘 | Wyatt J Beard D Gray A | 1995 | BMJ1995，310，： | 1 |
| 5 | Comparison of Fixed Film Reactors with a Modeled Sludge Blanket Reactor显示文摘 | Bachmann A Beard V L McCarty P L | 1983 | Fixed Film Biological Processes for Wastewater Treatment1983，，： | 1 |
| 6 | High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase显示文摘 | Hou E W Prasad R Beard W A | 2004 | Protein Exp Purif2004，34，1： | 1 |
| 7 | The effect of hyperoxia on cerebral blood flow: a study in healthy volunteers using magnetic resonance phase-contrast angiography显示文摘 | Watson N A Beards S C Altaf N Kassner A Jackson A | 2000 | Eur J Anaesthesiol2000，17，： | 1 |
| 8 | Nitric oxide regula- tion of gonadotrophin seeretion in prepubertal heifers显示文摘 | Honaramooz A Cook S J Beard A P et ol | 1999 | J Neu- roendoerinol1999，11，9： | 1 |
| 9 | 1 Physical ac-tivity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus显示文摘 | Russo-NeustadtA A Beard R C HuangYM eta | 2000 | Neuro science2000，101，2： | 1 |
| 10 | Pneumocystis colonisation is common among hospitalised HIV infected patients with nonpneumocystis pneumonia显示文摘 | Davis J L Welsh D A Beard C B | 2008 | Thorax2008，63，4： | 1 |
| 11 | A new under- standing of raindrop shape显示文摘 | Beard K V Bringi V N Thurai M A | 2010 | Atmos Res2010，97，： | 1 |
| 12 | Comparison of fixed film reactors with a modified sludge blanket reactor显示文摘 | Bachmann A Beard V L Mc Carty P L | 1983 | Pollut Technol Rev1983，10，： | 1 |
| 13 | Screen for novel cry genes by hybridization显示文摘 | Beard C E Ranasinghe C A Khurst R J | 2001 | Lett Appl Microbiol2001，33，： | 1 |
| 14 | PbTe colloidal nanocrystals: Synthesis, characterization, and multiple exciton generation显示文摘 | Murphy J E Beard M C Norman A G | 2006 | Journal of the American Chemical Society2006，128，10： | 1 |
| 15 | The influence of tunnel geometry and ventilation on the heat release rate of fire 显示文摘 | Carvel R O Beard A N Jowitt P W | 2004 | Fire Technology2004，40，1： | 1 |
| 16 | A nurse -coordinated educational initiative addressing primary care professionals' attitudes to and problem - solving in depression in older people - A pilot study 显示文摘 | Livingston G Yard P Beard A | 2000 | International Journal of Geriatric Psychiatry2000，15，： | 1 |
| 17 | A multidisciplinary field hospital as a substitute for medical hospital care in the aftermath of an earthquake: the experience of the Israeli Defense Forces Field Hospital in Duzce ,Turkey, 1999 显示文摘 | Bar Dayan Y Leiba A Beard P | 2005 | Prehosp Disaster Med2005，20，2： | 1 |
| 18 | Incidence and natural history of primary systemic amyloidosis in Olmstead County, Minesota, 1950 through 1989 显示文摘 | Kyle RA Linos A Beard CM | 1992 | Blood1992，79，7： | 1 |
| 19 | Ovarian function in ewes at the onset of the breeding season 显示文摘 | Artlewski P M Beard A P Rawling N C | 1999 | Anim-Reprod-Sci1999，57，2： | 1 |
| 20 | Characterization of Mg2+ inhibition of mitochondrial Ca2+ uptake by a mechanistic model of mitochondrial Ca2+ uniporter显示文摘 | Ranjan K Pradhan Qi Feng Beard D A | | 0，，09： | 1 |
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