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| 1 | Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras显示文摘Objective and background: Although p21 ras has been reported to be upregulated in hepatocellular carcinoma complicating chronic hepatitis C type I, p21 ras has a different role in advanced stages, as it has been found to be downregulated. The goal of this study was to investigate the status of p21 ras in early-stage/low-grade and late-stage/high-grade hepatocellular carcinoma and its possible link to apoptosis. Material and methods: Thirty-five cases each of chronic HCV hepatitis type 4 (group I) and cirrhosis with hepatocellular carcinoma (HCC) complicating chronic HCV hepatitis (groups II and III) were immunohistochemically evaluated using a p21 ras polyclonal antibody. The apoptotic index was determined in histologic sections using the terminal deoxynucleotidyl transferase-mediated d-UTP biotin nick end labeling (TUNEL) assay. Results: Significant differences (P=0.001) were detected in p21 ras protein expression between the three groups. A near 2-fold increase in p21 ras staining was observed in the cirrhotic cases compared to the hepatitis cases, and p21 ras expression was decreased in the HCC group. p21 ras expression correlated with stage (r=0.64, P=0.001) and grade (r=-0.65, P=0.001) in the HCC group and grade in the HCV group (r=0.44, P=0.008). Both p21 ras expression and TUNEL-LI were significantly lower in large HCCs compared to small HCCs (P=0.01 each). The TUNEL values were negatively correlated with stage in the HCC group (r=-0.85, P=0.001). The TUNEL values were also negatively correlated with grade in both the HCV and HCC groups (r=0.89, P=0.001 and r=-0.53, P=0.001, respectively). The p21 ras scores were significantly correlated with the TUNEL-LI values in the HCC group (r=0.63, P=0.001) and HCV group (r=0.88, P=0.001). Conclusions: p21 ras acts as an initiator in HCC complicating type 4 chronic HCV and is downregulated with HCC progression, which most likely promotes tumor cell survival because it facilitates the downregulation of apoptosis with tumor progression. | Nahed Baddour Ebtehal Farrag Ahmed Zeid Essam Bedewy Yousry Taher | 2013 | Chinese Journal of Cancer Research2013，25，3： | 6 |
| 2 | behicle crash modelling using recurrent neural networks显示文摘 | OMAR T ESKANDARIAN A BEDEWI N | 1998 | Mathematical and Computer Modelling1998，28，9： | 1 |
| 3 | Crashworthiness design optimization using successive response surface approximations显示文摘 | Kurtaran H Eskandarian A Marzougui D Bedewi N E | 2002 | Computational Mechanics2002，29，： | 1 |
| 4 | Impact finite-element analysis of slip-base sign support mechanism 显示文摘 | ESKANDARIAN A MARZOUGUI D BEDEWI N E | 2000 | Journal of Transportation Engineering2000，126，2： | 1 |
| 5 | Vehicle crash modeling using recurrent neural networks显示文摘 | OMAR T ESKANDARIAN A BEDEWI N | 1998 | Mathematical and Computer Modeling1998，28，9： | 1 |
| 6 | CD163 and c - met expression in the lymph node and the correlations be- tween elevated levels of serum free light chain and the dif- ferent clinicopathological parameters of advanced classical Hodgkin 's lymphoma显示文摘 | Bedewy M E1 - Maghraby S Bedewy A | 2013 | Blood Res2013，48，2： | 1 |
| 7 | Role of tissue liver X-receptors level in skin diseases显示文摘 | Bedewi EI Ahmed Nada E | 2013 | Int J Pept Res Ther2013，19，4： | 1 |
| 8 | Do SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in Egyptian chronic myeloid leukemia patients receiving imatinib therapy? 显示文摘 | Bedewy AM EI-Maghraby SM | 2013 | Hematology2013，18，4： | 1 |
| 9 | Assessing DcR3 expression in relation to survivin and other prognostic factors in B cell non-Hodgkin's lymphoma 显示文摘 | Bedewy AML Elgammal MMA Bedewy MML | 2013 | Ann Hematol2013，92，10： | 1 |
| 10 | Hair removal with intense pulsed light 显示文摘 | Bedewi AF | 2004 | Lasers Med Sci2004，19，1： | 1 |
| 11 | CD163 and c-met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin 's lymphoma显示文摘 | Bedewy M E1-Maghraby S Bedewy A | 2013 | Blood Res2013，48，2： | 1 |
| 12 | Vehicle crash modelling using recurrent neural networks显示文摘 | Omar T Eskandarian A Bedewi N | 1998 | Math Comput Model1998，28，9： | 1 |
| 13 | Association of cyclin D1 A870G polymorphism with two malignancies: acute lymphoblastic leukemia and breast cancer 显示文摘 | Bedewy AM Mostafa MH Saad AA | 2013 | J BUON2013，18，1： | 1 |
| 14 | Collective mechanism for the evolution and self-termination of vertically aligned carbon nanotube growth显示文摘 | Bedewy M Meshot E R Guo H | 2009 | The Journal of Physical Chemistry C2009，113，20： | 1 |
| 15 | Hair removal with intense pulsed light 显示文摘 | EL BEDEWI AF | 2004 | Lasers Med Sci2004，19，1： | 1 |
| 16 | CD163 and c - Met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin's lymphoma 显示文摘 | Bedewy M E1 - Maghraby S Bedewy A | 2013 | Blood Res2013，48，2： | 1 |
| 17 | Dynamics modeling of robotic manipulators using an artificial neural network显示文摘 | ESKANDARIAN A BEDEWI N E KRAMER B M | 1994 | J of Robotic Systems1994，11，1： | 1 |
| 18 | Hair removal with intense pulsed light 显示文摘 | E1 Bedewi AF | 2004 | Lasers Med Sei2004，19，1： | 1 |
| 19 | Vehicle crash modelling using recurrent neural networks 显示文摘 | OMAR T ESKANDARIAN A BEDEWI N | 1998 | Mathematical and computer Modelling1998，28，9： | 1 |
| 20 | Development of a detailed vehicle finite element model part Ⅰ:Methodology显示文摘 | Zaouk A Marzougui D Bedewi N | | 0，，01： | 1 |
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