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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | ICOS is an inducible T-cell costimulator structurally and functionally related to CD28 显示文摘 | Hutloff A Dittrich AU Beier KC | 1999 | Nature1999，397，6716： | 1 |
| 3 | p38 MAPK signaling during routine preimplantation development 显示文摘 | Natale D R Paliga A J Beier F | 2004 | Dev Biol2004，268，1： | 1 |
| 4 | Borehole thermal resistance from line-source model of in-situ tests显示文摘 | Beier R A Smith M D | 2002 | ASHRAE Transactions2002，108，2： | 1 |
| 5 | Minimum duration of in-situ tests on vertical boreholes显示文摘 | Beier R A Smith M D | 2003 | ASHRAE Transactions2003，109，2： | 1 |
| 6 | Transient heat transfer in a U - tubeborehole heat exchanger 显示文摘 | BEIER R A | 2014 | Applied Thermal Engi-neering2014，62，： | 1 |
| 7 | Generation of a recombinant oncolytic Newcastle disease virus and expression of a full IgG antibody from two transgenes显示文摘 | Puhler F Willuda J Puhlmann J Mumberg D Romer-Oberdorfer A Beier R | 2008 | Gene Ther2008，15，5： | 1 |
| 8 | ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28显示文摘 | Hutloff A Dittrich A M Beier K C Eljaschewitsch B Kraft R Anagnostopoulos I | 1999 | Nature1999，397，： | 1 |
| 9 | Induction, binding specificity and function of human ICOS显示文摘 | Beier K C Hutloff A Dittrich A M Heuck C Raucb A Buchner K | 2000 | Eur J Immunol2000，30，： | 1 |
| 10 | ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28显示文摘 | Hutloff A Dittrich A M Beier K C | 1999 | Nature1999，397，： | 1 |
| 11 | Insulin and insulin-like growth factor-I promote rabbit blastocyst development and prevent apoptosis显示文摘 | Herrler A Krusche CA Beier HM | 1998 | Biol Reprod1998，59，6： | 1 |
| 12 | ICOS is an inducible T-cell eos- timulator structurally and functionally related to CD28 显示文摘 | Hutloff A Dittrich K C Beier Bet a/ | 1999 | Nature1999，，： | 1 |
| 13 | Safety and efficacy of dual ther- apy with GSK233705 and salmeterol versus monotherapy with salmet- erol ,tiotropium, or placebo in a crossover pilot study in partially re- versible COPD patients显示文摘 | Beier J Van Noord J Deans A | 2012 | Int J Chmn Obstruct Pulmon Dis2012，7，： | 1 |
| 14 | Pressure-transient model for a vertically fractured well in a fractal reservoir显示文摘 | | 1994 | SPEFE1994，，6： | 1 |
| 15 | Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions 显示文摘 | Woods A Wang G Beier F | 2007 | J Cell Physi- ol2007，1，： | 1 |
| 16 | ICOS is an inducible T-cel co-stimulator structural y and functional y related to CD28显示文摘 | Hutloff A Dittrich AM Beier KC | | 0，，6716： | 1 |
| 17 | Mini-subvastus approachfor total knee replacement 显示文摘 | Haider A Beier A Neumann W | 2009 | Oper Orthop Traumatol2009，21，1： | 1 |
| 18 | Detection of Halofuginone Residues in Chicken Liver Tissue by HPLC and Monoclonal-Based Lmmunoassay显示文摘 | Beier R C Dutko T J Buckley S A | 1998 | J Aric Food Chem1998，46，： | 1 |
| 19 | Vagrant and the Social Order in Elizabethan England 显示文摘 | BEIER A L | 1974 | Past and Present1974，，64： | 1 |
| 20 | ICOS is an inducible T-cell co-stimulator structurally and functionally reated to CD28显示文摘 | Hutloff A Dittrich A M Beier K C | 1999 | Nature1999，397，6716： | 1 |
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