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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Requirement of the auxin polar transport system in early stages of Arabidopsis floral bud formation显示文摘 | OKADA K UEADA J KOMAKI M K BELL C J SHIMURA Y | 1991 | Plant Cell1991，3，7： | 1 |
| 3 | Visual Interactive Simulation-Histroy,Recent Developments and Major Issues显示文摘 | Robert M O'Keefe | 1987 | Simulation1987，49，3： | 1 |
| 4 | Peanut leaf photosynthetic activity in cool field environments显示文摘 | Bell M J Gillespie T J Roy R C | 1994 | Crop Science1994，34，4： | 1 |
| 5 | Weight gain and its predictors in Chinese adults 显示文摘 | BELL A C GE K POPKIN B M | 2001 | Int J Obsity2001，25，： | 1 |
| 6 | Rep-PCR-mediated genomic fingerprinting:a rapid and effective method to identify Clavibacter michiganensis显示文摘 | Louws F J Bell J Medina-Mora C M | 1998 | Phytopathology1998，88，： | 1 |
| 7 | Hypoxia Imaging in Gliomas With 18F-Fluoromisonidazole PET: Toward Clinical Translation 显示文摘 | Bell C Dowson N Fay M | 2015 | Semin Nucl Med2015，45，2： | 1 |
| 8 | Hepatic de novo lipogenesis in stable low-birth-weight infants during exclusive breast milk feedings and during parenteral nutrition 显示文摘 | Garg M Bassilian S Bell C | 2005 | JPEN J Parenter Enteral Mutr2005，29，2： | 1 |
| 9 | Serum 25-hydroxyvitamin D,diabetes,and ethnicity in the Third National Health and Nutrition Examination Survey显示文摘 | Scragg R Sowers M Bell C | 2004 | Diabetes Care2004，27，： | 1 |
| 10 | BirA En- zyme: Production and Application in the Study of Mem- brane Receptor - Ligand Interactions by Site-Specific Biotinylation Original Research 显示文摘 | O'Callaghan C A Byford M F Wyer J R Willcox BE Jakobsen B K McMichael A J Bell J 1 | 1999 | Anal Biochem1999，266，1： | 1 |
| 11 | A comparison of complications associated with colostomy revered versus ileostomy reversal显示文摘 | Bell C Asolati M Hamilton E | 2005 | J Am Coll Surg2005，190，： | 1 |
| 12 | Dietary lipid enhancement of broodstock reproductive performance and egg and larval quality in Atlantic halibut(Hippoglossus hippoglossus)显示文摘 | Mazorra C Bruce M Bell J G | 2003 | Aquaculture2003，227，： | 1 |
| 13 | Assignment in the integration of urban traffic control and dynamic route guidance,in urban traffic networks dynamic flow modeling and control显示文摘 | Bell M G H Shield C M Anderson J M | 1995 | Springer-Verlag1995，，： | 1 |
| 14 | Diversity waveform sets for delay-Doppler imaging显示文摘 | Guey J C Bell M R | | 0，，4： | 1 |
| 15 | Optical sampling and demultiplexing applied to A/D conversion显示文摘 | Hamilton M C Leep D A | 1991 | Proc SPIE1991，1562，： | 1 |
| 16 | Magnetic resonance imaging of central nervous system lesions in patients withlupus erythematosus: correlation with clinical remission and antineurofilament and anticardiolipin titers 显示文摘 | Bell CL Partington C Robbins M | 1997 | Arthritis Rheum1997，34，5： | 1 |
| 17 | Laboratory and clinical experience in 55 patients with macroprolactinemia identified by a simple polyethylene glycol precipitation method 显示文摘 | Leslie H Courtney C H Bell P M | 2001 | J Clin Endocrinol Metab2001，86，6： | 1 |
| 18 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 19 | Origins of long-chain polyunsaturated fatty acids in the hydrothermal vent worms Ridgea pisceae and Protis hydrothermica显示文摘 | POND D W ALLEN C E BELL M V | 2002 | Marine Ecology Progress Series2002，225，： | 1 |
| 20 | Film Cooling From Shaped Holes 显示文摘 | Bell C M Hamakawa H Ligrani P M | 2000 | Journal of Turbomachinery2000，122，： | 1 |
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