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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?显示文摘当跟随主要人的 cytomegalovirus (HCMV ) 感染的主人免疫者反应在停止病毒复制和传播通常是有效的时,病毒从来没被主人并且象所有 herpesviruses 一样清除,永久坚持。至少部分地,这坚持被知道被 HCMV 的能力便于在感染是实质上沉默的与的 myeloid 在房间建立潜伏,重要地新病毒生产的全部的缺乏。然而,尽管病毒的抄写计划很在潜伏期间被压制,很多病毒的基因在蛋白质水平在潜伏的感染期间被表示,这些中的许多被显示了在潜伏的房间和它的环境上有深刻效果。有趣地,许多也在 lysin 的感染期间这些联系潜伏的基因被表示。因此,一样的有势力主人免疫者回答为什么在 lysin 的感染期间产生了到这些病毒的基因产品,没在潜伏期间被认出,从而允许隐而不见地的感染的房间的清理,是远非清楚的。从潜伏的复活也是调停 HCMV 的疾病的一个主要原因,特别地在损害的免疫者和免疫者天真,并且也是可能的是在被建议了与象动脉粥样硬化和一些瘤形成那样的长期的疾病被联系的长期的无临床症状的 HCMV 感染的病毒的主要来源。因而,理解潜伏并且隐而不见地的感染的房间为什么看起来是 immunoprivileged,为 HCMV 的致病的理解是关键的并且可以帮助设计策略消除潜伏的病毒水库,至少在某些临床的背景。 | Mark R Wills Emma Poole Betty Lau Ben Krishna John H Sinclair | 2015 | Cellular & Molecular Immunology2015，12，2： | 6 |
| 3 | Completeness of malaria notification in Tunisia assessed by capture recapture method显示文摘 | N Ben Alaya-Bouafif MK Chahed H El Bez H Bellali L Ayari N Achour | 2011 | Asian Pacific Journal of Tropical Disease2011，，3： | 2 |
| 4 | Responses of Spodoptera littoralis larvae to Tunisian plant extracts and to neo-clerodane diterpenoids isolated from Ajuga pseudoiva leaves显示文摘 | Ben J H Mighri Z Simmonds M S J | 2000 | Fitoteraoia2000，71，： | 1 |
| 5 | Use of Genetic Algorithms for Neural Networks to Predict Community-acquired Pneumonia显示文摘 | Paul S H Ben S G Thomas G T | 2004 | Artificial Intelligence in Medicine2004，30，： | 1 |
| 6 | Proteomic analysis of primary duck hepatocytes infected with duck hepatitis B virus显示文摘 | ZHAO Y BEN H QU S | 2010 | Proteome Sci2010，8，： | 1 |
| 7 | Responses of Spodoptera littoralis larvae to Tunisian plant extracts and to neo-clerodane diterpenoids isolated from Ajuga pseudoiva leaves显示文摘 | H Ben Jannet F Harzallah-Skhiri Z Mighri M.S.J Simmonds W.M Blaney | 2000 | Fitoterapia2000，，2： | 1 |
| 8 | Effects of different acupuncture stimula- tions on NO content in acupoint areas 显示文摘 | Ben H Rong PJ Li L | 2010 | J Tradit Chin Med2010，30，： | 1 |
| 9 | Effect of temperature on the performance of an anaerobic tubular reactor treating fruit and vegetable waste 显示文摘 | Bouallagui H Haouari O Touhami Y Ben Cheikh R Marouani L Hamdi M | 2004 | Process Biochemistry2004，39，12： | 1 |
| 10 | Thoracic myelopathy caused by ossifcation of the ligamentum fiavum: a report of 18 cases 显示文摘 | Ben Hamouda K Jemel H Haouet S | 2003 | J Neurosurg2003，2，： | 1 |
| 11 | Achard MF columnar liquid crystalline 3,4,9,10-tetra-(n-alkoxycarbonyl)-perylenes显示文摘 | Benning S Kitzerow HS Bock H | 2000 | Liquid Crystals2000，27，7： | 1 |
| 12 | Level of glycemic control and pregnancy outcome in type 1 diabetes: A comparison between multiple daily insulin injections and continuous subcutaneous insulin infusions显示文摘 | Chen R Ben H A Weismann B A | 2007 | Am J Obstet Gynecol2007，197，4： | 1 |
| 13 | Urinary IL-18 and NGAL as early predictive biomarkers in contrast-induced nephropathy after coronary angiography显示文摘 | Ling W Zhaohui N Ben H | 2008 | Nephron Clin Praet2008，108，3： | 1 |
| 14 | Reconfigurable distributed control using smart peripheral elements显示文摘 | Benítez-Pérez H García-Nocetti F | 2003 | Control Engineering Practice2003，11，9： | 1 |
| 15 | Bioreactor performance in anaerobic digestion of fruit and vegetable wastes 显示文摘 | Bouallagui H Touhami Y Ben Cheikh R | 2005 | Process Biochemistry2005，40，： | 1 |
| 16 | A robust timing and frequency synchronization for OFDM systems显示文摘 | H Minn V K Bhargava K Ben Letaief | 2003 | IEEE Trans Wireless Commun2003，2，4： | 1 |
| 17 | Polymers as soil conditioners under consecutive irrigation and rainfall显示文摘 | Ben H M Faris J Malik M | 1989 | Soil Science Society of America Journal1989，53，： | 1 |
| 18 | New insights to the MLL recombinome of acute leukemias显示文摘 | Meyer C Kowarz E Hofmann J Renneville A Zuna J Trka J Ben Abdelali R Macintyre E De Braekeleer E De Braekeleer M Delabesse E de Oliveira MP Cavé H Clappier E van Dongen JJ Balgobind BV van den Heuvel-Eibrink MM Beverloo HB Panzer-Grümayer R Teigler-Schleg | | 0，，08： | 1 |
| 19 | Pharma- colo Gical strategies against cold ischemia reperfusion injury显示文摘 | Zaouali MA Ben Abdennebi H Padrissa-Altes S | 2010 | Expert Opin Pharmacother2010，11，4： | 1 |
| 20 | Remote-con- trolled magnetic pulmonary vein isolation using a new three-dimensional non-fluoroscopic navigation system: a single-centre prospective study 显示文摘 | Da Costa A Ben H'dech M Romeyer-Bouchard C | 2013 | Arch Cardiovasc Dis2013，106，89： | 1 |
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