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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Management of infected pancreatic necrosis in the setting of concomitant rectal cancer:A case report and review of literature显示文摘BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant treatment and resection for his concomitant colorectal cancer. | Kihoon Choi David E Flynn Anitha Karunairajah Andrew Hughes Ambika Bhasin Benedict Devereaux Manju D Chandrasegaram | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 2 |
| 3 | Anterior spine fusion using Zielke instrumentation for adult thoracolumbar and lumbar scoliosis显示文摘 | Trammell TR Benedict F Reed D | 1991 | Spine1991，16，： | 1 |
| 4 | Cloning and expression of desoxyhemigossypol-6-O-methyltransferase from cotton ( Gossypium barbadense) 显示文摘 | Liu J Benedict C R Stipanovic R D | 2002 | Agric Food Chem2002，，： | 1 |
| 5 | Childhood obesity affects fine motor skill performance under different postural constraints 显示文摘 | D'HONDT E BENEDICTE D I1SE DB | 2008 | Neurosci Letters2008，440，1： | 1 |
| 6 | Bcl-xl interacts with Apaf-1and inhibits Apaf-1-dependent Caspase-9activation显示文摘 | Hu Y Benedict MA Wu D | 1998 | Proc Natl Acad Sci USA1998，95，8： | 1 |
| 7 | Stereotactic body radiation therapy: the report of AAPM Task Group 101显示文摘 | BENEDICT S H YENICE K M FOLLOWILL D | 2010 | Med Phys2010，37，8： | 1 |
| 8 | Bcl-XL interacts with Apaf-1 and inhibits显示文摘 | Benedict MA Wu D | 1998 | Proc Natl Acad Sci1998，95，： | 1 |
| 9 | Hydrological discharges and motion of fels and Black-Rapids Glaciers, Alaska, USA-Implications for the structure of their drainage systems 显示文摘 | Raymond C F Benedict R J Harrison W D | 1995 | Journal of Glaciology1995，41，138： | 1 |
| 10 | Expression and segregation of genes Cry1A insecticidal proteins in cotton 显示文摘 | SACHS E S BENEDICT J H STELLY D M et at | 1998 | Crop Sci1998，38，： | 1 |
| 11 | Negative feedback regulation of insulin-like growth factor-Ⅱ gene expression in differentiating myoblasts in vitro显示文摘 | Magri K A Benedict M R Ewton D Z | 1994 | Endocrinology1994，135，： | 1 |
| 12 | Poly( caprolectone)/clay nanocomposites prepared by melt intercalation:Mechanical, thermal and rheological properties 显示文摘 | Benedicte L Myrism D | 2002 | Polymer2002，43，14： | 1 |
| 13 | Stereotactic body radiation therapy: The report of AAPM Task Group 101显示文摘 | Benedict SH Yenice KM Followill D | 2010 | Med Phys2010，37，8： | 1 |
| 14 | Predicting complications after pulmonary resection- preoperative exercise testing vs a multifactorial cardiopulmonary risk index 显示文摘 | Epstein SK Faling LJ Benedict D | 1993 | Chest1993，104，3： | 1 |
| 15 | Cutting edge:a novel viral TNF receptor superfamily member in virulent strains of human eytomegalovirus 显示文摘 | Benedict C A Butrovich K D Lurain N S Corbeil J Roonev I Schneider P | 1999 | J Immunol1999，162，： | 1 |
| 16 | Negative feedback regulation of insulin-like growth factor 2 gene expression in differentiating my oblasts in vitro显示文摘 | Magri K A Benedict M R Ewton D Z | 1994 | Endocrinology1994，135，1： | 1 |
| 17 | Negative feedback regula- tion of insulin-like growth factor- Ⅱ gane expression in differentiating myoblasts in vitro显示文摘 | Magri K A Benedict M R Ewton D Z | 1994 | Endocrinology1994，135，1： | 1 |
| 18 | Esterification of lactic acid and ethanol with/without pervaporation显示文摘 | Benedict D J Parulekar S J Tsai S P | 2003 | Ind Eng Chem Res2003，42，： | 1 |
| 19 | Stereotactic body radiation therapy: the report of AAPM Task Group 101显示文摘 | Benedict SH Yenice KM Followill D | 2010 | Med Phys2010，37，8： | 1 |
| 20 | Stereotactic body radiation therapy:the report of AAPM Task Group 101显示文摘 | Benedict SH Yenice KM Followill D | 2010 | Med Phys2010，37，8： | 1 |
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