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| 1 | 论思维和STEM教育显示文摘随着全球化的STEM教育领域的迅速发展,各国对跨学科研究以及开发更新、更深入的STEM教育的学术研究的呼声也越来越高.文章聚焦思维这个话题,首先从历史发展的视角,简要概括分析了有关思维的不同观点,包括哲学的、心理的和学科的,揭示了思维概念和研究的历史传承.但在新兴的STEM教育背景下,思维需要重新概念化.文章提出了思维是多元的观点,初步探讨了STEM融合教育的这种方式,能够为学生提供充分的机会来有效地发展多元思维模式,并对未来关于思维的研究提出了可能的新研究领域和方向. | 李业平 SCHOENFELD A H DISESSA A A GRAESSER A C BENSON L C ENGLISH L D DUSCHL R A | 2019 | 数学教育学报2019，0，3： | 10 |
| 2 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 4 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 5 | Solid state phase tasnsitions in pentaerythritol and related polydric alcohols 显示文摘 | Benson D K Burrows R W Webb J D | 1986 | Sol Energ Mater1986，13，： | 2 |
| 6 | Machine vision-based guidance system for an agricultural small-grain harvester显示文摘 | BensonE R Reid J F Zhang Q | 2003 | Transactions of the ASAE2003，46，4： | 1 |
| 7 | Arsenic accumulation in great barrier reef invertebrates显示文摘 | BENSON A A Summons R E | 1981 | Science1981，211，： | 1 |
| 8 | Hyperbaric oxygen therapy of i- atrogenic cerebral arterial gas embolism 显示文摘 | Benson J Adkinson C Collier R | 2003 | Undersea Hyperbe Med2003，39，2： | 1 |
| 9 | Design, synthesis, and circu- lar dichroism investigation of a peptide--Sandwiched mesoheme 显示文摘 | Benson D R Hart B R Zhu X | 1995 | J Am Chem Soc1995，117，33： | 1 |
| 10 | Novel approaches to the diagnosis and treat- ment of breast cancer显示文摘 | Ismail J Benson J R | 2014 | Future Oncol2014，10，4： | 1 |
| 11 | Wild nodules can be broken: proteomics of Frankia in field-collected root nodules显示文摘 | Mastronunzio J E Benson D R | 2010 | Symbiosis2010，50，1： | 1 |
| 12 | Process for conver-ting hydrogen chloride to chlorine 显示文摘 | PanH Y Minet R G Benson S W | 1994 | Industrial & Engi-neering Chemistry Research1994，33，12： | 1 |
| 13 | White matter abnormalities in mobility-impaired older persons显示文摘 | Guttmann C Benson R Warfield S K | 2000 | Neurology2000，54，6： | 1 |
| 14 | Developmental evaluation of a potential non-steroidal estrogen: triclosan显示文摘 | FORAN C M BENNETT E R BENSON W H | 2000 | Marine Environmental Research2000，50，1： | 1 |
| 15 | Thermochemistry of Some Six-Membered Cyclic and Polycyclic Compounds Debated to Coal显示文摘 | Shaw R Golden D M Benson S W | 1977 | JPhys Chem1977，81，12： | 1 |
| 16 | Solid state phase transitions in pentaerythritol and related polyhydric alcohols显示文摘 | BENSON D K BURROWS R W WEBB J D | | 0，，02： | 1 |
| 17 | Sexually dimorphic sterility phe- notypes in Hoxal0-deficientmice显示文摘 | Satakata I Benson G Maas R | 1995 | Nature1995，374，6521： | 1 |
| 18 | Propagation and attenuation in the double- strip H guide显示文摘 | R F B Conlon and F A Benson | | Proc IEE0，1966，： | 1 |
| 19 | On-line immunoaffinity capture, coupled with HPLC and electrospray ionization mass spectrometry, for automated determination of fumonisins显示文摘 | NEWKIRK D K BENSON R W HOWARD P C | 1998 | J Agile and Food Chemisty1998，46，4： | 1 |
| 20 | Biology of Frankia strains, actinomycete symbionts of actinorhizal plants 显示文摘 | Benson D R Silvester W B | 1993 | Microbiological Reviews1993，57，： | 1 |
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