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5篇 您的检索式:作者名="Benting Ma"
    题名 作者 年代 出处 被引量
1The vacuum chest wall lift- er in the treatment of pectus excavatum 显示文摘Bente L Maninez MA Conde J 2006Cir Pediatr2006,19,1:1
2Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spotl4 and Cyp2e1 expression levels显示文摘Mitochondrion-localized retinol dehydrogenase 13 (Rdh13) is a short-chain dehydrogenase/reductase involved in vitamin A metabolism in both humans and mice. We previously generated Rdh13 knockout mice and showed that Rdh13 deficiency causes severe acute retinal light damage. In this study, considering that Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injury induced by carbon tetrachloride (CC14). Although Rdh13 deficiency showed no significant effect on liver histology and physiological functions under regular culture, the Rdh13^-/- mice displayed an attenuated response to CCl4-induced liver injury. Their livers also exhibited less histological changes and contained lower levels of liver-related metabolism enzymes compared with the livers of wild-type (WT) mice. Furthermore, the Rdhl3 1 mice had Rdh13 deficiency and thus their liver cells were protected from apoptosis, and the quantity of their proliferative cells became lower than that in WT after CC14 exposure. The ablation of Rdhl3 gene decreased the expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2el) in the liver, especially after CC14 treatment for 48 h. These data suggested that the alleviated liver damage induced by CC14 in Rdh13^-/- mice was caused by Cyp2el enzymes, which promoted reductive CC14 metabolism by altering the status of thyroxine metabolism. This result further implicated Rdhl3 as a potential drug target in preventing chemically induced liver injury.Xiaofang Cui Benting Ma Yan Wang Yan Chen Chunling Shen Ying Kuang Jian Fei Lungen Lu Zhugang Wang 2019Frontiers of Medicine2019,13,1:1
3End point assessment in gliomas: novel treatments limit usefulness of classical Macdonald's Criteria 显示文摘van den Bent M J Vogelbaum MA Wen PY 2009J Clin Oncol2009,27,18:1
4End point as- sessment in gliomas:novel treatments limit usefulness of classical Macdonald's Criteria显示文摘van den Bent MJ Vogelbaum MA Wen PY 2009J Clinical Oncology2009,27,18:1
5End pointassessment in gliomas: novel treatments limit usefulness ofclassical Macdonald's Criteria 显示文摘van den Bent MJ Vogelbaum MA Wen PY 2009J Clin Oncol2009,27,18:1
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