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| 1 | Combating echinococcosis in China:strengthening the research and development显示文摘Echinococcosis is a neglected zoonotic disease,causing great morbidity and mortality due to the wide distribution of its endemic areas.China holds a high percentage in the global burden of both cystic and alveolar echinococcosis.A national survey conducted between 2012 and 2016 showed that an estimated 50 million people are at risk of contracting the disease in western China,of whom about 0.17 million are cases with echinococcosis.Despite this,research and development on echinococcosis in China is greatly inadequate compared to that in other countries.In this paper,we argue that there is a need for more research and work to be conducted in China on echinococcosis,including researching techniques in regards to diagnosis,treatment,and vaccination,and developing products through technical transformation and piloting strategies to control and even elimination.However,great opportunities exist for China to strengthen the research and development on this disease through initiatives such as Health China 2030,the Belt and Road Initiative,the China-Africa cooperation,as well as through further cooperation between China and the World Health Organization.All of these can bring us closer to controlling echinococcosis in China as well as in other countries.One element of crucial importance will be the training and development of professionals,which can be strengthened through international cooperation. | Men-Bao Qian Bernadette Abela-Ridder Wei-Ping Wu Xiao-Nong Zhou | 2017 | Infectious Diseases of Poverty2017，6，1： | 31 |
| 2 | Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications显示文摘Rheumatoid arthritis(RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologictargets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics. | Lili Magyari Dalma Varszegi Erzsebet Kovesdi Patricia Sarlos Bernadett Farago Andras Javorhazy Katalin Sumegi Zsolt Banfai Bela Melegh | 2014 | World Journal of Orthopedics2014，5，4： | 17 |
| 3 | Aerosol Optical Properties and Its Radiative Forcing over Yulin, China in 2001 and 2002显示文摘The aerosol optical properties and direct radiative forcing over the Mu Us desert of northern China, acquired through a CE318 sunphotometer of the ground-based Aerosol Robotic Network (AERONET), are analyzed. The seasonal variations in the aerosol optical properties are examined. The effect of meteorological elements (pressure, temperature, water vapor pressure, relative humidity and wind speed) on the aerosol optical properties is also studied. Then, the sources and optical properties under two different cases, a dust event and a pollution event, are compared. The results show that the high aerosol optical depth (AOD) found in Yulin was mostly attributed to the occurrence of dust events in spring from the Mu Us desert and deserts of West China and Mongolia, as well as the impacts of anthropogenic pollutant particles from the middle part of China in the other seasons. The seasonal variation and the probability distribution of the radiative forcing and the radiative forcing effciency at the surface and the top of the atmosphere are analyzed and regressed using the linear and Gaussian regression methods. | 车慧正 张小曳 Stephane ALFRARO Bernadette CHATENET Laurent GOMES 赵剑琦 | 2009 | Advances in Atmospheric Sciences2009，26，3： | 11 |
| 4 | ANALYSIS OF COLUMN-INTEGRATED AEROSOL OPTICAL THICKNESS IN BEIJING FROM AERONET OBSERVATIONS显示文摘Aerosol Optical Thickness (AOT), water vapor content and derived Angstrom exponent acquired by a CIMEL sun photometer in Beijing are analyzed. Monthly means computed from quality-assured daily means, seasonal trends and inter-annual variations are presented and discussed. Summer has the highest seasonal average AOT at 440 nm (τa440), Angstrom exponent (α440–870) and water vapor content with the values 0.93, 1.34 and 3.0 cm, respectively. The second highest seasonal average τa440 appears in spring with the largest variation of α440–870 and minimum α440–870 0.99 due to the impact of coarse particles. The minimum seasonal average τa440 (0.44) and water vapor content (0.4 cm) appear in winter. The annual average τa440, α440–870 and water vapor content for about 4-year observation period are 0.70, 1.19 and 1.4 cm, respectively. All monthly average Angstrom exponents are within 0.8-1.4, which indicates aerosol in Beijing is a very complex mixture of both fine- and coarse-mode particles (from anthropogenic influence and natural mineral dust). | Xuehua Fan Hongbin Chen Philippe Goloub Xiang'ao Xia Wenxing Zhang Bernadette Chatenet | 2006 | China Particuology2006，4，6： | 9 |
| 5 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 6 | Selective serotonin reuptake inhibitors and Alzheimer’s disease显示文摘Given the failure to develop disease-modifying therapies for Alzheimer’s disease(AD),strategies aiming at preventing or delaying the onset of the disease are being prioritized.While the debate regarding whether depression is an etiological risk factor or a prodrome of AD rages on,a key determining factor may be the timing of depression onset in older adults.There is increasing evidence that untreated early-onset depression is a risk factor and that late-onset depression may be a catalyst of cognitive decline.Data from animal studies have shown a beneficial impact of selective serotonin reuptake inhibitors on pathophysiological biomarkers of AD including amyloid burden,tau deposits and neurogenesis.In humans,studies focusing on subjects with a prior history of depression also showed a delay in the onset of AD in those treated with most selective serotonin reuptake inhibitors.Paroxetine,which has strong anticholinergic properties,was associated with increased mortality and mixed effects on amyloid and tau deposits in mice,as well as increased odds of developing AD in humans.Although most of the data regarding selective serotonin reuptake inhibitors is promising,findings should be interpreted cautiously because of notable methodological heterogeneity between studies.There is thus a need to conduct large scale randomized controlled trials with long follow up periods to clarify the dose-effect relationship of specific serotonergic antidepressants on AD prevention. | Bernadette Mdawar Elias Ghossoub Rita Khoury | 2020 | Neural Regeneration Research2020，15，1： | 5 |
| 7 | GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees显示文摘 | Robert E. Lanford Bernadette Guerra Deborah Chavez Luis Giavedoni Vida L. Hodara Kathleen M. Brasky Abigail Fosdick Christian R. Frey Jim Zheng Grushenka Wolfgang Randall L. Halcomb Daniel B. Tumas | 2013 | Gastroenterology2013，，7： | 5 |
| 8 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 9 | An Empirical Investigation of the Relationship Between Change in Corporate Social Performance and Financial Performance: A Stakeholder Theory Perspective显示文摘 | Bernadette M. Ruf Krishnamurty Muralidhar Robert M. Brown Jay J. Janney Karen Paul | 2001 | Journal of Business Ethics2001，，2： | 4 |
| 10 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 11 | No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples显示文摘瞄准:当前的工作的目标细胞毒素的 T 淋巴细胞抗原是分析 +49A/G 的流行变体的在有 Crohn 的匈牙利病人的 4 基因(CTLA4 )?ˉs 疾病(CD ) 和 ulcerative (UC ) 。方法:有 CD 的 130 个无关的题目的一个总数并且 150 与 UC,和 170 匹配的控制是为单个核苷酸多型性(SNP ) 的 genotyped。遗传型被使用 PCR/RFLP 测试决定。结果:G 等位基因频率和 GG 遗传型的流行在 CD 组,是 38.1% 和 12.3%40.6% 和 18.6% 在 UC 病人,并且 37.4% 和 15.9% 在控制组分别地。结论:当前的学习的结果显示出 +49G SNP 的那辆马车在异质接合或不在匈牙利人口为 CD 或为 UC 在同型结合的形式授与风险任何一个。 | Lili Magyari Bernadett Faragó Judit Bene Katalin Horvatovich Lilla Lakner Márta Varga Mária Figler Beáta Gasztonyi Gyula Mózsik Béla Melegh | 2007 | World Journal of Gastroenterology2007，13，15： | 3 |
| 12 | A comparison of tracer kinetic models for T1‐weighted dynamic contrast‐enhanced MRI: Application in carcinoma of the cervix显示文摘 | Stephanie B.Donaldson Catharine M. L.West Susan E.Davidson Bernadette M.Carrington GillianHutchison Andrew P.Jones Steven P.Sourbron David L.Buckley | 2010 | Magn. Reson. Med2010，，3： | 2 |
| 13 | Guidelines for the Primary Prevention of Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B. Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Ed | 2014 | Stroke2014，，12： | 2 |
| 14 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 15 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 16 | Data and tools to integrate climate and environmental information into public health显示文摘Background:During the last 30 years,the development of geographical information systems and satellites for Earth observation has made important progress in the monitoring of the weather,climate,environmental and anthropogenic factors that influence the reduction or the reemergence of vector-borne diseases.Analyses resulting from the combination of geographical information systems(GIS)and remote sensing have improved knowledge of climatic,environmental,and biodiversity factors influencing vector-borne diseases(VBDs)such as malaria,visceral leishmaniasis,dengue,Rift Valley fever,schistosomiasis,Chagas disease and leptospirosis.These knowledge and products developed using remotely sensed data helped and continue to help decision makers to better allocate limited resources in the fight against VBDs.Main body:Because VBDs are linked to climate and environment,we present here our experience during the last four years working with the projects under the,World Health Organization(WHO)/The Special Programme for Research and Training in Tropical Diseases(TDR)-International Development Research Centre(IDRC)Research Initiative on VBDs and Climate Change to integrate climate and environmental information into research and decision-making processes.The following sections present the methodology we have developed,which uses remote sensing to monitor climate variability,environmental conditions,and their impacts on the dynamics of infectious diseases.We then show how remotely sensed data can be accessed and evaluated and how they can be integrated into research and decision-making processes for mapping risks,and creating Early Warning Systems,using two examples from the WHO TDR projects based on schistosomiasis analysis in South Africa and Trypanosomiasis in Tanzania.Conclusions:The tools presented in this article have been successfully used by the projects under the WHO/TDRIDRC Research Initiative on VBDs and Climate Change.Combined with capacity building,they are an important piece of work which can significantly contribute to the goals of WHO Global Vector Control Response and to the Sustainable Development Goals especially those on health and climate action. | Pietro Ceccato Bernadette Ramirez Tawanda Manyangadze Paul Gwakisa Madeleine C.Thomson | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 17 | Subclinical thyroid disease显示文摘 | David S Cooper Bernadette Biondi | 2012 | 2012 (9821)2012，，9821： | 2 |
| 18 | 指南溃疡性结肠炎的管理:NICE指南更新汇总显示文摘溃疡性结肠炎是一种以直肠和结肠黏膜炎症为特征的慢性炎症性疾病,可导致腹泻(软便伴排次增加)、便血、便急迫和腹痛症状。炎症通常累及直肠及直肠近端不同范围的结肠。直肠的炎症称为直肠炎,直肠和乙状结肠的炎症称为直乙结肠炎。左半结肠炎是指疾病累及脾曲以远的结肠。广泛结肠炎是指疾病范围达到脾曲近端的结肠,甚至全结肠累及时的全结肠炎。 | Omnia Abdulrazcg Bernadette Li Jenny Epstein 舒慧君(译) | 2020 | 英国医学杂志中文版2020，23，7： | 2 |
| 19 | Advanced glycation endproducts and their receptor RAGE in Alzheimer’s disease显示文摘 | Velandai Srikanth Annette Maczurek Thanh Phan Megan Steele Bernadette Westcott Damian Juskiw Gerald Münch | 2009 | Neurobiology of Aging2009，，5： | 2 |
| 20 | The Trends in Maternal Mortality between 1996 and 2009 in Guizhou, China: Ethnic Differences and Associated Factors显示文摘China bears a large burden of global maternal mortality, and the largest burden of maternal deaths in China is in poor western provinces. This study aimed to investigate the trends in maternal mortality and its associated factors in Guizhou province of western China between 1996 and 2009, and examine differences between minority and non-minority counties. A population-based, longitudinal, retrospective study was performed in a poor western province of China with a considerably large ethnic minority population. All 86 counties/districts of Guizhou were included with population at county, township and village level. Maternal mortality data were collected from routine reporting database of Guizhou Provincial Health Bureau. Trend and comparative analyses and multivariate linear regression analyses were performed using SPSS 17.0. Maternal mortality ratio(MMR) and its change over time, differences between ethnic groups were analyzed. A declining trend in maternal mortality and rising trend in hospital delivery in Guizhou was observed; ethnic differences between two ethnic groups persisted. The reduction in maternal mortality between 1996 and 2009 was related with increased gross domestic product, decreased male illiteracy rate, and increased hospital delivery rate. We found the declining trends in maternal mortality in Guizhou with persisting ethnic differences. The declining trends are related with economic development, hospital delivery and male illiteracy. Effective health education on maternal health is urgently needed for the minority groups, and basic education for the new generation should be enhanced to eradicate the illiteracy. | 杜清 练武 ?yvind Nss Espen Bjertness Bernadette Nirmal Kumar 石淑华 | 2015 | Journal of Huazhong University of Science and Technology(Medical Sciences)2015，35，1： | 2 |
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