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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 3 | Usefulness of biodegradable polydioxanone stents in the treatment of postsurgical colorectal strictures and fistulas显示文摘 | F. Pérez Roldán P. González Carro M. Villafá?ez García S. Aoufi Rabih M. Legaz Huidobro N. Sánchez-Manjavacas Mú?oz O. Roncero García-Escribano M. Ynfante Ferrús E. Bernardos Martín F. Ruiz Carrillo | 2012 | Endoscopy2012，，03： | 2 |
| 4 | Lessons from the ( ' Iressa' expanded access programme: Gefitinib in special non-small-cell lung cancer patient populations 显示文摘 | Stahel R Rossi A Petruzelka L Kosimidis P de Braud F Bernardo MM | 2003 | Br J Cancer2003，89，2： | 1 |
| 5 | Phase Ⅲ trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: an intergroup trial(E1193) 显示文摘 | Sledge GW Neuberg D Bernardo P | 2003 | J Clin Oncol2003，21，4： | 1 |
| 6 | RFLP-based estimates of parental contribution to F2- and BCi_ de-rived maize inbreds 显示文摘 | Bernardo R Murigneux A Maisonneuve J P | 1997 | Theoretical and Applied Genetics1997，94，： | 1 |
| 7 | Bifurcations of dynamical systems with sliding: derivation of normal form mapping显示文摘 | di Bernardo M Kowalczyk P Nordmark A | 2002 | Phys D2002，170，17： | 1 |
| 8 | Randomized phase Ⅲ trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy:Eastern Cooperative Oncology Group trial E2196显示文摘 | Sparano JA Bernardo P Stephenson P | 2004 | J Clin Oncol2004，22，23： | 1 |
| 9 | Membrane gas separation: A review state of the art显示文摘 | Bernardo P Drioli E Golemme G | 2009 | Industrial & Engineering Chemistry Research2009，48，10： | 1 |
| 10 | Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of eastern cooperative oncology group 5592, a randomized trial显示文摘 | Langer CJ Manola J Bernardo P | 2002 | J Natl Cancer Inst2002，94，3： | 1 |
| 11 | Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: eastern cooperative oncology group trial E2196 显示文摘 | Sparano JA Bernardo P Stephenson P | 2004 | J Clin Oncol2004，22，： | 1 |
| 12 | Membrane gas separation:A review/state of the art显示文摘 | Bernardo P Drioli E Golemme G | | 0，，10： | 1 |
| 13 | Architecting families of software systems with process algebras 显示文摘 | Bernardo M Ciancarini P Donatiello L | 2002 | ACM Trans on Software Engineering and Methodology2002，11，4： | 1 |
| 14 | Macro-and-micro-cellular porous ceramics from preceramic polymers显示文摘 | Colombo P Bernardo E | 2003 | Composites Science and Technology2003，63，16： | 1 |
| 15 | Judicious resection and radio surgery for parasagittal meningiomas:outcome from amulticenter review显示文摘 | DOUGLAS K JOHN C F BERNARDO P | 1998 | Neurosurgery1998，43，2： | 1 |
| 16 | Randomized phase Ⅲ trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy:Eastern Cooperative Oncology Group trial E2196显示文摘 | SPARANO J A BERNARDO P STEPHENSON P | 2004 | J Clin Oncol2004，22，23： | 1 |
| 17 | Cisplain-based therapy for elderly patients with advanced non-small cell lung cancer:implications of eastern cooperative oncology group 5592,a randomized trial显示文摘 | Langer CJ Manola J Bernardo P | 2002 | J Natl Cancer Inst2002，94，： | 1 |
| 18 | Architecling families of software systems with process algebras 显示文摘 | Bernardo M Ciancarini P Donatiello L | 2002 | ACM Transactions on Software Engineering and Methodology2002，11，4： | 1 |
| 19 | Diaphragmmatic eventration:long-term follow-up and results of open-chest plicature显示文摘 | Calvinho P Bastos C Bernardo JE | | 0，，05： | 1 |
| 20 | Marques advances in thermoplastic matrix towpregs processing 显示文摘 | Nunes J P Van Hattum F W J Bernardo C A | 2003 | Journal of Thermoplastic ''Composite Materials2003，17，6： | 1 |
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