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| 1 | Targeted therapy for advanced gastric cancer: A review of current status and future prospects显示文摘In the West in particular, the vast majority of gastric cancer(GC) patients present with advanced-stage disease. Although combination chemotherapy is stillthe most important component of treatment for these patients, it confers a modest survival advantage. Recently, increased knowledge of the key molecular signaling pathways involved in gastric carcinogenesis has led to the discovery of specific molecular-targeted therapeutic agents. Some of these agents such as trastuzumab and ramucirumab have changed the treatment paradigm for this disease. In this paper, we will summarize the current clinical status of targeted drug therapy in the management of GC. | Ozkan Kanat Bert O'Neil Safi Shahda | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 2 | Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor显示文摘SRC-3/AIB1 (在乳癌 1 的类固醇受体激活剂 3/amplified ) 是在癌症病人贡献药抵抗和差的没有疾病的幸存的发展的真 oncogene。Autophagy 也是让肿瘤 suppressor 工作的重要房间死亡机制。在这研究,我们识别了巨噬细胞移植禁止的因素(MIF ) 作为 SRC-3 的新奇目标基因并且在房间幸存表明了它的重要性。明确地,我们证明 MIF 是 autophagic 房间死亡的强壮的 suppressor。我们进一步证明接着, MIF 的抑制导致了 autophagic 房间死亡,提高了 chemosensitivity 并且禁止了在一个异种皮移植老鼠 tumorigenesis 模型的 tumorigenesis。我们的学习证明 MIF 表示的那条规定和 autophagic 房间死亡的抑制是 SRC-3 由贡献增加的 chemoresistance 和 tumorigenicity 的有势力机制。 | Mei-Yi Wu Junjiang Fu Jianming Xu Bert W O'MaUey Ray-Chang Wu | 2012 | Cell Research2012，22，6： | 12 |
| 3 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 4 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 5 | Intra-annual variations in climate influence growth and wood density of Norway spruce显示文摘 | BOUR1AUD O LEBAN J M BERT D | 2005 | Tree physiology2005，25，： | 1 |
| 6 | Nuclear Receptor Coregulators:Cellular and Molecularn显示文摘 | Lanz B Bert W O'Maller | 1997 | Biology Endocrine Reviews1997，20，3： | 1 |
| 7 | Prognosis of elderly patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention in 2001 to 2011: A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) registry显示文摘 | Velders M A James S K Libungan B Sarno G Fr?bert O Carlsson J | 2014 | Am Heart J2014，167，： | 1 |
| 8 | Lower risk of stent thrombosis and restenosis with unrestricted use of'newgeneration'drug-eluting stents:a report from the nationwide Swedish Coronary Angiography and Angioplasty Registry(SCAAR)显示文摘 | Sarno G Lagerqvist B Frbert O | 2012 | Eur Heart J2012，33，5： | 1 |
| 9 | Intraannual variations in climate influence growth and wood density of Norway spruce显示文摘 | Bouriaud O Leban J - M Bert D | 2005 | Tree Physiology2005，25，6： | 1 |
| 10 | The response of root/shoot partitioning and root morphology to light reduction in maize genotypes显示文摘 | Hébert Y Guingo E Loudet O | 2001 | Crop Science2001，41，2： | 1 |
| 11 | Nuclear receptors and coregulators:an introduction显示文摘 | McKenna NJ Bert W O'Malley BW | 2003 | NURSA e-J2003，1，1： | 1 |
| 12 | Thrombus aspiration during ST-segment elevation myocardial infarction显示文摘 | Fr?bert O Lagerqvist B Olivecrona GK | | 0，，17： | 1 |
| 13 | Water to atmosphere fluxes of 131 I in relation with alkyl-iodide compounds from the Seine Estuary(France)显示文摘 | Connan O Tessier E Maro D Amouroux D He’bert D Rozet M Voiseux C Solier L | 2008 | Journal of Environmental Radioactivity2008，99，： | 1 |
| 14 | Genotype differences in behavior andtyrosine hydroxylase expression between wild-type and progesterone receptor knockout mice显示文摘 | Sarah C Woo lley Bert O'Malley | 2006 | Behavioural Brain Research2006，167，2： | 1 |
| 15 | The response of root/shoot partitioning and root morphology to light reduction in maize genotypes显示文摘 | Hébert Y Guingo E Loudet O | 2001 | Crop Science2001，41，2： | 1 |
| 16 | Nuclear receptor coregulators: cellular and molecularn显示文摘 | Lanz B Bert W O | 1997 | Biology Endocrine Reviews1997，20，3： | 1 |
| 17 | A case of respiratory epithelial adenomatoid hamartoma显示文摘 | Jonathan Liang Bert W. O’Malley Michael Feldman Jason G. Newman | 2007 | American Journal of Otolaryngology--Head and Neck Medicine and Surgery2007，，4： | 1 |
| 18 | Genotype differences in behavior and tyrosine hydroxylase expression between wild-type and progesterone receptor knockout mice显示文摘 | Sarah C Woolley Bert O | 2006 | Behavioural Brain Research2006，167，28： | 1 |
| 19 | Soilfertility evaluation and management by smallholder farmer com- munities in northern Tanzania 显示文摘 | Jeremias G Mowoa Bert H J Oene O | 2006 | Agriculture Ecosys- tems & Environment2006，116，12： | 1 |
| 20 | Plant oil renewable resources as green ahematives in poly- mer science 显示文摘 | MICHAEL A R MEIER JORGEN O METZGER ULRICH S SCHU- BERT | 2007 | Chemical Society Reviews2007，，36： | 1 |
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