|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 2 | Characterization of the Yeast Transcriptome显示文摘 | Victor E Velculescu Lin Zhang Wei Zhou Jacob Vogelstein Munira A Basrai Douglas E Bassett Phil Hieter Bert Vogelstein Kenneth W Kinzler | 1997 | Cell1997，，2： | 4 |
| 3 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 4 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 5 | Computational models for sandwich panels and shells显示文摘 | Noor A K Burton W S Bert C W | 1996 | Applied Mechanics Reviews1996，4，3： | 1 |
| 6 | Differential quadrature analysis of deflection, buckling and vibration of beams and rectangular plates 显示文摘 | Wang X Bert C W Stirz A G | 1993 | Computers & Structures1993，48，3： | 1 |
| 7 | Two merger integration imperatives: Urgency and execution显示文摘 | Bert A MacDonald T Herd T | 2003 | Strategy and Leadership2003，37，： | 1 |
| 8 | Regional Activation of the Cancer Genome by Long-Range Epigenetie Remodeling显示文摘 | BERT S A ROBINSON M D STRBENAC D | 2012 | Cancer Cell2012，23，1： | 1 |
| 9 | Solution of the improved and generalized quasistatic methods using an analytic calculation or a semiimplicit scheme to compute the precursor equations显示文摘 | KOCLAS J SISSAOUI M T H BERT A | 1996 | Ann Nucl Energy1996，23，11： | 1 |
| 10 | Mi-croRNAs as regulators of epithelial-mesenchymal tran-sition显示文摘 | Gregory P A Bracken C P Bert A G Goodall G J | 2008 | Cell Cycle2008，7，： | 1 |
| 11 | The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1显示文摘 | GREGORY P A BERT A G PATERSON E L | 2008 | Nature Cell Biolo- gy2008，10，5： | 1 |
| 12 | Stable isotopic evidence for climate and basin evolu- tion of the Late Cretaceous Songliao basin, China 显示文摘 | Chamberlain C P Wan X Q Graham S A Carroll A R Doeb- bert A C Sageman B B Blisniuk P Kent-Corson M L Wang Z Wang C S | 2013 | Palaeo- geogr Palaeoclimatol Palaeoecol2013，385，： | 1 |
| 13 | Accessibility evaluation of land-use and transport strategies: review and research directions显示文摘 | Karst T Geurs a Bert van Wee b | 2004 | Journal of Transport Geography2004，，12： | 1 |
| 14 | Inactivation of parvovirus B19 during STIM-4 vapor heat treatment of three coagulation factor concentrates 显示文摘 | Berting A Modrof J Unger U | 2008 | Transfusion2008，48，6： | 1 |
| 15 | Systemic accident risk assessment in air traffic by Monte Carlosimulation显示文摘 | Sybert H Stroeve Henk A P Blom G J(Bert)Bakker | 2009 | Safety Science2009，47，2： | 1 |
| 16 | Iron Based Flame Retarding/Smoke Suppressing Compounds for PVC 显示文摘 | Lecomte L Bert M Michel A Guyot A | 1977 | JMacromol Sci-Chem1977，11，： | 1 |
| 17 | Rapid identifica-tion of CBFβ-MYH11 positive acute myeloid leukemia (AML) cases by one single MYHll real-time RT-PCR 显示文摘 | Bert A van der Reijden Marion M | 2003 | Blood2003，101，： | 1 |
| 18 | Differential quadrature analysis of deflection, bucking, and free vibration of beams and rectangular plates显示文摘 | Wang X Bert C W Striz A G | 1993 | Computers & Structures1993，48，3： | 1 |
| 19 | Analysis of heavy metals in liquids using laser induced breakdown spectroscopy by liquid-to-solid matrix conversion显示文摘 | Diaz Pace D M D'Angelo C A Bert uccelli D | 2006 | Spectrochimica Acta Part B2006，61，8： | 1 |
| 20 | Catalyst-Free Growth of GaN Nanowires显示文摘 | Bertness K A Sanford N A Barker J M | 2006 | J Electron Mater2006，35，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员