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| 1 | G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis显示文摘Estrogens play important roles in the development and progression of multiple tumor types.Accumulating evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly understood.Studies on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative colitis.GPER is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC cells.Thus,multiple lines of evidence suggest that GPER may play an important role in colorectal carcinogenesis.In this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC. | Damian Jacenik Ellen J Beswick Wanda M Krajewska Eric R Prossnitz | 2019 | World Journal of Gastroenterology2019，25，30： | 6 |
| 2 | NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat显示文摘 | Beswick R A Dorrance A M Leite R | 2001 | Hypertension2001，38，5： | 1 |
| 3 | NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat 显示文摘 | Beswick R Dorrance AM Leite R | 2001 | Hypertension2001，35，5： | 1 |
| 4 | NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat显示文摘 | Beswick RA Dorrance AM Leite R | 2001 | Hypertension2001，38，： | 1 |
| 5 | NADH/NADPH oxidase and enhanced superoxide production in the minerallc orticoid hypertensive rat显示文摘 | Beswick RA Dorrance AM Leite R | 2001 | Hypertension2001，38，： | 1 |
| 6 | Exogenous TERC alone can enhance proliferative potential, telomerase activity and te- lomere length in lymphocytes from dyskeratosis congenita patients显示文摘 | Kirwan M Beswick R Vulliamy T | 2009 | Br J Haematol2009，144，5： | 1 |
| 7 | Effectiveness of the GOFER course in decision making for high school students 显示文摘 | Mann L Harmoni R Power C Beswick G Ormond C | 1988 | Journal of Behavioral Decision making1988，，1： | 1 |
| 8 | What propor- tion of patients report long-term pain after total hip or knee re- placement for osteoarthritis? A systematic review of prospective studies in unselected patients 显示文摘 | Beswick AD Wylde V Gooberman-Hill R | 2012 | BMJ Open2012，2，1： | 1 |
| 9 | ICOS ligand costimulation is required for T-cell encephalitogenicity显示文摘 | Sporici R A Beswick R L von Allmen C | 2001 | Clin Immunol2001，100，3： | 1 |
| 10 | Oxygen detection using Lang- muir-Blodgett films of a metalloporphyrin显示文摘 | Beswick R B Pitt C W | 1988 | Chemical Physics Letters1988，143，： | 1 |
| 11 | Complex interventions to improve physical function and maintain independent living in elderly people:A systematic review and meta-analysis显示文摘 | Beswick A.D Rees K Dieppe P Ayis S Gooberman-Hill R Horwood J & Ebrahim S | | 0，，： | 1 |
| 12 | NADHYNADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat显示文摘 | Beswick RA Dorrance AM Leite R | 2001 | Hypertension2001，38，5： | 1 |
| 13 | Improving uptake and adherence in cardiac rehabilitation:Literature review 显示文摘 | Beswick A D Rees K West R R | 2005 | J Adv Nurs2005，49，5： | 1 |
| 14 | NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat显示文摘 | Beswick RA Dorrance AM Leite R | 2001 | Hyperternsion2001，38，： | 1 |
| 15 | ICOS ligand costimulation is required for T-call encephalitogenicity显示文摘 | Sporici R A Beswick R L von-Allmen C | 2001 | Clin Immunol2001，100，3： | 1 |
| 16 | Differences in disease sever- ity but similar telomere lengths in genetic subgroups of patients with te- lomerase and sheherin mutations显示文摘 | Vulliamy TJ Kirwan MJ Beswick R | 2011 | PLoS One2011，6，24： | 1 |
| 17 | NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat显示文摘 | Beswick RA Dorrance AM Leite R | 2001 | Hypertension2001，38，： | 1 |
| 18 | TINF2 mutations result in very short telomeres : analysis of a large cohort of patients with dysk- eratosis congenita and related bone marrow failure syndromes 显示文摘 | Walne A J Vulliamy T Beswick R | 2008 | Blood2008，112，9： | 1 |
| 19 | TINF2 mutations result in very short telomeres:analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes显示文摘 | Walne AJ Vulliamy T Beswick R Kirwan M Dokal I | | 0，，09： | 1 |
| 20 | What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? Asystematic review of prospective studies in unse|ected patients显示文摘 | Beswick AD Wylde V Gooberman-Hill R | 2012 | BMJ Open2012，2，00： | 1 |
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