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| 1 | Liver transplantation in alcoholic liver disease current status and controversies显示文摘Alcoholic cirrhosis remains the second most common indication for liver transplantation.A comprehensive medical and psychosocial evaluation is needed when making a decision to place such patients on the transplant list.Most transplant centers worldwide need a minimum of 6 mo of alcohol abstinence for listing these patients.Patients with alcohol dependence are at high risk for relapse to alcohol use after transplantation(recidivism).These patients need to be identified and require alcohol rehabilitation treatment before transplantation.Recidivism to the level of harmful drinking is reported in about 15%-20%cases.Although,recurrent cirrhosis and graft loss from recidivism is rare,occurring in less than 5%of all alcoholic cirrhosis-related transplants,harmful drinking in the post-transplant pe-riod does impact the long-term outcome.The development of metabolic syndrome with cardiovascular events and de novo malignancy are important contributors to non liver-related mortality amongst transplants for alcoholic liver disease.Surveillance protocols for earlier detection of de novo malignancy are needed to improve the long-term outcome.The need for a minimum of 6 mo of abstinence before listing makes transplant a nonviable option for patients with severe alcoholic hepatitis who do not respond to corticosteroids.Emerging data from retrospective and prospective studies has challenged the 6 mo rule,and beneficial effects of liver transplantation have been reported in select patients with a first episode of severe alcoholic hepatitis who are unresponsive to steroids. | Ashwani K Singal Khushdeep S Chaha Khalid Rasheed Bhupinderjit S Anand | 2013 | World Journal of Gastroenterology2013，19，36： | 12 |
| 2 | Management of hepatitis C virus infection in HIV/HCV co-infected patients: Clinical review显示文摘Nearly one fourth of individuals with human immunodeficiency virus (HIV) infection have hepatitis C virus (HCV) infection in the US and Western Europe. With the availability of highly active antiretroviral therapy and the consequent reduction in opportunistic infections, resulting in the prolongation of the life span of HIV-infected patients, HCV co-infection has emerged as a signif icant factor influencing the survival of HIV patients. Patients with HIV/HCV co-infection have a faster rate of fibrosis progression resulting in more frequent occurrences of cirrhosis, end-stage liver disease, and hepatocellular carcinoma. However, the mechanism of interaction between the two viruses is not completely understood. The treatment for HCV in co-infected patients is similar to that of HCV monoinfection; i.e., a combination of pegylated interferon and ribavirin. The presence of any barriers to antiHCV therapy should be identified and eliminated in order to recruit all eligible patients. The response to treatment in co-infected patients is inferior compared to the response in patients with HCV mono-infection. The sustained virologic response rate is only 38% for genotype-1 and 75% for genotype-2 and -3 infections. Liver transplantation is no longer considered a contraindication for end-stage liver disease in coinfected patients. However, the 5 year survival rate is lower in co-infected patients compared to patients with HCV mono-infection (33% vs 72%, P = 0.07). A better understanding of liver disease in co-infected patients is needed to derive new strategies for improving outcome and survival. | Ashwani K Singal Bhupinderjit S Anand | 2009 | World Journal of Gastroenterology2009，15，30： | 12 |
| 3 | Definition,epidemiology and magnitude of alcoholic hepatitis显示文摘Alcoholic liver disease(ALD) is a major cause of alcoholrelated morbidity and mortality.Its presentation ranges from fatty liver to alcoholic hepatitis(AH),cirrhosis,and hepatocellular carcinoma.Although the amount and pattern of alcohol consumption is a well recognized predisposing factor for the development of serious liver pathology,environmental factors and the host's genetic makeup may also play significant roles that have not yet been entirely explored.Continuing alcohol consumption is a major factor that influences the survival of patients with AH.The presence of cirrhosis at presentation or its development on follow up is a major factor determining the outcome in the long run.This chapter deals with the epidemiology and magnitude of ALD in general and AH in particular. | Sarpreet Basra Bhupinderjit S Anand | 2011 | World Journal of Hepatology2011，3，5： | 11 |
| 4 | Alcoholic hepatitis and concomitant hepatitis C virus infection显示文摘Hepatitis C virus(HCV)infection and alcohol abuse are two most important causes of chronic liver disease in the United States.Alcoholic hepatitis is a unique clinical syndrome among patients with chronic and active alcohol abuse with a potential for high short-term mortality.About 20%of patients presenting with alcoholic hepatitis have concomitant HCV infection.Mortality from alcoholic hepatitis is increased in the presence of concomitant hepatitis C due to synergistic interaction between HCV and alcohol in causing hepatocellular damage.Large prospective randomized studies are needed to develop guidelines on the use of corticosteroids among patients with alcoholic hepatitis and concomitant HCV infection.The impact of antiviral therapy on mortality and outcome in the setting of alcoholic hepatitis remains a novel area for future research. | Mohamed Shoreibah Bhupinderjit S Anand Ashwani K Singal | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 5 | Waist-to-Hip Ratio, but Not Body Mass Index, is Associated with an Increased Risk of Barrett’s Esophagus in White Men显示文摘 | Jennifer R. Kramer Lori A. Fischbach Peter Richardson Abeer Alsarraj Stephanie Fitzgerald Yasser Shaib Neena S. Abraham Maria Velez Rhonda Cole Bhupinderjit Anand Gordana Verstovsek Massimo Rugge Paola Parente David Y. Graham Hashem B. El-Serag | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 6 | Waist-to-Hip Ratio, but Not Body Mass Index, is Associated with an Increased Risk of Barrett’s Esophagus in White Men显示文摘 | Jennifer R. Kramer Lori A. Fischbach Peter Richardson Abeer Alsarraj Stephanie Fitzgerald Yasser Shaib Neena S. Abraham Maria Velez Rhonda Cole Bhupinderjit Anand Gordana Verstovsek Massimo Rugge Paola Parente David Y. Graham Hashem B. El-Serag | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 7 | Hepatitis C virus infection in alcoholic hepatitis: prevalence patterns and impact on in-hospital mortality显示文摘 | Ashwani K. Singal Yong-Fang Kuo Bhupinderjit S. Anand | 2012 | European Journal of Gastroenterology & Hepatology2012，，10： | 1 |
| 8 | Colorectal cancer in African Americans显示文摘 | Agrawal S Bhupinderjit A Bhutani M | | American Journal of Gastroenterology0，，： | 1 |
| 9 | Hepatitis C virus infection in alcoholic hepatitis: prevalence patterns and impact on in-hospital mortality显示文摘 | Ashwani K. Singal Yong-Fang Kuo Bhupinderjit S. Anand | 2012 | European Journal of Gastroenterology & Hepatology2012，，10： | 1 |
| 10 | Outcomes after liver transplantation for alcoholic hepatitis are similar to alcoholic cirrhosis: Exploratory analysis from the UNOS database显示文摘 | Ashwani K. Singal Hmoud Bashar Bhupinderjit S. Anand Sarat C. Jampana Vineet Singal Yong‐Fang Kuo | 2012 | Hepatology2012，，5： | 1 |
| 11 | Outcomes after liver transplantation for combined alcohol and hepatitis C virus infection显示文摘Alcohol abuse and chronic hepatitis C virus(HCV)infection are two major causes of chronic liver disease in the United States.About 10%-15%of liver transplants performed in the United States are for patients with cirrhosis due to combined alcohol and HCV infection.Data on outcomes on graft and patient survival,HCV recurrence,and relapse of alcohol use comparing transplants in hepatitis C positive drinkers compared to alcohol abuse or hepatitis C alone are conflicting in the literature.Some studies report a slightly better overall outcome in patients who were transplanted for alcoholic cirrhosis vs those transplanted for HCV alone or for combined HCV and alcohol related cirrhosis.However,some other studies do not support these observations.However,most studies are limited to a retrospective design or small sample size.Larger prospective multicenter studies are needed to better define the outcomes in hepatitis C drinkers. | Rashid Khan Ashwani K Singal Bhupinderjit S Anand | 2014 | World Journal of Gastroenterology2014，20，34： | 0 |
| 12 | General aspects of the treatment of alcoholic hepatitis显示文摘General measures for treating patients with alcoholic hepatitis(AH) are similar irrespective of the disease severity.Alcohol abstinence is the cornerstone of treatment and can be achieved with appropriate social support,Alcoholics Anonymous and sometimes pharmacological therapy.Alcohol withdrawal should be anticipated and treatment initiated to prevent this complication.Treatment for complications of cirrhosis should be as for any other patient with cirrhosis.AH patients are particularly prone to infections and malnutrition.These should be identified and treated appropriately using broad spectrum antibiotics and nutritional support respectively. | Michael J Babineaux Bhupinderjit S Anand | 2011 | World Journal of Hepatology2011，3，5： | 0 |
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