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| 1 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 2 | Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire ( LCQ ) 显示文摘 | Birring SS Prudon B Cart A J | 2003 | Thorax2003，，58： | 1 |
| 3 | Development of a symptom specific health status measure for patients with chronic cough:leicester cough questionnaire(LCQ)显示文摘 | Birring S S Prudon B Carr A J | 2003 | Thorax2003，58，： | 1 |
| 4 | Physician dual practice显示文摘 | Eggleston K Bir A | | 0，，02： | 1 |
| 5 | Two bacterial strains isolated from a Zn-polluted soil enhance plant growth and my- corrhizal efficiency under Zn - toxicity 显示文摘 | Vivas A Bir B Ruiz- Lozano J M | 2006 | Chemosphere2006，62，9： | 1 |
| 6 | Use of telech- elic cis-1, 4-pnlyisoprene cationomers in the synthesis of anti- bacterial ionic polyurethanes and eopolyurethanes bearing ant- monium groups 显示文摘 | K BIR N CAMPISTRON I I AGUERRE A | 2007 | Biomaterials2007，28，： | 1 |
| 7 | Role of carboplatin in the treatment of triple negative early-stage breast cancer 显示文摘 | Valsecchi ME Kimmey G Bir A | 2015 | Rev Recent Clin Trials2015，10，2： | 1 |
| 8 | New therapeutic approach for impaired arteriogenesis in diabetic mouse hindlimb ischemia显示文摘 | Bir SC Fujita M Marui A | 2008 | Circ J2008，72，4： | 1 |
| 9 | Expression of extradomain-Bcontaining fibronectin in subretinal choroidal neovascular membranes显示文摘 | Nicolà M Birò A Cardillo-Piccolino F | | 0，，： | 1 |
| 10 | Physician Dual Practice显示文摘 | EGGLESTON K BIR A | 2006 | Health Policy2006，78，23： | 1 |
| 11 | Angiogenic properties of sustained release platelet-rich plasma: characterization in-vitro and in the ischemic hind limb of the mouse 显示文摘 | Bir SC Esaki J Marui A | 2009 | J Vasc Surg2009，50，4： | 1 |
| 12 | New therapeutic approach for impaired arteriogenesis in diabetic mouse hindlimb ischemia显示文摘 | Bir SC Fujita M Marui A | 2008 | Circ J2008，72，4： | 1 |
| 13 | Potential utility of 1363 expression in differential diagnosis of non - small - cell lung carcinoma and its effect on prognosis of the disease 显示文摘 | Bir F Aksoy Altinboga A Satiroglu Tufan NL | 2014 | Med Sci Monitor2014，20，： | 1 |
| 14 | Reactive oxygen species,redox signaling and neuroinflammation in Alzheimer's disease:the NF-kappaB connection显示文摘 | KAUR U BANERJEE P BIR A | 2015 | Curr Top Med Chem2015，15，5： | 1 |
| 15 | Ascorbic acid (vi- tamin C) and iloprost attenuate the lung injury caused by ischemia/reperfusion of the lower extremities of rats显示文摘 | Bahalarli A Ozcan V Bir F | 2006 | Ann Vase Surg2006，20，1： | 1 |
| 16 | Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ) 显示文摘 | Birring SS Prudon B Carr A J | 2003 | Thorax2003，58，4： | 1 |
| 17 | Ascorbic acid(vitamin C)and iloprost attenuate the lung injury caused by ischemia/reperfusion of the lower extremities of rats显示文摘 | Baltalarli A Ozcan V Bir F | 2006 | Ann Vasc Surg2006，20，1： | 1 |
| 18 | Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ) 显示文摘 | Birring S S Prudon B Carr A J | 2003 | Thorax2003，58，4： | 1 |
| 19 | Biomechanics of thehead for Olympic boxer punches to the face显示文摘 | WALILKO T J VIANO D C BIR C A | 2005 | Sports Med2005，39，10： | 1 |
| 20 | Angiogenic properties of sustained release platelet-rich plasma: characterization in-vitro and in the is- chemic hind limb of the mouse 显示文摘 | Bir SC Esaki J Marui A | 2009 | J Vasc Surg2009，50，4： | 1 |
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