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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study显示文摘 | Bengt Winblad Niels Andreasen Lennart Minthon Annette Floesser Georges Imbert Thomas Dumortier R Paul Maguire Kaj Blennow Joens Lundmark Matthias Staufenbiel Jean-Marc Orgogozo Ana Graf | 2012 | Lancet Neurology2012，，7： | 3 |
| 4 | Alzheimer’s disease显示文摘 | Kaj Blennow Mony J de Leon Henrik Zetterberg | 2006 | The Lancet . 2006 (9533)2006，，9533： | 2 |
| 5 | Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study显示文摘 | Oskar Hansson Henrik Zetterberg Peder Buchhave Elisabet Londos Kaj Blennow Lennart Minthon | 2006 | Lancet Neurology2006，，3： | 2 |
| 6 | CSF markers for incipient Alzheimer’s disease显示文摘 | Kaj Blennow Harald Hampel | 2003 | Lancet Neurology2003，，10： | 2 |
| 7 | Alzheimer’s disease显示文摘 | Kaj Blennow Mony J de Leon Henrik Zetterberg | 2006 | 2006 (9533)2006，，9533： | 2 |
| 8 | Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants 显示文摘 | Blennow M Savman K Ilves P | 2001 | Acta Paediatr2001，90，10： | 2 |
| 9 | Analysis of intact proteins from cerebrospinal fluid by matrix-assisted laser desorption/ioniaation mass spectromtry after two-dimensional liquid-phase electrophoresis 显示文摘 | Westman A Blennow K | 1999 | Rapid Communications in Mass Spectrometry1999，13，： | 1 |
| 10 | Increased cerebrospinal fluid levels of transforming growth factor- betal in Alzheimer~s disease 显示文摘 | Zetterberg I-I Andreasen N Blennow K | | Neurosci Lett0，367，2： | 1 |
| 11 | Sensory and rheological properties of transgenically and chemically modified starch ingredients as evaluated in a food product model显示文摘 | Ahmt T Wischmann B Blennow A | 2004 | Nahrung2004，48，2： | 1 |
| 12 | Decreased cerehrospinal fluid acetylchollnesterase in patients with subcortical ischemlc vascular dementia 显示文摘 | Wallin A Sjogren M Blennow K | 2003 | Dement Geriatr Cogn Disord2003，16，4： | 1 |
| 13 | Alzheiner's disease显示文摘 | BLENNOW K DE LEON MJ ZETTERBERG H | 2006 | Lancet2006，368，9533： | 1 |
| 14 | Early surfactant ad-ministration with brief ventilation vs selective surfactant and contin-ued mechanical ventilation for preterm infants with or at risk for re-spiratory distress syndrome显示文摘 | Stevens TP Harrington EW Blennow M | 2007 | Cochrane Database Syst Rev2007，17，00： | 1 |
| 15 | The neuropathology and neurobiology of traumatic brain injury显示文摘 | Blennow K Hardy J Zetterberg H | | 0，，： | 1 |
| 16 | CSF biomarkers for mild cognitive impairment and early Alzheimer’s disease显示文摘 | Niels Andreasen Kaj Blennow | 2004 | Clinical Neurology and Neurosurgery2004，，3： | 1 |
| 17 | Swedish survey on extra structurally abnormal chromosomes in 39,105 consecutive prenatal diagnoses:prevalence and characterization by fluorescence in situ hybridization 显示文摘 | Blennow E Bui T H Kristoffersson U | 1994 | Prenat Diagn1994，14，： | 1 |
| 18 | Cytokine response in cerebrospinal fluid after birth asphyxia显示文摘 | Savman K Blennow M Gustafson K Tarkowski E Hagberg H | 1998 | Pediatr Res1998，43，6： | 1 |
| 19 | Swedish survey on extra structurally abnormal chromosomes in 39105 consecutive prenatal diagnoses: Prevalence and characterization by fluores- cence in situ hybridization 显示文摘 | Blennow E Bui TH Kristoffersson U | 1994 | Prenatal Diagn1994，14，： | 1 |
| 20 | Starch molecular structure and phosphorylation investigated by a combined chromatographic and chemometric approach 显示文摘 | Blennow A Engelsen S B Munck L | 2000 | Carbohydrate Polymers2000，2，： | 1 |
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