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| 1 | Positron emission tomography to assess hypoxia and perfusion in lung cancer显示文摘In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with decreased perfusion, perfusion measurements provide more insight into the relation between hypoxia and perfusion in malignant tumors. Positron emission tomography(PET) is a highly sensitive nuclear imaging technique that is suited for non-invasive in vivo monitoring of dynamic processes including hypoxia and its associated parameter perfusion. The PET technique enables quantitative assessment of hypoxia and perfusion in tumors. To this end, consecutive PET scans can be performed in one scan session. Using different hypoxia tracers, PET imaging may provide insight into the prognostic significance of hypoxia and perfusion in lung cancer. In addition, PET studies may play an important role in various stages of personalized medicine, as these may help to select patients for specifictreatments including radiation therapy, hypoxia modifying therapies, and antiangiogenic strategies. In addition, specific PET tracers can be applied for monitoring therapy. The present review provides an overview of the clinical applications of PET to measure hypoxia and perfusion in lung cancer. Available PET tracers and their characteristics as well as the applications of combined hypoxia and perfusion PET imaging are discussed. | Eline E Verwer Ronald Boellaard Astrid AM van der Veldt | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 2 | Experimental and c linical evaluati on of iterative reconstruction (OSEM) in dynamic PET: quantitative characteristi cs and effects on kinetic modeling显示文摘 | Van Lingen A Lammertsma AA | 2001 | Nucl Med2001，42，： | 1 |
| 3 | Standards for PET image acquisition and quantitative data analysis显示文摘 | Boellaard R | 2009 | J Nucl Med2009，50，1： | 1 |
| 4 | Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial显示文摘 | Krak NC Boellaard R Hoekstra OS | 2005 | Eur J Nucl Med Mol Imaging2005，32，3： | 1 |
| 5 | Comparison oftranscranial Doppler ultrasonography and positron emissiontomography using a three-dimensional template of themiddle cerebral artery 显示文摘 | Rijbroek A Boellaard R Vriens EM | 2009 | Neurol Res2009，31，1： | 1 |
| 6 | Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography显示文摘 | Odile A. van den Heuvel Dick J. Veltman Henk J. Groenewegen Raymond J. Dolan Danielle C. Cath Ronald Boellaard Catalina T. Mesina Anton J.L.M. van Balkom Patricia van Oppen Menno P. Witter Adriaan A. Lammertsma Richard van Dyck | 2004 | Psychiatry Research: Neuroimaging2004，，3： | 1 |
| 7 | Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions显示文摘 | Rik Ossenkoppele Wiesje M. van der Flier Sander C.J. Verfaillie Hugo Vrenken Adriaan Versteeg Ronald A. van Schijndel Sietske A. Sikkes Jos Twisk Sofie M. Adriaanse Marissa D. Zwan Ronald Boellaard Albert D. Windhorst Frederik Barkhof Philip Scheltens Adr | 2014 | Neurology2014，，20： | 1 |
| 8 | Through- wafer copper electroplating for three-dimensional interconnects 显示文摘 | NGUYEN N T BOELLAARD E PHAM N P | 2002 | Journal of Micromechanics and Microengineering2002，12，4： | 1 |
| 9 | 18FDG uptake in oesophageal adenocarcinoma: linking biology and outcome显示文摘 | Marinke Westerterp Gerrit W. Sloof Otto S. Hoekstra Fiebo J. W. Kate Gerrit A. Meijer Johannes B. Reitsma Ronald Boellaard J. Jan B. Lanschot Carla F. M. Molthoff | 2008 | Journal of Cancer Research and Clinical Oncology2008，，2： | 1 |
| 10 | Microglial activation in Alzheimer's disease:an(R)-[11C]PK11195positron emission tomography study显示文摘 | Schuitemaker A Kropholler MA Boellaard R | | 0，，： | 1 |
| 11 | Test-retest variability of quantitative PIB studies in Alzheimer's disease显示文摘 | Tolboom N Yaqub M Boellaard R | 2009 | Eur J Nucl Med Mol Imaging2009，36，： | 1 |
| 12 | Integration of FDG- PET/CT into external beam radiation therapy planning Technical aspects and recommendations on methodological approaches 显示文摘 | Thorwarth D Beyer T Boellaard R | 2012 | Nukleamledizin2012，51，4： | 1 |
| 13 | Integrated solenoid inductors with patterned,sputter-deposited Cr/Fe10Co90/Cr ferromagnetic cores显示文摘 | Rejaei B Boellaard E | 2003 | IEEE Electron Device Letters2003，24，4： | 1 |
| 14 | Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial显示文摘 | Krak N C Boellaard R Hoekstra O S | 2005 | Eur J Nucl Med Mol Im- aging2005，32，3： | 1 |
| 15 | Integrated solenoid inductors with patterned sputter-deposited Cr/Fe10 Co90/Cr ferromagnetic cores显示文摘 | Zhuang Y Rejaei B Boellaard E | 2003 | IEEE Electron Device Lett2003，24，： | 1 |
| 16 | Standardised FDG uptake:a prognostic factor for inoperable non-small cell cancer显示文摘 | Borst GR Belderbos JS Boellaard R | 2005 | Eur J Cancer2005，41，11： | 1 |
| 17 | Standardised FDG up- take: a prognostic factor for inoperable non-small cell lung cancer 显示文摘 | Borst GR Belderbos JS Boellaard R | 2005 | Eur J Cancer2005，41，11： | 1 |
| 18 | Assessment of tumour size in PET/CT lung cancer studies: PET - and CT - based methods compared to pathology显示文摘 | CHEEBSUMON P BOELLAARD R DE RUYSSCHER D | 2012 | EJNMMI Res2012，2，1： | 1 |
| 19 | Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: A simulation study显示文摘 | Boellaard R Krak NC Hoekstra OS | 2004 | J Nucl Med2004，45，9： | 1 |
| 20 | The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials显示文摘 | Boellaard R Oyen WJ Hoekstra CJ | 2008 | Eur J Nucl Med Mol Imag- ing2008，35，12： | 1 |
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