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| 1 | E-waste environmental contamination and harm to public health in China显示文摘人的身体上的电子废物(电子浪费) 的不利效果在最近的年里煽动了担心。中国是面对严肃的污染和电子浪费的人的暴露的国家之一,并且人口的多数暴露于从再循环过程的非正式的电子浪费被导出的潜在地危险的物质。这研究在中国在人的暴露上考察最近的报告到电子浪费,与暴露线路的特别焦点(例如,吸入和摄取) 并且人的几毒性(例如,内分泌的系统,呼吸系统,繁殖系统,发展毒性, neurotoxicity,和基因毒性) 。一些有在中国的人的健康效果的伙伴电子浪费暴露被估计的证据。有毒的重金属的角色(例如,铅,镉,铬,水银,和镍)并且器官的污染物质(例如, polybrominated diphenyl 醚( PBDE ), polychlorinated 联本基(印刷电路板),多不的芳香的烃(哼), polybrominated 联本基( PBB ), polyhalogenated 芳香的烃( PHAH ), bisphenol A ( BPA ))在人上,健康简短也被讨论。 | Xijin Xu Xiang Zeng H. Marike Boezen Xia Huo | 2015 | Frontiers of Medicine2015，9，2： | 6 |
| 2 | Tacrolimus and mycophenolate mofetil as second-line treatment in autoimmune hepatitis:Is the evidence of sufficient quality to develop recommendations?显示文摘BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were performed.We calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for MMF.The pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for MMF.Pooled biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),respectively.Moreover,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment groups.CONCLUSION Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement. | Mohammadreza Abdollahi Neda Khalilian Ekrami Morteza Ghojazadeh H Marike Boezen Mohammadhossein Somi Behrooz Z Alizadeh | 2020 | World Journal of Gastroenterology2020，26，38： | 5 |
| 3 | Toll-like re-ceptor(TLR2 and TLR4)polymorphisms and chronic ob-structive pulmonary disease 显示文摘 | Budulac SE Boezen HM Hiemstra PS | 2012 | PLoS One2012，7，43： | 1 |
| 4 | Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes显示文摘 | Marjan Kerkhof H. Marike Boezen Raquel Granell Alet H. Wijga Bert Brunekreef Henri?tte A. Smit Johan C. de Jongste Carel Thijs Monique Mommers John Penders John Henderson Gerard H. Koppelman Dirkje S. Postma | 2014 | The Journal of Allergy and Clinical Immunology2014，，1： | 1 |
| 5 | The insulin-like growth factor 1 receptor in cancer: old focus, new future显示文摘 | Hartog H Wesseling J Boezen HM | 2007 | Eur J Cancer2007，43，13： | 1 |
| 6 | Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer显示文摘 | Ninke Leffers Marloes J. M. Gooden Renske A. Jong Baukje-Nynke Hoogeboom Klaske A. Hoor Harry Hollema H. Marieke Boezen Ate G. J. Zee Toos Daemen Hans W. Nijman | 2009 | Cancer Immunology Immunotherapy2009，，3： | 1 |
| 7 | Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD显示文摘 | Dijkstra AE Boezen HM van den Berge M | 2015 | Eur RespirJ2015，45，1： | 1 |
| 8 | A disinte grin and metalloprotease 33 and chronic obstructive pulmona ry disease pathophysiology显示文摘 | Gosman MM Boezen HM van Diemen CC etal | 2007 | Thorax2007，62，3： | 1 |
| 9 | The insulin-like growth factor 1 receptor in cancer:old focus,new future显示文摘 | Hartoq H Wesseling J Boezen HM | 2007 | Eur J Cancer2007，43，13： | 1 |
| 10 | Preventive intervention possibilities in radiotherapy - and chemotherapy - induced oral mucositis : results of meta - analyses 显示文摘 | Stokman MA Spijkervet FK Boezen HM | 2006 | J Dent RES2006，85，： | 1 |
| 11 | Gender differences in respiratory symptoms in 19-year-old adults born preterm显示文摘 | Vrijlandt E J Gerritsen J Boezen HM | 2005 | Respir Res2005，6，： | 1 |
| 12 | 显示文摘 | Jongepier H Boezen HM Dijkstra A | 2004 | Clin Exp Allergy2004，34，5： | 1 |
| 13 | Phase Ⅱ study of docetaxel and carboplatin as second-line treatment in NSCLC显示文摘 | Wachters FM van Putten JW Boezen HM | 2004 | Lung Cancer2004，45，2： | 1 |
| 14 | The insulin-like growth factor 1 receptor in cancer: old focus, new future 显示文摘 | Hartog H Wesseling Boezen HM | 2007 | Eur J Cancer2007，43，13： | 1 |
| 15 | Dissecting thegenetics of chronic mucus hypersecretion in smokers with andwithout COPD显示文摘 | Dijkstra AE Boezen HM van den Berge M | 2015 | Eur Respir J2015，45，1： | 1 |
| 16 | Preventive Intervention Possibilities in Radiotherapyand ChemotherapyInduced Oral Mucositia: Result of MetaAnalyses显示文摘 | Stokman M A Spijkervet F K L Boezen H M | 2006 | J Dental Res2006，85，8： | 1 |
| 17 | Self-efficacy for physical activity and insight into its benefits are modifiable fac- tors associated with physical activity in people with COPD: A mixed-methods study 显示文摘 | Hartman J Hacken NHT Boezen HM | 2013 | J Physiother2013，59，2： | 1 |
| 18 | Physical and psychosocial factors associated with physical activity in pa- tients with chronic obstructive pulmonary disease 显示文摘 | Hartman JE Boezen HM de Greef MH | 2013 | Arch Phys Med Rehabil2013，94，12： | 1 |
| 19 | Expression of multidrug resistance-associated proteins predicts prognosis in childhood and adult acute显示文摘 | Plasschaert SL de Bont ES Boezen M | 2005 | Clin Cancer Res2005，11，241： | 1 |
| 20 | Respiratory health in prematurely born preschool children with and without bronchopulmonary dysplasia显示文摘 | Vrijlandt EJ Boezen HM Gerritsen J | 2007 | Pediatr2007，150，3： | 1 |
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