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| 1 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 2 | Light metal hydrides and complex hydrides for hydrogen storage显示文摘 | Schuth F Bogdanovic B Felderhoff M | 2004 | Chemical Communications2004，20，： | 1 |
| 3 | Thermodynamic investigation of the magnesium-hydrogen system显示文摘 | Bogdanovíc B Bohmhammel K Christ B | 1999 | J Alloys Compd1999，282，： | 1 |
| 4 | Ti-doped alkali metal aluminium hydrides as potential novel reversible hydrogen storage material 显示文摘 | BOGDANOVIC B SCHWICKARDI M | 1997 | J Alloys Compd1997，253，： | 1 |
| 5 | Ti-doped NaAlH4 as a hydrogen storage material preparation by Ti-catalyzed hydrogenation of aluminum powder in conjunction with sodium hydride显示文摘 | Bogdanovic B Schwickardi M | 2001 | Applied Physics a-Materials Science & Processing2001，72，： | 1 |
| 6 | Advanced hydrogen-storage materials based on Sc-,Ce-,and Pr-doped NaAlH4显示文摘 | Bogdanovic B Felderhoff M Pommerin A Schuth T Spielkamp N | 2006 | Advanced Materials2006，18，： | 1 |
| 7 | Ti-doped alkali metal aluminium hydrides as potential novel reversible hydrogen storage material 显示文摘 | BOGDANOVIC B SCHW/CKARDI M | 1997 | J Alloys Compd1997，253，： | 1 |
| 8 | Proteomics by FTICR mass spectrometry: top down and bottom up 显示文摘 | BOGDANOV B SMITH R D | 2005 | Mass Spectrometry Reviews2005，24，2： | 1 |
| 9 | Improved hydrogen storage properties of Ti-doped sodium alanate using titanium nanoparticles as doping agents 显示文摘 | BOGDANOVIC B FELDERHOFF M KASKEL S POMMER/N A SCHLICHTE K SCHUTH F | 2003 | Adv Mater2003，15，12： | 1 |
| 10 | High Temperature Metal Hydrides as Heat Storage Materials for Solar and Related Applications显示文摘 | Felderhoff M Bogdanovic B | 2009 | International Journal of Molecular Sciences2009，10，1： | 1 |
| 11 | Understanding the functions of plant disease resistance proteins显示文摘 | Martin G B Bogdanove A J Sessa G | 2003 | Annu Rev Plant Biol2003，54，： | 1 |
| 12 | Improved hydrogen storage properties of Ti- doped sodium alanate using titanium nanoparticles as doping agents 显示文摘 | BOGDANOVIC B FELDERHOFF M KASKEL S | 2003 | Adv Mater2003，15，12： | 1 |
| 13 | J AlloyCompd显示文摘 | Bogdanovic B FelderhofT M Pommerin A | 2009 | 471: 3832009，471，： | 1 |
| 14 | Accumulation of cyclin-de- pendent kinase 5 (cdk5) in neurons with early sta- ges of Alzheimer's disease neurofibrillary degenera- tion显示文摘 | Pei J J Grundke-lqbal I Iqbal K Bogdanovic N Winblad B Cowburn RF | 1998 | Brain Res1998，797，2： | 1 |
| 15 | AvrPto-dependent Pro-interacting proteins and AvrPto-interacting proteins in tomato显示文摘 | Bogdanove A J Martin G B | 2000 | Proc Natl Acad Sci U S A2000，97，16： | 1 |
| 16 | Erythropoietin protectsfrom reperfusion- induced myocardial injury by enhancing coronaryendothelial nitric oxide production 显示文摘 | Mihov D Bogdanov N Grenacher B | 2009 | Eur J Cardiothorac Surg2009，35，5： | 1 |
| 17 | The application of Mgbased metal-hydrides as heat energy storage systems显示文摘 | Reiser A Bogdanovic B Schlichte K | 2000 | International Journal of Hydrogen Energy2000，25，： | 1 |
| 18 | Ti-doped alkali metal aluminium hydrides as potential novel reversible hydrogen storage materials显示文摘 | BOGDANOVIC B SCHWlCKARDI M | 1997 | J Alloys Compd1997，253，： | 1 |
| 19 | Investigation of hydrogen discharging and recharging processes of Ti-doped NaAlH4 by X-ray diffraction analysis (XRD) and solid-state NMR spectroscopy 显示文摘 | BOGDANOVIC B FELDERHOFF M GERMANN M HARTEL M POMMERIN A SCHUTH F WEIDENTHALER C ZIBROWIUS B | 2003 | J Alloys Compd2003，350，： | 1 |
| 20 | Metal-doped sodium aluminium hydrides as potential new hydrogen storage materials 显示文摘 | BOGDANOVIC B BRAND R A MARJANOVICA SCHWICKARDI M TOLLE J | 2000 | J Alloys Compd2000，302，： | 1 |
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