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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | The effects of mineral supplementation to ewes in late pregnancy on eolostrum yield and immunoglobulin G absorption in their lambs显示文摘 | Boland T M Brophy P O Callan J J | 2005 | Livestock Production Science2005，97，23： | 1 |
| 3 | Organ printing:Computer-aided jet-based 3D tissue engineering显示文摘 | Mironv V Boland T Trusk T | 2003 | Trends in Biotechnology2003，21，4： | 1 |
| 4 | Limitations of conventional methods of self- monitoring of blood glucose显示文摘 | Boland E Monsod T Delucia M | 2001 | Diabetes Care2001，24，11： | 1 |
| 5 | Cell and organ printing I:Protein and cell printers显示文摘 | Cris W Wilson J R Boland T | 2003 | The Anatomical Record Part A2003，272，2： | 1 |
| 6 | Cardiovascular risk factors and cognitive decline in middle-aged adults 显示文摘 | Knopman D Boland LL Mosley T | 2001 | Neurology2001，56，1： | 1 |
| 7 | Cell and organ printing II:Fusion of cell aggregates in three-dimensional gels显示文摘 | Boland T Mironov V Gutowska A | 2003 | The Anatomical Record Part A2003，272，2： | 1 |
| 8 | Limitations of conventional methods of self-monitoring of blood glucose lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes显示文摘 | Boland E Monsod T Delucia M | 2001 | Diabetes Care2001，24，11： | 1 |
| 9 | Organ printing, computer-aided jet-based 3D tissue engineerlng显示文摘 | Mironov V Boland T Trusk T | 2003 | Trends Biotechnol2003，21，4： | 1 |
| 10 | Limitations of conventional methods of self-monitoring of blood glucose: lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes显示文摘 | Boland E Monsod T Delucia M | 2001 | Diabetes Care2001，24，： | 1 |
| 11 | Cell and organ printing 2 : Fusion of cell aggregates in three-dimensional gels 显示文摘 | Boland T Mironov V Gutowska A | 2003 | Anatomical Record Part a-Discoveries in Molecular Cel- lular and Evolutiunary Biology2003，272，2： | 1 |
| 12 | Limitations of con-ventional methods of self-monitoring of blood glucose显示文摘 | Boland E Monsod T Delucia M | 2001 | Diabetes Care2001，24，11： | 1 |
| 13 | Limitions of conventional methods self-monitoring of blood glucose显示文摘 | Boland E Monsod T Delucia M | | 0，，： | 1 |
| 14 | Limitations of conventional methods of self-monitoring of blood glucose显示文摘 | BOLAND E MONSOD T TELUCIA M | 2001 | Diabetes Care2001，24，10： | 1 |
| 15 | Drop-on-demand priming of cells and materials for designer tissue con- structs显示文摘 | BOLAND T TAO X DAMON B J | 2007 | Materials Science and Engineering: C2007，27，3： | 1 |
| 16 | Participation of protein kinase C alpha in 1,25-dihydroxy-vitamin D3 regulation of chick myoblast proliferation and differentiation显示文摘 | Capiati D A Tellez-Inon M T Boland R L | 1999 | Mol Cell Endocrinol1999，153，： | 1 |
| 17 | Sediment oxygen consumption and benthic nutrient fluxes on the Louisiana continental shelf:A methodological comparison显示文摘 | MILLER-W T BOLAND G S TWILLEY R R | 1994 | Estuaries1994，17，： | 1 |
| 18 | A review of the non-targeteffects of fungi used to biologically control plant dis-eases显示文摘 | Brimner T A Boland G J | 2003 | Agriculture Ecosystems&Environment2003，100，1： | 1 |
| 19 | Organ printing computer-aided jet-based 3D tissue engineering显示文摘 | Mironov V Boland T Trusk T | 2003 | TRENDS in Biotechnology2003，21，4： | 1 |
| 20 | Mycelial growth and production of ox- alic acid by virulent and hypovirulent isolates of Sclerotinia sclerotiorum 显示文摘 | Zhou T Boland G J | 1999 | Can J Plant Pathol1999，21，： | 1 |
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