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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | MMP and TIMP alterations in asymptomatic and symptomatic severe recurrent carotid artery stenosis显示文摘 | Sapienza P Borrelli V di Marzo L | 2009 | Eur J Vasc Endovasc Surg2009，37，5： | 1 |
| 3 | Bread crust melanoidins aspotential prebiotic ingredients 显示文摘 | Borrelli R C* Fogliano V | 2005 | Molecular Nutritionand Food Research2005，49，： | 1 |
| 4 | Thrombin induces production of growth factors from aortic smooth muscle cells显示文摘 | Cucina A Borrelli V Di Carlo A | 1999 | J Surg Res1999，82，： | 1 |
| 5 | Metalloproteinases and their inhibitors are markers of plaque instability显示文摘 | di Marzo L Borrelli V | 2005 | Surgery2005，137，： | 1 |
| 6 | Autotrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin - induced mitogenesis in smooth muscle cells 显示文摘 | Cucina A Borrelli V Lucarelli M | 2002 | Cell Biochem Funct2002，20，： | 1 |
| 7 | The ozone paradox: ozone is a strong oxidant as well as a medical drug显示文摘 | Bocci V Borrelli E Travagli V | 2009 | M ed Res Rev2009，29，4： | 1 |
| 8 | Bread crust melanoldins as potential prebiotic ingredients显示文摘 | BORRELLI R C FOGLIANO V | 2005 | Molecular Nutrition&Food Research2005，49，7： | 1 |
| 9 | Characterization of melanoidins from a glucose-glycine model system显示文摘 | BORRELLI R FOGLIANO V Monti S M | 2002 | European Food Research and Technology2002，215，3： | 1 |
| 10 | Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cells 显示文摘 | Cucina A Borrelli V Lucarelli M | 2002 | Cell Biochem Funct2002，20，： | 1 |
| 11 | The ozone paradox: ozone is a strong oxidant as well as a medical drug显示文摘 | Bocci V Borrelli E Travagli V | 2009 | Med Res Rev2009，29，4： | 1 |
| 12 | The ozone paradox:ozone is a strong oxidant as well as a medical drug显示文摘 | Bocci V Borrelli E Travagli V | 2009 | Med Res Rev2009，29，4： | 1 |
| 13 | The ozone para- dox: ozone is a strong oxidant as well as a medical drug显示文摘 | BOCCI V BORRELLI E TRAVAGLI V | 2009 | Med Res Rev2009，29，4： | 1 |
| 14 | Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells 显示文摘 | CUCINA A BORRELLI V RANDONE B | 2003 | The Journal of Surgical Research2003，109，1： | 1 |
| 15 | The ozone paradox:ozone is a strong oxidant as well as a medical drug显示文摘 | Bocci V Borrelli E Travagli V | | 0，，4： | 1 |
| 16 | MMP and TIMP Alterations in Asymptomatic and Symptomatic Severe Recurrent Carotid Artery Stenosis 显示文摘 | Sapienza P Borrelli V di Marzo L | 2009 | Eur J Vasc Endovasc Surg2009，37，5： | 1 |
| 17 | Thrombin induces production of growth factors from aortic smooth muscle cells 显示文摘 | Cucina A Borrelli V Di Carlo A | 1999 | J Surg Res1999，82，1： | 1 |
| 18 | Thermal degradation studies of food melanoidins显示文摘 | Adams A Borrelli R C Fogliano V F | 2005 | J Agric Food Chem2005，53，10： | 1 |
| 19 | Role of gastroesophageal reflux in children with unexplained chronic cough显示文摘 | Borrelli O Marabotto C Mancini V | 2011 | J Pediatr Gastroenterol Nutr2011，53，3： | 1 |
| 20 | Oxidised LDI,(oxLDL) induces production of platelet derived growth factor AA ( PDGF AA) from aortic smooth muscle cells显示文摘 | Cucina A Pagliei S Borrelli V | 1998 | Eur J Vasc Endovasc Surg1998，16，3： | 1 |
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