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| 1 | Efficient genome editing in plants using a CRISPR/Cas system显示文摘 | Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu | 2013 | Cell Research2013，23，10： | 211 |
| 2 | Application of the CRISPR-Cas System for Efficient Genome Engineering in Plants显示文摘 | Mao, Yanfei Zhang, Hui Xu, Nanfei Zhang, Botao Gou, Feng Zhu, Jian-Kang | 2013 | Molecular Plant2013，6，6： | 132 |
| 3 | Changes in Mean and Extreme Temperature and Precipitation over the Arid Region of Northwestern China: Observation and Projection显示文摘This paper reports a comprehensive study on the observed and projected spatiotemporal changes in mean and extreme climate over the arid region of northwestern China, based on gridded observation data and CMIP5 simulations under the RCP4.5 and RCP8.5 scenarios. The observational results reveal an increase in annual mean temperature since 1961, largely attributable to the increase in minimum temperature. The annual mean precipitation also exhibits a significant increasing tendency. The precipitation amount in the most recent decade was greater than in any preceding decade since 1961. Seasonally,the greatest increase in temperature and precipitation appears in winter and in summer, respectively. Widespread significant changes in temperature-related extremes are consistent with warming, with decreases in cold extremes and increases in warm extremes. The warming of the coldest night is greater than that of the warmest day, and changes in cold and warm nights are more evident than for cold and warm days. Extreme precipitation and wet days exhibit an increasing trend, and the maximum number of consecutive dry days shows a tendency toward shorter duration. Multi-model ensemble mean projections indicate an overall continual increase in temperature and precipitation during the 21 st century. Decreases in cold extremes, increases in warm extremes, intensification of extreme precipitation, increases in wet days, and decreases in consecutive dry days, are expected under both emissions scenarios, with larger changes corresponding to stronger radiative forcing. | Yujie WANG Botao ZHOU Dahe QIN Jia WU Rong GAO Lianchun SONG | 2017 | Advances in Atmospheric Sciences2017，34，3： | 37 |
| 4 | Ultrastable single-atom gold catalysts with strong covalent metal-support interaction (CMSI)显示文摘Supported noble metal nanoparticles (including nanoclusters) are widely used in many industrial catalytic processes. While the finely dispersed nanostructures are highly active, they are usually thermodynamically unstable and tend to aggregate or sinter at elevated temperatures. This scenario is particularly true for supported nanogold catalysts because the gold nanostructures are easily sintered at high temperatures, under reaction conditions, or even during storage at ambient temperature. Here, we demonstrate that isolated Au single atoms dispersed on iron oxide nanocrystallites (Aul/FeOx) are much more sintering- resistant than Au nanostructures, and exhibit extremely high reaction stability for CO oxidation in a wide temperature range. Theoretical studies revealed that the positively charged and surface-anchored Aul atoms with high valent states formed significant covalent metal-support interactions (CMSIs), thus providing the ultra-stability and remarkable catalytic performance. This work may provide insights and a new avenue for fabricating supported Au catalysts with ultra-high stability. | Botao Qiao Jin-Xia Liang Aiqin Wang Cong-Qiao Xu Jun Li Tao Zhang Jingyue (Jimmy) Liu | 2015 | Nano Research2015，8，9： | 30 |
| 5 | CMIP6 Evaluation and Projection of Temperature and Precipitation over China显示文摘This article evaluates the performance of 20 Coupled Model Intercomparison Project phase 6(CMIP6)models in simulating temperature and precipitation over China through comparisons with gridded observation data for the period of 1995–2014,with a focus on spatial patterns and interannual variability.The evaluations show that the CMIP6 models perform well in reproducing the climatological spatial distribution of temperature and precipitation,with better performance for temperature than for precipitation.Their interannual variability can also be reasonably captured by most models,however,poor performance is noted regarding the interannual variability of winter precipitation.Based on the comprehensive performance for the above two factors,the“highest-ranked”models are selected as an ensemble(BMME).The BMME outperforms the ensemble of all models(AMME)in simulating annual and winter temperature and precipitation,particularly for those subregions with complex terrain but it shows little improvement for summer temperature and precipitation.The AMME and BMME projections indicate annual increases for both temperature and precipitation across China by the end of the 21st century,with larger increases under the scenario of the Shared Socioeconomic Pathway 5/Representative Concentration Pathway 8.5(SSP585)than under scenario of the Shared Socioeconomic Pathway 2/Representative Concentration Pathway 4.5(SSP245).The greatest increases of annual temperature are projected for higher latitudes and higher elevations and the largest percentage-based increases in annual precipitation are projected to occur in northern and western China,especially under SSP585.However,the BMME,which generally performs better in these regions,projects lower changes in annual temperature and larger variations in annual precipitation when compared to the AMME projections. | Xiaoling YANG Botao ZHOU Ying XU Zhenyu HAN | 2021 | Advances in Atmospheric Sciences2021，38，5： | 21 |
| 6 | MicroRNA expression profiling in diabetic GK rat model显示文摘MicroRNAs (miRNAs ) 是小搁浅单人赛的非编码的 RNA 的一个最新识别的班,经由 post-transcriptional 调整他们的目标基因小径。miRNAs 在许多生物过程起重要作用,这被证明了。为了更好理解 miRNA,在类型 2 糖尿病上工作,我们使用了 oligonucleotide microarray 监视 GotoKakizaki (GK ) 和 Wistar 老鼠的骨胳的肌肉的 miRNA 表达式侧面。七 miRNAs 是下面表示的,二 miRNAs 在 GK 老鼠的肌肉是过去表示的,这被发现。在他们之中, miR-24 显示出最突出的变化。p38 MAPK,是 miR-24 的一个直接目标,也显示出表示差别。所有数据给 miR-24 可能通过 p38 MAPK 的下面规定与糖尿病被联系的线索。 | Bing Huang Wenming Qin Botao Zhao Yi Shi Chengguo Yao Jin Li Huasheng Xiao Youxin Jin | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 17 |
| 7 | Assessment of Indices of Temperature Extremes Simulated by Multiple CMIP5 Models over China显示文摘Given that climate extremes in China might have serious regional and global consequences, an increasing number of studies are examining temperature extremes in China using the Coupled Model Intercomparison Project Phase 5(CMIP5)models. This paper investigates recent changes in temperature extremes in China using 25 state-of-the-art global climate models participating in CMIP5. Thirteen indices that represent extreme temperature events were chosen and derived by daily maximum and minimum temperatures, including those representing the intensity(absolute indices and threshold indices),duration(duration indices), and frequency(percentile indices) of extreme temperature. The overall performance of each model is summarized by a 'portrait' diagram based on relative root-mean-square error, which is the RMSE relative to the median RMSE of all models, revealing the multi-model ensemble simulation to be better than individual model for most indices. Compared with observations, the models are able to capture the main features of the spatial distribution of extreme temperature during 1986–2005. Overall, the CMIP5 models are able to depict the observed indices well, and the spatial structure of the ensemble result is better for threshold indices than frequency indices. The spread amongst the CMIP5 models in different subregions for intensity indices is small and the median CMIP5 is close to observations; however, for the duration and frequency indices there can be wide disagreement regarding the change between models and observations in some regions.The model ensemble also performs well in reproducing the observational trend of temperature extremes. All absolute indices increase over China during 1961–2005. | DONG Siyan XU Ying ZHOU Botao SHI Ying | 2015 | Advances in Atmospheric Sciences2015，32，8： | 16 |
| 8 | Inverse correlation between ancient winter and summer monsoons in East Asia?显示文摘There is a scientific debate on the relationship between ancient winter and summer monsoons in East Asia.Some scholars think that East Asian winter and summer monsoons are anti-correlated,and others think not.For this reason,this study is motivated to assess their linkage from the paleoclimate simulation perspective,through analyzing the Last Glacial Maximum(LGM) and mid-Holocene(MH) climate simulated by CCSM3 model.Compared to the present climate,the Aleutian low is found to be deepened and the East Asian winter monsoon(EAWM) is stronger during the LGM winter.The Pacific high in summer is noticed to be weakened and the East Asian summer monsoon(EASM) is weaker at the LGM.During the MH,the Aleutian low and the Asian high in winter are intensified,and the Asian low and the Pacific high in summer are enhanced,indicating that the EAWM and EASM are both stronger than today.Therefore,the EAWM is not always negatively correlated to the EASM.Their relationship may be different at different geological stages.It can be obtained at least from the numerical simulation results that the EAWM and the EASM is negatively correlated during the cooling period,while positively correlated during the warming period. | ZHOU BoTao ZHAO Ping | 2009 | Chinese Science Bulletin2009，54，20： | 15 |
| 9 | Linkage between winter sea surface temperature east of Australia and summer precipitation in the Yangtze River valley and a possible physical mechanism显示文摘The relationship between winter sea surface temperature (SST) east of Australia and summer precipitation in the Yangtze River valley and a possibly related physical mechanism were investigated using observation data.It is found that winter SST east of Australia is correlated positively to summer precipitation in the Yangtze River valley.When the SST east of Australia becomes warmer in winter,the western Pacific subtropical high and the East Asian westerly jet tend to shift southward the following summer,concurrent with low-level southwesterly anomalies over eastern China.These conditions favor precipitation increase in the Yangtze River valley,whereas the opposite conditions favor precipitation decrease.The influence of winter SST east of Australia on East Asian summer atmospheric circulations may occur in two ways.First,by an anomalous SST signal east of Australia in winter that persists through the following summer,thus affecting East Asian atmospheric circulations via the inter-hemispheric teleconnection.Second,when the SST east of Australia is warmer in winter,higher SST appears simultaneously in the southwest Indian Ocean and subsequently develops eastward by local air-sea interaction.As a result,the SST in the Maritime Continent increases in summer,which may lead to an anomalous change in East Asian summer atmospheric circulations through its impact on convection. | ZHOU BoTao | 2011 | Chinese Science Bulletin2011，56，17： | 12 |
| 10 | Zircon U–Pb and Hf isotopic study of Neoproterozoic granitic gneisses from the Alatage area, Xinjiang:constraints on the Precambrian crustal evolution in the Central Tianshan Block显示文摘The architecture and growth history of Precambrian crustal basements in the Central Tianshan Block play a key role in understanding the tectonic evolution of the Chinese Tianshan Orogenic Belt.In this study,we present precise LA-ICP-MS zircon U–Pb dating and LAMC-ICPMS zircon Hf isotopic data for two granitic gneisses from Alatage area in the Central Tianshan Block.The magmatic zircons from both samples yield similar protolith ages of 945±6 and 942±6 Ma,indicating that the early Neoproterozoic magmatism is prevailed in the Alatage area.These zircons have crustal Hf model ages of1.82–2.22 and 1.70–2.03 Ga,respectively,which are significantly older than their crystallization ages.It indicates that their parental magmas were derived from the reworking of ancient crust.However,we suggest that these Paleoproterozoic Hf model ages might result from mixing of continental materials with different ages in the Neoproterozoic crust.The inherited(detrital)zircon cores not only yield a wide age range of ca.989–1617 Ma,but also exhibit large Hf-isotope variations with Hf model ages of1.54–2.30 Ga.In particular,some 1.4–1.6 Ga zircons show high initial176Hf/177Hf ratios,consistent with those of depleted mantle,which indicates that the Mesoproterozoic event involved both reworking of older crust and generation of juvenile crust.The Central Tianshan Block has different Precambrian crustal growth history from the Tarim Craton.Therefore,it would not be a fragment of the Precambrian basement of the Tarim Craton. | Botao Huang Zhenyu He Keqing Zong Zeming Zhang | 2014 | Chinese Science Bulletin2014，59，1： | 12 |
| 11 | Interdecadal change of the linkage between the North Atlantic Oscillation and the tropical cyclone frequency over the western North Pacific显示文摘The relationship between the North Atlantic Oscillation(NAO) and the tropical cyclone frequency over the western North Pacific(WNPTCF) in summer is investigated by use of observation data. It is found that their linkage appears to have an interdecadal change from weak connection to strong connection. During the period of 1948–1977, the NAO was insignificantly correlated to the WNPTCF. However, during the period of 1980–2009, they were significantly correlated with stronger(weaker) NAO corresponding to more(fewer) tropical cyclones in the western North Pacific. The possible reason for such a different relationship between the NAO and the WNPTCF during the former and latter periods is further analyzed from the perspective of large-scale atmospheric circulations. When the NAO was stronger than normal in the latter period, an anomalous cyclonic circulation prevailed in the lower troposphere of the western North Pacific and the monsoon trough was intensified, concurrent with the eastward-shifting western Pacific subtropical high as well as anomalous low-level convergence and high-level divergence over the western North Pacific. These conditions favor the genesis and development of tropical cyclones, and thus more tropical cyclones appeared over the western North Pacific. In contrast, in the former period, the impact of the NAO on the aforementioned atmospheric circulations became insignificant, thereby weakening its linkage to the WNPTCF. Further study shows that the change of the wave activity flux associated with the NAO during the former and latter periods may account for such an interdecadal shift of the NAO–WNPTCF relationship. | ZHOU BoTao CUI Xuan | 2014 | Science China Earth Sciences2014，57，9： | 11 |
| 12 | Sea surface temperature east of Australia:A predictor of tropical cyclone frequency over the western North Pacific?显示文摘The relationship between sea surface temperature (SST) east of Australia and tropical cyclone frequency over the western North Pacific (WNPTCF) is analyzed by use of observation data.The WNPTCF from June to October is correlated negatively to spring SST east of Australia.When the spring SST is in the positive phase,a cyclonic circulation anomaly in the upper troposphere and an anticyclonic circulation anomaly in the lower troposphere prevail over the western North Pacific from June to October,concurrent with an anomalous atmospheric subsidence and an enlarged vertical zonal wind shear.These conditions are unfavorable for tropical cyclone genesis,and thus WNPTCF decreases.The negative phase of the spring SST east of Australia leads to more tropical cyclones over the western North Pacific.The spring SST east of Australia may give rise to simultaneous change in tropical atmospheric circulation via the teleconnection wave train,and then subsequently affect atmospheric circulation variation over the western North Pacific. | ZHOU BoTao 1,2 & CUI Xuan 3 1 National Climate Center,China Meteorological Administration,Beijing 100081,China 2 Nansen-Zhu International Research Center,Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing 100029,China 3 National Meteorological Center,China Meteorological Administration,Beijing 100081,China | 2011 | Chinese Science Bulletin2011，56，2： | 11 |
| 13 | Projected Changes in Temperature and Precipitation Extremes over China as Measured by 50-yr Return Values and Periods Based on a CMIP5 Ensemble显示文摘Future changes in the 50-yr return level for temperature and precipitation extremes over China's Mainland are investigated based on a CMIP5 multi-model ensemble for RCP2.6, RCP4.5 and RCP8.5 scenarios. The following indices are analyzed:TXx and TNn(the annual maximum and minimum of daily maximum and minimum surface temperature), RX5 day(the annual maximum consecutive 5-day precipitation) and CDD(maximum annual number of consecutive dry days). After first validating the model performance, future changes in the 50-yr return values and return periods for these indices are investigated along with the inter-model spread. Multi-model median changes show an increase in the 50-yr return values of TXx and a decrease for TNn, more specifically, by the end of the 21 st century under RCP8.5, the present day 50-yr return period of warm events is reduced to 1.2 yr, while extreme cold events over the country are projected to essentially disappear.A general increase in RX5 day 50-yr return values is found in the future. By the end of the 21 st century under RCP8.5, events of the present RX5 day 50-yr return period are projected to reduce to < 10 yr over most of China. Changes in CDD-50 show a dipole pattern over China, with a decrease in the values and longer return periods in the north, and vice versa in the south. Our study also highlights the need for further improvements in the representation of extreme events in climate models to assess the future risks and engineering design related to large-scale infrastructure in China. | Ying XU Xuejie GAO Filippo GIORGI Botao ZHOU Ying SHI Jie WU Yongxiang ZHANG | 2018 | Advances in Atmospheric Sciences2018，35，4： | 11 |
| 14 | Typhoon disaster zoning and prevention criteria——A double layer nested multi-objective probability model and its application显示文摘For prevention and mitigation of typhoon disasters in China, in this paper a double layer nested multi-objective probability model of typhoon disaster zoning and prevention criteria is proposed. The multivariate compound extreme value distribution (MCEVD) is used to predict the joint probability of seven typhoon characteristics and corresponding typhoon induced disasters. Predicted results can be used for both typhoon disaster zoning and corresponding prevention criteria along China coast. | LIU DeFu PANG Liang XIE BoTao WU YuanKang | 2008 | Science China(Technological Sciences)2008，51，7： | 10 |
| 15 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 16 | Integrating Local Binary Patterns into Normalized Moment of Inertia for Updating Tracking Templates显示文摘This paper presents an efficient visual tracking framework which is robust to rotation,scale variation and occlusion.The target template is characterized by Local binary patterns(LBP),which exhibit invariance to rotation.The LBP features are then integrated into the Normalized moment of inertia(NMI) to decide whether the template requires update.This procedure enables an adaptive template matching strategy which addresses the tracking failures arising from scale variations.Kalman filtering is exploited for predicting the tra jectory of the target when it is occluded.The matching efficiency is achieved by applying a locally pyramid searching scheme.Experimental results validate the efficiency and effectiveness of our tracking framework. | SONG Huajun XIAO Botao HU Qinzhen REN Peng | 2016 | Chinese Journal of Electronics2016，25，4： | 8 |
| 17 | Status quo and development trend of lost foam casting technology显示文摘Lost foam casting(LFC)technology has been widely applied to cast iron and cast steel.However,the development of LFC for Al and Mg alloys was relatively slower than that for cast iron and cast steel.The application of LFC to Al and Mg alloys needs more effort,especially in China.In this paper,the development history of LFC is reviewed,and the application situations of LFC to Al and Mg alloys are mainly discussed.Meanwhile,the key problems of LFC for Al and Mg alloys are also pointed out.Finally,the prospects for LFC technology are discussed,and some special new LFC technologies are introduced for casting Al and Mg alloys.In future,the development trends of green LFC technology mainly focus on the special new LFC methods,metal material,coating,heat treatment,new foam materials as well as purification technology of tail gas,etc. | Fan Zitian Jiang Wenming Liu Fuchu Xiao Botao | 2014 | China Foundry2014，11，4： | 6 |
| 18 | Atomic Co/Ni dual sites with N/P-coordination as bifunctional oxygen electrocatalyst for rechargeable zinc-air batteries显示文摘Metal-nitrogen-carbon(M-N-C)single-atom catalysts exhibit desirable electrochemical catalytic properties.However,the replacement of N atoms by heteroatoms(B,P,S,etc.)has been regarded as a useful method for regulating the coordination environment.The structure engineered M-N-C sites via doping heteroatoms play an important role to the adsorption and activation of the oxygen intermediate.Herein,we develop an efficient strategy to construct dual atomic site catalysts via the formation of a Co_(1)-PN and Ni1-PN planar configuration.The developed Co_(1)-PNC/Ni1-PNC catalyst exhibits excellent bifunctional electrocatalytic performance in alkaline solution.Both experimental and theoretical results demonstrated that the N/P coordinated Co/Ni sites moderately reduced the binding interaction of oxygen intermediates.The Co_(1)-PNC/Ni1-PNC endows a rechargeable Zn-air battery with excellent power density and cycling stability as an air-cathode,which is superior to that of the benchmark Pt/C+IrO_(2).This work paves an avenue for design of dual single-atomic sites and regulation of the atomic configuration on carbon-based materials to achieve high-performance electrocatalysts. | Botao Hu Aijian Huang Xuejiang Zhang Zheng Chen Renyong Tu Wei Zhu Zhongbin Zhuang Chen Chen Qing Peng Yadong Li | 2021 | Nano Research2021，14，10： | 6 |
| 19 | BMPRII is a direct target of miR-21显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 阶段调整血缘的 mRNA 表情的小非编码的 RNA 的一种类型。尽管几 miRNAs 被知道涉及各种各样的生物进程,包括发展预定, patterning, embryogenesis,区别和 organogenesis,生长控制,和 apoptosis,许多目标基因和大多数 miRNAs 的函数仍然是不清楚的。因为仅仅在动物房间在 miRNAs 和他们的目标之间有部分补充,为给定的 miRNA 识别特定的目标基因并且阐明是困难的它的功能。在这研究,我们证实了形态基因的蛋白质受体 II (BMPRII ) 是的那根骨头 miR-21 的一个直接目标,并且也证明 BMPRII 的蛋白质水平在 PC3 和 Lncap 房间与 miR-21 的数量相反地相关。这些调查结果建议 miR-21 可以在由调整 BMPRII 的表示调整恶意和前列腺癌症房间并且在干细胞的自强的变形能力有一个潜在的角色。 | Wenming Qin Botao Zhao Yi Shi Chengguo Yao Li Jin Youxin Jin | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 5 |
| 20 | MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells显示文摘MicroRNAs (或 miRNAs ) 是涉及与房间的发展和区别有关的大量活动的小非编码的 RNA (2125 核苷酸) 。区分的神经干细胞的有那些的鼠标 P19 胚胎的癌房间的 miRNA 表达式侧面的比较证明表达式在区别以后 65 铺平改变的 miRNAs (2 褶层) 。MiR-124a 是戏剧性地起来调整的(超过 20 褶层) 当在 miR-290295 簇的 miR-302 家庭和那些的 miRNAs 是强烈下面调整的时。进一步的分析表明象 Oct4 和 Sox2 那样的一些重要因素看起来涉及这些 miRNAs 的规定。这些结果可以在早老鼠胚胎贡献调整 miRNA 的神经区别的更好的理解。 | Bing Huang Wei Li Botao Zhao Caihong Xia Ruqiang Liang Kangcheng Ruan Naihe Jing Youxin Jin | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 5 |
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