|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | TMT激光导引星系统设计显示文摘激光导引星系统(LGSF)是美国30 m望远镜(TMT)的组成部分之一,在满足TMT对科学目标高分辨力成像和光谱探测的性能需求方面,LGSF具有重要的作用。LGSF主要负责为窄视场红外自适应光学系统(NFIRAOS)和下一代TMT-AO系统提供人造钠导星。本文主要讨论LGSF以下几部分:设计概述,LGSF星群模式,LGSF波前误差分配,发射系统设计。 | 李敏 江长春 魏凯 凡木文 芮道满 唐金龙 Boyer C Wang L Q Trubey M | 2018 | 光电工程2018，45，3： | 2 |
| 3 | Benard-von Karman instability: transient and forced regimes显示文摘 | Provansal M Mathis C Boyer L | 1987 | J Fluid Mech1987，182，： | 2 |
| 4 | A rapid,sensitive method for the quantitation of specific metabolites of sulfur mustard in human urine using isotope-dilution gas chromatography-tandem mass spectrometry显示文摘 | YOUNG C L ASH D DRISKELL W J BOYER A E MARTINEZ R A SILKS L A BARR J R | 2004 | Anal Toxicol2004，28，5： | 1 |
| 5 | Transplanted BM and BM side population cells contribute progeny to the lung and liver in irradiated mice 显示文摘 | Abe S Lauby G Boyer C | 2003 | Cytotherapy2003，，5： | 1 |
| 6 | Dorsal locked plate fixation of dis?tal radius fractures显示文摘 | Lutsky K Boyer M Goldfarb C | 2013 | J Hand Surg Am2013，38，7： | 1 |
| 7 | Construction of biologically functional bacterial plasmids in vitro显示文摘 | Cohen S N Chang A C Y Boyer H W | 1973 | Proe Natl Acad Sci USA1973，70，11： | 1 |
| 8 | Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells显示文摘 | BOYER J C CAMPBELL C E SIGURDSON W J | 2005 | Biochem Biophys Res Commun2005，334，1： | 1 |
| 9 | Construction of biologically functional bacterial in vitro 显示文摘 | Cohen S N Chang A C Y Boyer H W | 1973 | Proceedings of the National Academy of Sciences of the United States of America1973，70，： | 1 |
| 10 | Retinal thickness measurements from optical coherence tomography using a markov boundary model显示文摘 | Koozekanani D Boyer K Roberts C | 2001 | IEEE transaction on medical imaging2001，20，9： | 1 |
| 11 | Heat - induced gelation of myofibrillar proteins and myosin from fast - and slow- twitch rabbit muscles 显示文摘 | Boyer C Joandel V Roussilhes V | 1996 | J Food Sci1996，61，6： | 1 |
| 12 | Minireview: Infectious transcripts and cDNA clone of RNA viruses 显示文摘 | Boyer J C Haenni A L | 1994 | Virology1994，185，： | 1 |
| 13 | Construction of biologically functional bacterial plasmid in vitro, 1973 显示文摘 | Cohen S N Chang A C Boyer H W | 1992 | Biotechnology1992，24，： | 1 |
| 14 | Carbohydrate composition and sensory quality of fresh and stored sweet corn 显示文摘 | Evensen K B C O Boyer | 1986 | Journal of the American Society for Horticuhural Science1986，111，： | 1 |
| 15 | Bench-scale testing of a magnetic ion exchange resin for removal of disinfection by-product precursors 显示文摘 | Boyer T H Singer P C | 2005 | Water Res2005，39，7： | 1 |
| 16 | Exploratory spatial data analysis of regional seroprevalence of antibodies against epizootic hemorrhagic disease virus in cattle from Illinois and Indiana 显示文摘 | BOYER T C WARD M P WALLACE R L | 2008 | American Journal of Veterinary Research2008，69，： | 1 |
| 17 | Genetic diversity in the coat protein coding region of eighty-aix sugarcane mosaic virus isolates from eight countries particularly from Cameroon and Congo显示文摘 | Alegria O M Boyer M Bousalem M Chatenet M Pterschnfitt M Girard J C Rott P | 2003 | Archives of Virology2003，148，： | 1 |
| 18 | Color encoded structured light for rapid active ranging 显示文摘 | Boyer K L Kak A C | 1987 | IEEE Trans on PAMI-91987，9，1： | 1 |
| 19 | Analysis for partially penetrating sand drains显示文摘 | HART E G KONDNER R L BOYER W C | 1958 | Journal of Soil Mechanics and Foundation Division Proceedings of ASCE1958，1812，： | 1 |
| 20 | Biogeochemical hot spots and hot moments at the interface of terrestrial and aquatic ecosystems 显示文摘 | MCCLAIN M E BOYER E W DENT C I | 2003 | Ecosystem2003，6，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员