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		题名	作者	年代	出处	被引量
	1	HIF-1α与VEGF及MVD在食管鳞癌组织中的表达及意义(英文)显示文摘Objective:To investigate the correlations among the expressions of hypoxia-inducible factor-1α(HIF-1α),vas-cular endothelial cell growth factor(VEGF) and microvessel density(MVD),and their relationships to the clinicopathologic characteristics of esophageal squamous cell carcinomas(ESCC).Methods:The expressions of HIF-1α,VEGF and MVD were detected by immunohistochemical method in 45 cases of ESCC,30 intraepithelial neoplasia and 35 normal esophageal mucosal epithelia tissues.The correlations among the expressions of HIF-1a,VEGF and MVD,and their relationships to the clinicopathologic features of ESCC were analyzed.Results:The rate of positive expression of HIF-1α and VEGF which were 80% and 84% in ESCC were significantly higher than those in intraepithelial neoplasia and normal esophageal mucosal epi-thelium tissues (P < 0.01) and so did the MVD value which was 71.10 ± 15.02 in ESCC(P < 0.01).The expression of HIF-1α and VEGF were positively correlated with the depth of tumor invasion,lymph node metastasis and TNM staging of ESCC.The expressions of HIF-1α were positively correlated with the expressions of VEGF and the value of MVD.Conclusion:Overexpression of HIF-1α is found in ESCC.HIF-1α may induce the angiogenesis in ESCC by upregulating the transcription of VEGF gene.It may play an important role in the carcinogenesis and aggression in ESCC,HIF-1α,VEGF and MVD may be a useful marker for evaluating the biological behaviors of ESCC.	Feng Liu Xiaolong Yang Boying Ding Gang Ren Rongfu Gong	2009	The Chinese-German Journal of Clinical Oncology2009，8，4：	2

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