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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Effect of feed deprivation and lairage time on carcass and meat quality traits on pigs under minimal stressful conditions显示文摘 | Panella-Riera N Gispert M Gil M Soler J Tibau J Oliver M A Velarde A Fàbrega E | | 0，，01： | 1 |
| 3 | Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies显示文摘 | Fi~bregas N Ewig S Tortes A | 1999 | Thorax1999，54，10： | 1 |
| 4 | Exclusively endoscopic surgery for juvenile nasopharyngeal angiofibroma显示文摘 | ANDRADE N A PINTO J A NBREGA M O | 2007 | Otolaryngol Head Neck Surg2007，137，： | 1 |
| 5 | Surface and gas phase temperatures of a tungsten coil atomizer显示文摘 | Queiroz Z F Oliveira P V Nóbrega J A | 2002 | Spectrochim Acta Part B2002，57，11： | 1 |
| 6 | Transcutaneous electricalstimulation for pain relief during labor:a systematic review andmeta-analysis显示文摘 | Mello L F Nóbrega L F Lemos A | 2011 | Rev Bras Fisioter2011，15，3： | 1 |
| 7 | Two-stage cultures for the production of Astaxanthin from Haematococcus pluvialis显示文摘 | Fa'bregas J Otero A Maseda A | 2001 | Journal of Biotechnology2001，89，： | 1 |
| 8 | Extraconnectivity of graphs with large girth显示文摘 | Fábrega J Fiol M A | 1994 | Discrete Math1994，127，： | 1 |
| 9 | Mechanisms underlying the relationship between health literacy and glycemic control in American Indians and Alaska natives 显示文摘 | Brega A G Ang A Vega W | 2012 | Patient Educ Couns2012，88，1： | 1 |
| 10 | Optimization of culture medium for the continuous cultivation of the microalga Haematococcus pluvialis显示文摘 | Fábregas J Dominguez A Regueiro M | 2000 | Appl Microbiol Biotechnol2000，53，： | 1 |
| 11 | Ultrastructural definition of apop- tosis in heart failure 显示文摘 | Arbustini E Brega A Narula J el al | 2005 | Heart Fail Rev2005，13，： | 1 |
| 12 | Yersinia enterocolitica: Pathogenesis, virulence and antimicrobial resistance显示文摘 | Fàbrega A Vila J | 2012 | Enferm Infecc Microbiol Clin2012，30，1： | 1 |
| 13 | Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage显示文摘 | Martí-fàbregas Joan Delgado-mederos Raquel Granell Esther Morenas Rodríguez Estrella Marín Lahoz Juan Dinia Lavinia Carrera David Pérez De La Ossa Natalia Sanahuja Jordi Sobrino Tomás De Arce Ana María Alonso De Leci?ana María | 2013 | European Neurology . 2013 (3-4)2013，，3： | 1 |
| 14 | Ultrastructural definition of apoptosis in heart failure显示文摘 | Arbustini E Brega A Narula J | 2008 | Heart Fail Rev2008，13，： | 1 |
| 15 | Comparison of decomposition procedures for analysis of titanium dioxide using inductively coupled plasma optical emission spectrometry显示文摘 | Maria das Gra?as A Korn Adriana C Ferreira Ant?nio C.S Costa Joaquim A Nóbrega Claudinéia R Silva | 2002 | Microchemical Journal2002，，1： | 1 |
| 16 | Plasma Leptin and TNF-α Levels in Chronic Hepatitis C Patients and Their Relationship to Hepatic Fibrosis显示文摘 | Javier Crespo Montserrat Rivero Emilio Fábrega Amalía Cayón José Antonio Amado Maria Teresa García-Unzeta Fernando Pons-Romero | 2002 | Digestive Diseases and Sciences2002，，7： | 1 |
| 17 | Performance analysis of turbo-coded APSK modulations over nonlinear satellite channels显示文摘 | De Gaudenzi R Guillén i Fàbregas A | 2006 | IEEE Transactions on Wireless Communications2006，5，9： | 1 |
| 18 | The role of molecular pathology in non-small-cell lung carcinoma-now and in the future 显示文摘 | Brandao GD Brega EF Spatz A | 2012 | Curr Oncol2012，19，1： | 1 |
| 19 | Analysis of soliton switching in dispersion-decreasing fiber couplers显示文摘 | K Z No′brega A S B Sombra | 1999 | Optics Communications1999，171，： | 1 |
| 20 | Interactions between irradiance and nutrient availability during astaxanthin accumulation and degradation in Haematococcus pluvialis显示文摘 | Fábregas J Dominguez A Maseda A Otero A | 2003 | Applied Microbiology and Biotechnology2003，61，56： | 1 |
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