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5篇 您的检索式：作者名="Brenda Nguyen"

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		题名	作者	年代	出处	被引量
	1	IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。	Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright	2018	Cellular & Molecular Immunology2018，15，5：	17
	2	Allogeneic Hematopoietic Cell Transplantation for Chronic Myelomonocytic Leukemia: Relapse-Free Survival Is Determined by Karyotype and Comorbidities显示文摘	Hesham Eissa Ted A. Gooley Mohamed L. Sorror Franchesca Nguyen Bart L. Scott Kristine Doney Keith R. Loeb Paul J. Martin John M. Pagel Jerry P. Radich Brenda M. Sandmaier E. Houston Warren Rainer Storb Frederick R. Appelbaum H. Joachim Deeg	2011	Biology of Blood and Marrow Transplantation2011，，：	2
	3	Rationale for the combination of cryoablation with surgical resection of hepatic tumors显示文摘	Charles Cha M.D. Fred T. Lee M.D. Layton F. Rikkers M.D. John E. Niederhuber M.D. Brenda T. Nguyen M.D. David M. Mahvi M.D	2001	Journal of Gastrointestinal Surgery2001，，2：	1
	4	Rationale for the combination of cryoablation with surgical resection of hepatic tumors显示文摘	Charles Cha M.D. Fred T. Lee M.D. Layton F. Rikkers M.D. John E. Niederhuber M.D. Brenda T. Nguyen M.D. David M. Mahvi M.D	2001	Journal of Gastrointestinal Surgery2001，，2：	1
	5	Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse显示文摘	Brenda J. Polster Shawn K. Westaway Thuy M. Nguyen Moon Y. Yoon Susan J. Hayflick	2010	Molecular Genetics and Metabolism2010，，：	1

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