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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infaretion显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 3 | Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events:more than simply a marker of glomerular filtration rate显示文摘 | Koeni W Twardella D Brenner H | 2005 | Clin Chem2005，51，2： | 1 |
| 4 | Severity and extent of os-teoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein显示文摘 | STURMER T BRENNER H AKOENIG W | 2004 | Ann Rheum Dis2004，63，： | 1 |
| 5 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M Dersimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 6 | Cell therapy anenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，14： | 1 |
| 7 | Symbolic kinship program显示文摘 | Brenner C H | 1997 | Genetics1997，145，： | 1 |
| 8 | Comparison of N - terminal pro- B - natriuretic peptide, C - reactive protein, and creatinine clearance for prognosis in patients with known coronary heart disease 显示文摘 | Rothenbacher D Koenig W Brenner H | 2006 | Arch Intern Med2006，166，22： | 1 |
| 9 | Role of colonoscopy and polyp characteristics in colorectal cancer after colonoscopic polyp detection:a population-based case-control study显示文摘 | Brenner H Chang-Claude J Jansen L | 2012 | Ann Intern Med2012，157，4： | 1 |
| 10 | Involvement of abscisic acid in potato cold acclimation 显示文摘 | CHEN H H LIP H BRENNER M L | 1983 | Plant Physiol1983，71，1： | 1 |
| 11 | Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21 st century 显示文摘 | Puhe D Gondos A Brenner H | 2009 | Blood2009，113，7： | 1 |
| 12 | Solar Forcing of Drought Frequency in the Maya Lowlands 显示文摘 | David A Hodell Mark Brenner Jason H Curtis | 2001 | SCIENCE2001，292，18： | 1 |
| 13 | Small bowel obstruction caused by secondary tumors显示文摘 | Idelevich E Kashtan H Mayor E Brenner B | 2006 | Surg Oncol2006，15，1： | 1 |
| 14 | Plasma concentra- tions of cystatin C in patients with coroary heart disease and risk for secondary cardiovascular events, more than simply a marker of glomerular filtration rate显示文摘 | KoeniW Twardella D Brenner H | 2005 | Clin Chem2005，51，2： | 1 |
| 15 | Epidemiology ofstomach cancer显示文摘 | Brenner H Rothenbacher D Arndt V | 2009 | Methods Mol Biol2009，472，23： | 1 |
| 16 | Effect of alchol con- sumption on systemic markers of inflammation显示文摘 | Imhof A Froehlich M Brenner H | 2001 | Lancet2001，357，： | 1 |
| 17 | BK channel 134 subunit reduces dentate gyrus excitability and protects a- gainst temporal lobe seizures显示文摘 | Brenner R Chen Q H Vilaythong A | 2005 | Nat Neurosei2005，8，12： | 1 |
| 18 | DNA commission of the International Society of Forensic Genetics:Recommendations on the interpretation of mixtures显示文摘 | Gill P Brenner C H Buckleton J S | | 0，，： | 1 |
| 19 | Controlling for continuous confounders in epidemiologic research 显示文摘 | Brenner H Blettner M | 1997 | Epidemiology1997，8，4： | 1 |
| 20 | Plasma concentrations of Cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate显示文摘 | KeoniW Twardella D Brenner H | 2005 | Clin Chem2005，51，2： | 1 |
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