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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | Electrospun poly(vinylidene fluoride-trifluoroethylene)/ zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation显示文摘响应机械紧张产生电的信号的压电的材料能在设计刺激房间增长的织物被使用。Poly (vinylidene fluoride-trifluoroethylene )(P (VDF-TrFE )) ,压电的聚合物,广泛地在 biomaterial 应用被使用。我们假设了进 P (VDF-TrFE ) 矩阵的 nanoparticles 能支持的锌氧化物(ZnO ) 的那加入房间的粘附,移植,和增长,以及血容器形成(angiogenesis ) 。在这研究,我们制作了并且包括地描绘了新奇 electrospun P (VDF-TrFE )/ZnO nanocomposite 织物设计支架。我们由扫描电子显微镜学分析了聚合矩阵的词法特征,并且利用了红外线的光谱学, X 光检查衍射,和检验的微分扫描热量测定由于 nanoparticles 的增加在共聚物的水晶的阶段改变的 Fourier 变换。我们不检测了,显示 P (VDF-TrFE )/ZnO nanocomposite 脚手架对设计应用的织物合适或关于在 vitro, biocompatibility,和 cytotoxicity 的血相容性的 biomaterials 的最小的不利效果。有趣地,人的间充质的干细胞(hMSCs ) 和在 nanocomposite 脚手架上有教养的人的脐的静脉 endothelial 房间与在织物文化盘子或整洁的 P (VDF-TrFE ) 上有教养的房间相比展出了更高的房间生存能力,粘附,和增长脚手架。植入进老鼠与或没有 hMSCs 的 Nanocomposite 脚手架没得到免疫学的回答,由宏观的分析和组织学估计了。重要地, nanocomposite 脚手架支持了 angiogenesis,它在脚手架被增加与 hMSCs 预先播种。总的来说,我们的结果在织物工程为使用加亮这些新奇 P (VDF-TrFE )/ZnO nanocomposites 的潜力,由于他们支持房间粘附和 angiogenesis 的 biocompatibility 和能力。 | Robin Augustine Pan Dan Alejandro Sosnik Nandakumar Kalarikkal Nguyen Tran Brice Vincent Sabu Thomas Patrick Menu Didier Rouxel | 2017 | Nano Research2017，10，10： | 8 |
| 3 | 男性择偶策略改变的前提:自感配偶价值提高(英文)显示文摘研究分为问卷调查与实验研究两部分。首先,40名女性和33名男性完成有关自感配偶价值评价(SPMV)和择偶偏爱策略的问卷调查,问卷调查结果是实验研究中数据分析的基线。其次,第二部分实验开始后,被试会得到实验者编造的他人潜在择偶对象的积极正面评价,其目的在于提高被试的SPMV。可以假设,男性的 SPMV 与随意性行为的认同或追求有正相关,男性 SPMV 的提高将会更加偏爱短期的性策略;女性 SPMV 与随意性行为不存在相关,女性 SPMV 的提高不会改变女性的性策略。研究结果显示,SPMV 高基线水平的男性更加认可随意性行为,男性 SPMV 的提高与短期策略选择的增加有关。另外,SPMV 提高,而不是一般自尊的提高,与择偶策略的改变具有相关。本研究结果没有证实,与长期稳定的性关系相比,SPMV 的基线水平或是提高与女性对随意性行为的认同或追求之间存在相关。 | Michele. K. Surbey Gavin. R. Brice | 2007 | 心理学报2007，39，3： | 8 |
| 4 | Looking Back and Beyond Sendai:25 Years of International Policy Experience on Disaster Risk Reduction显示文摘The evolution in knowledge and application of disaster risk reduction in the 25 years of global cooperation on this issue has been uneven. While advances in knowledge have improved our understanding of the full nature of risk—the combination of hazards meeting vulnerability—the application of such knowledge has not been conducive to the development of institutional and technical mechanisms to address the full range of risk elements. Governance of risk(policies, legislation, and organizational arrangements) still focuses largely on preparing to respond to the hazards and planning for recovery. This leaves largely unattended the vulnerability component of risk, which is the only component on which change can be effected.Governance arrangements, risk assessments, early warning systems, and other institutional and technical capacities still concentrate on natural hazards and this is the main change that remains to be substantively addressed. | Sálvano Briceo | 2015 | International Journal of Disaster Risk Science2015，6，1： | 8 |
| 5 | Effect of technical parameters on transjugular intrahepatic portosystemic shunts utilizing stent grafts显示文摘AIM: To assess the effect of technical parameters on outcomes of transjugular intrahepatic portosystemic shunt(TIPS) created using a stent graft.METHODS: The medical records of 68 patients who underwent TIPS placement with a stent graft from 2008 to 2014 were reviewed by two radiologists blinded to the patient outcomes.Digital Subtraction Angiographic images with a measuring catheter in two orthogonal planes was used to determine the TIPS stent-to-inferior vena cava distance(SIVCD),hepatic vein to parenchymal tract angle(HVTA),portal vein to parenchymal tract angle(PVTA),and the accessed portal vein.The length and diameter of the TIPS stent and the use of concurrent variceal embolization were recorded by review of the patient's procedure note.Data on re-intervention within 30 d of TIPS placement,recurrence of symptoms,and survival were collected through the patient's chart.Cox proportional regression analysis was performed to assess the effect of these technical parameters on primary patency of TIPS,time to recurrence of symptoms,and all-cause mortality.RESULTS: There was no significant associationbetween the SIVCD and primary patency(P = 0.23),time to recurrence of symptoms(P = 0.83),or allcause mortality(P = 0.18).The 3,6,and 12-mo primary patency rates for a SIVCD ≥ 1.5 cm were 82.4%,64.7%,and 50.3% compared to 89.3%,83.8%,and 60.6% for a SIVCD of < 1.5 cm(P = 0.29).The median time to stenosis for a SIVCD of ≥ 1.5 cm was 19.1 mo vs 15.1 mo for a SIVCD of < 1.5 cm(P = 0.48).There was no significant association between the following factors and primary patency: HVTA(P = 0.99),PVTA(P = 0.65),accessed portal vein(P = 0.35),TIPS stent diameter(P = 0.93),TIPS stent length(P = 0.48),concurrent variceal embolization(P = 0.13) and reinterventions within 30 d(P = 0.24).Furthermore,there was no correlation between these technical parameters and time to recurrence of symptoms or all-cause mortality.Recurrence of symptoms was associated with stent graft stenosis(P = 0.03).CONCLUSION: TIPS stent-to-caval distance and other parameters have no significant effect on primary patency,time to recurrence of symptoms,or all-cause mortality following TIPS with a stent-graft. | Brice Andring Sanjeeva P Kalva Patrick Sutphin Rajiv Srinivasa Alvin Anene Marc Burrell Yin Xi Anil K Pillai | 2015 | World Journal of Gastroenterology2015，21，26： | 7 |
| 6 | Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression显示文摘BACKGROUND: Proliferation of hepatic stellate cells(HSCs) plays a pivotal role in the progression of liver fibrosis consequent to chronic liver injury. Silibinin, a flavonoid compound,has been shown to possess anti-fibrogenic effects in animal models of liver fibrosis. This was attributed to an inhibition of cell proliferation of activated HSCs. The present study was to gain insight into the molecular pathways involved in silibinin anti-fibrogenic effect. METHODS: The study was conducted on LX-2 human stellate cells treated with three concentrations of silibinin(10, 50 and 100 μmol/L) for 24 and 96 hours. At the end of the treatment cell viability and proliferation were evaluated. Protein expression of p27, p21, p53, Akt and phosphorylated-Akt was evaluated by Western blotting analysis and Ki-67 protein expression was by immunocytochemistry. Sirtuin activity was evaluated by chemiluminescence based assay. RESULTS: Silibinin inhibits LX-2 cell proliferation in doseand time-dependent manner; we showed that silibinin upregulated the protein expressions of p27 and p53. Such regulation was correlated to an inhibition of both downstream Akt and phosphorylated-Akt protein signaling and Ki-67 protein expression. Sirtuin activity also was correlated to silibinininhibited proliferation of LX-2 cells. CONCLUSION: The anti-proliferative effect of silibinin on LX-2 human stellate cells is via the inhibition of the expressions of various cell cycle targets including p27, Akt and sirtuin signaling. | Devaraj Ezhilarasan Jonathan Evraerts Brice Sid Pedro Buc Calderon Sivanesan Karthikeyan Etienne Sokal Mustapha Najimi | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 7 |
| 7 | Phosphorus mobility in dam reservoir affected by redox oscillations:An experimental study显示文摘The internal sedimentary phosphorus(P) load of aquatic systems is able to support eutrophication, especially in dam–reservoir systems where sedimentary P stock is high and where temporary anaerobic conditions occur. The aim of this study therefore is to examine the response of sedimentary P exposed to redox oscillations. Surface sediments collected in the Champsanglard dam–reservoir(on the Creuse River, France) were subjected to two aerobic phases(10 and 12 days) alternated with two anaerobic periods(21 and 27 days)through batch incubations. The studied sediment contained 77 ± 3 μmol/g DW of P, mainly associated with the ascorbate fraction(amorphous Fe/Mn oxyhydroxides). The used sediment was rich in organic matter(OM)(21% ± 1%) with primarily allochthone signature.Our results showed that redox oscillations enhance dissolved inorganic phosphorus release at sediment/water interface. During the first anaerobic stage, the P release was mainly controlled by the dissolution/precipitation of iron minerals. The more pronounced increase of P release during the second anaerobic stage(44%) was due to various mechanisms related to the change in quality of dissolved organic matter(DOM), namely a higher SUVA254 and humification indices. The release of more refractory DOM(rDOM) served to lower the microbial metabolism activity, possibly favored iron oxyhydroxide aggregation and thus limiting iron reduction. In addition, rDOM is able to compete for mineral P sorption sites,leading to a greater P release. In reservoir with predominant allochthone OM input, the release of more aromatic DOM therefore plays an important role in P mobility. | Anne Rapin Malgorzata Grybos Marion Rabiet Brice Mourier Véronique Deluchat | 2019 | Journal of Environmental Sciences2019，31，3： | 6 |
| 8 | Multidisciplinary management of Mirizzi syndrome with cholecystobiliary fistula: the value of minimally invasive endoscopic surgery显示文摘Mirizzi syndrome, a rare complication of gallstones, is defined by obstruction of the main bile duct. This obstruction may worsen and thus result in cholecystobiliary fistula. Surgical management of Mirizzi syndrome is complicated by the presence of inflamed tissue around the hepatic pedicle, making it impossible to distinguish between the main bile duct and the gallbladder. The surgeon's first task is to perform subtotal cholecystotomy(from the fundus of the gallbladder to the neck) without trying to locate the cystic duct. In a second step, the gallstones are extracted and the main bile duct is then repaired. In most cases, a T-tube is used to drain the main bile duct, and abdominal drainage is left in place(in case a bile fistula forms). This study concluded that preoperative drainage of the main bile duct in the treatment of Mirizzi syndrome types II and III is feasible and might help to decrease the postoperative complication rate. | Fabien Le Roux Charles Sabbagh Brice Robert Thierry Yzet Laurent Dugue Jean-Paul Joly Jean-Marc Regimbeau | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 6 |
| 9 | Millikan改良网塞疝修复术显示文摘自1890年Bassini发表腹股沟疝修补术以来,在术式方面有过了多改进.过去20年中,网片修补技术因具减张的优点而被广泛接受.20世纪70年代,Lichtenstein和Shore首先创用网塞治疗股疝和复发性疝[1]:Gilbert随之在80年代用之于治疗斜疝[2]:Rutkow和Robbins在90年代倡用预制的网塞加补片治疗各种腹股沟疝[3,4]. | Keith W.Millikan Brice Cummings Alexander Doolas 王晔鸣 | 2005 | 外科理论与实践2005，10，6： | 6 |
| 10 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 11 | What to Eat:Evidence for Selective Autophagy in Plants显示文摘Autophagy is a macromolecular degradation pathway by which cells recycle their contents as a developmental process,housekeeping mechanism,and response to environmental stress.In plants,autophagy involves the sequestration of cargo to be degraded,transport to the cell vacuole in a double-membrane bound autophagosome,and subsequent degradation by lytic enzymes.Autophagy has generally been considered to be a non-selective mechanism of degradation.However,studies in yeast and animals have found numerous examples of selective autophagy,with cargo including proteins,protein aggregates,and organelles.Recent work has also provided evidence for several types of selective autophagyin plants.The degradation of protein aggregates was the first selective autophagy described in plants,and,more recently,a hybrid protein of the mammalian selective autophagy adaptors p62 and NBR1,which interacts with the autophagy machinery and may function in autophagy of protein aggregates,was described in plants.Other intracellular components have been suggested to be selectively targeted by autophagy in plants,but the current evidence is limited.Here,we discuss recent findings regarding the selective targeting of cell components by autophagy in plants. | Brice E.Floyd Stephanie C.Morriss Gustavo C.MacIntosh Diane C.Bassham | 2012 | Journal of Integrative Plant Biology2012，54，11： | 5 |
| 12 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 13 | The natural history of Ebola virus in Africa显示文摘 | Xavier Pourrut Brice Kumulungui Tatiana Wittmann Ghislain Moussavou André Délicat Philippe Yaba Dieudonné Nkoghe Jean-Paul Gonzalez Eric Maurice Leroy | 2005 | Microbes and Infection2005，，7： | 4 |
| 14 | 大鼠骨髓源内皮祖细胞的分离与鉴定显示文摘目的:建立大鼠骨髓源内皮祖细胞(EPCs)的分离与鉴定方法。方法:取大鼠双侧股骨和胫骨骨髓腔细胞,采用密度梯度离心法、组织淋巴细胞分离液分离单个核细胞,将细胞过滤离心后置于含20%FBS的DMEM低糖完全培养基中培养;采用流式细胞仪鉴定EPCs细胞表面标志物CD34、CD133及VEGFR2的表达。结果:细胞培养2 d后可观察到梭形的贴壁细胞,培养7 d后细胞呈克隆样集落,流式细胞仪鉴定为EPCs细胞的特征。结论:大鼠骨髓中可提取并分化出质量较好的EPCs细胞。 | Nganguem Nzalle Yranney Brice 林慕之 毛善永 张蓓 周海燕 胡柏龙 王艺明 况春燕 刘兴德 | 2020 | 贵州医科大学学报2020，45，3： | 3 |
| 15 | The 4th World Landslide Forum: Landslide Research and Risk Reduction for Advancing the Culture of Living with Natural Hazards显示文摘The World Landslide Forum is a triennial mainstream conference that gathers together the scientific and technological community, policymakers, industry actors, public officials, and other stakeholders, who deal with the understanding and management of landslide disaster risk. The establishment of the ISDR-ICL Sendai Partnerships 2015–2025 for Global Promotion of Understanding and Reducing Landslide Disaster Risk in Sendai during the 2015 World Conference on Disaster Risk Reduction(WCDRR) enabled the landslide science and technology community support the implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030 in order to prevent new and reduce existing disaster risk.The 4th World Landslide Forum(WLF4) was held in Ljubljana, Slovenia, from 29 May to 2 June 2017 and discussed the progress of landslide research and risk reduction for advancing the culture of living with natural hazards. A high-level panel composed of United Nations officials, international stakeholders, and national organizations sought to identify the best mechanisms to be developed by the community of the International Consortium on Landslides(ICL). The objective was to advance the implementation of the ISDR-ICL Sendai Partnerships,to achieve a better commitment among partners, and to provide substantive services to developing countries. During the WLF4, the 2017 Ljubljana Declaration on Landslide Risk Reduction was adopted and the concept framework of the Kyoto 2020 Commitment was endorsed. | Irasema Alcntara-Ayala Kyoji Sassa Matjaz Miko Quinli Han Jakob Rhyner Kaoru Takara Satoru Nishikawa Badaoui Rouhban Slvano Briceo | 2017 | International Journal of Disaster Risk Science2017，8，4： | 3 |
| 16 | Evaluation of stapler hepatectomy during a laparoscopic liver resection显示文摘 | Joseph F. Buell Brice Gayet Ho‐Seong Han Go Wakabayashi Ki‐Hun Kim Giulio Belli Robert Cannon Bob Saggi Hiro Keneko Alan Koffron Guy Brock Ibrahim Dagher | 2013 | HPB2013，，11： | 3 |
| 17 | Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease显示文摘 | Brice Sid Julien Verrax Pedro Buc Calderon | 2013 | Biochemical Pharmacology2013，，2： | 3 |
| 18 | Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum(Asteraceae) in male Wistar rats显示文摘Objective: Cyclophosphamide(CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract(AE) and methanolic extract(ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.Methods: In addition to a normal control(group 1), drugs or vehicles were administered orally to seven groups(n = 5) of rats that had already received 4-weeks of pre-treatment with CP(5 mg/[kgád], per oral administration);group 2 received CP + distilled water(10 m L/[kgád]);group 3 received CP + 5% tween 80(10 m L/[kgád]);group 4 received CP + clomiphene citrate(0.25 mg/[kgád]);groups 5 and 6 received CP + AE(50 and 100 mg/[kgád]) and groups 7 and 8 received CP + ME(50 and 100 mg/[kgád]). Animals were sacrificed on day 15, and body and sexual organ weights, sperm characteristics, testosterone level and testicular histology were evaluated.Results: The CP-treated group showed a significant reduction(P < 0.001) in the body and seminal vesicle weights, testosterone level, sperm count, sperm motility and sperm viability, but elevated(P < 0.001)sperm morphological abnormalities and testicular structure alterations, compared to the control group.Interestingly, these detrimental effects of CP were reversed by treatment with H. odoratissimum extracts.For instance, both extracts and all doses of H. odoratissimum significantly increased the sperm count(P < 0.001), sperm motility(AE, 50 mg/kg, P < 0.05;ME, 50 and 100 mg/kg, P < 0.05) and sperm viability(AE, 50 mg/kg, P < 0.001;ME, 50 and 100 mg/kg, P < 0.001) compared to the CP group. H. odoratissimum also improved plasmatic and intratesticular testosterone levels and prevented histological alterations of the testes.Conclusion: H. odoratissimum might be considered as an alternative drug to alleviate/prevent reproductive damage in cancer patients receiving CP chemotherapy. | Pierre Watcho Ismaelle Rosine Mpeck Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Georges Romeo Bonsou Fozin Pierre Kamtchouing Albert Kamanyi | 2019 | Journal of Integrative Medicine2019，17，5： | 3 |
| 19 | Geochemical constraints on the origin and tectonic setting of the serpentinized peridotites from the Paleoproterozoic Nyong series,Eseka area,SW Cameroon显示文摘Serpentinized rocks closely associated with Paleoproterozoic eclogitic metabasites were recently discovered at Eseka area in the northwestern edge of the Congo craton in southern Cameroon.Here,we present new field data,petrography,and first comprehensible wholerock geochemistry data and discuss the protolith and tectonic significance of these serpentinites in the region.The studied rock samples are characterized by pseudomorphic textures,including mesh microstructure formed by serpentine intergrowths with cores of olivine,bastites after pyroxene.Antigorite constitutes almost the whole bulk of the rocks and is associated(to the less amount)with tremolite,talc,spinel,and magnetite.Whole-rock chemistry of the Eseka serpentinites led to the distinction of two types.Type 1 has high MgO(>40 wt%)content and high Mg#values(88.80)whereas Type 2 serpentinite samples display relatively low MgO concentration and Mg#values(<40 and 82.88 wt%,respectively).Both types have low Al/Si and high Mg/Si ratios than the primitive mantle,reflecting a refractory abyssal mantle peridotite protolith.Partial melting modeling indicates that these rocks were derived from melting of spinel peridotite before serpentinization.Bulk rock high-Ti content is similar to the values of subducted serpentinites(>50 ppm).This similarity,associated with the high Cr contents,spinel-peridotite protolith compositions and Mg/Si and Al/Si ratios imply that the studied serpentinites were formed in a subductionrelated environment.The U-shaped chondrite normalizedREE patterns of serpentinized peridotites,coupled with similar enrichments in LREE and HFSE,suggest the refertilized nature due to melt/rock interaction prior to serpentinization.Based on the results,we suggest that the Eseka serpentinized peridotites are mantle residues that suffered a high degree of partial melting in a subductionrelated environment,especially in Supra Subduction Zone setting.These new findings suggest that the Nyong series in Cameroon represents an uncontested Paleoproterozoic suture zone between the Congo craton and the Sao Francisco craton in Brazil. | Philomene Nga Essomba Tsoungui Sylvestre Ganno Evine Laure Tanko Njiosseu Jean Lavenir Ndema Mbongue Brice Kamguia Woguia Landry Soh Tamehe Jonas Didero Takodjou Wambo Jean Paul Nzenti | 2020 | Acta Geochimica2020，39，3： | 3 |
| 20 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
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