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| 1 | Mesenchymal stromal cells from human perinatal tissues: From biology to cell therapy显示文摘Cell-based regenerative medicine is of growing interest in biomedical research. The role of stem cells in this context is under intense scrutiny and may help to define principles of organ regeneration and develop innovative therapeutics for organ failure. Utilizing stem and progenitor cells for organ replacement has been conducted for many years when performing hematopoietic stem cell transplantation. Since the first successful transplantation of umbilical cord blood to treat hematological malignancies, non-hematopoietic stem and progenitor cell populations have recently been identified within umbilical cord blood and other perinatal and fetal tissues. A cell population entitled mesenchymal stromal cells (MSCs) emerged as one of the most intensely studied as it subsumes a variety of capacities: MSCs can differentiate into various subtypes of the mesodermal lineage, they secrete a large array of trophic factors suitable of recruiting endogenous repair processes and they are immunomodulatory.Focusing on perinatal tissues to isolate MSCs, we will discuss some of the challenges associated with these cell types concentrating on concepts of isolation and expansion, the comparison with cells derived from other tissue sources, regarding phenotype and differentiation capacity and finally their therapeutic potential. | Karen Bieback Irena Brinkmann | 2010 | World Journal of Stem Cells2010，2，4： | 15 |
| 2 | Orosomucoid (ORM) typing by isoelectric focusing: description of two new alleles in a German population and thermostability in bloodstains显示文摘 | K. Umetsu I. Yuasa K. Nishi B. Brinkmann T. Suzuki | 1989 | Zeitschrift für Rechtsmedizin (-)1989，，2： | 3 |
| 3 | Animal phylogeny and large-scale sequencing: progress and pitfalls显示文摘Phylogenomics, the inference of phylogenetic trees using genome-scale data, is becoming the rule for resolving difficult parts of the tree of life. Its promise resides in the large amount of information available, which should eliminate stochastic error. However, systematic error, which is due to limitations of reconstruction meth-ods, is becoming more apparent. We will illustrate, using animal phylogeny as a case study, the three most effi-cient approaches to avoid the pitfalls of phylogenomics: (1) using a dense taxon sampling, (2) using probabilistic methods with complex models of sequence evolution that more accurately detect multiple substitutions, and (3) removing the fastest evolving part of the data (e.g., species and positions). The analysis of a dataset of 55 animal species and 102 proteins (25712 amino acid positions) shows that standard site-homogeneous model inference is sensitive to long-branch attraction artifact, whereas the site-heterogeneous CAT model is less so. The latter model correctly locates three very fast evolving species, the appendicularian tunicate Oikopleura, the acoel Convoluta and the myxozoan Buddenbrockia. Overall, the resulting tree is in excellent agreement with the new animal phylogeny, confirming that 'simple' organisms like platyhelminths and nematodes are not necessarily of basal emergence. This further emphasizes the importance of secondary simplification in animals, and for organismal evolution in general. | Henner BRINKMANN Herve PHILIPPE | 2008 | 植物分类学报2008，46，3： | 3 |
| 4 | Development of CO2 Selective Poly(Ethylene Oxide)-Based Membranes: From Laboratory to Pilot Plant Scale显示文摘气体膜分离法是从气流中分离二氧化碳(CO_2)的最有前途的技术之一。例如,采用该技术对燃烧过程中的烟气进行处理,以达到CO_2捕集和封存的目的。聚环氧乙烷嵌段共聚物能够很好地应用于膜分离技术,如Pebax~?或Poly Active^(TM)。本文采用Poly Active^(TM)作为复合薄膜的选择层。在环境温度下,当CO_2/N_2选择性超过55时,这种薄膜的CO_2渗透率高达4 m^3(STP)·m^(–2)·h^(–1)·bar^(–1)(注:1 bar=105 Pa)。这种薄膜可以按照中试规模进行生产放大,而且可以设计成不同的平面膜组件。采用单一气体渗透数据作为唯一的实验输入而开发出的仿真工具可以准确预测这种膜组件的性能。在不同的中试研究中,我们利用烟气和沼气作为原料气流,反复检测这些膜和膜组件的性能。Poly Active^(TM)在检测中显示出了稳定的分离性能,表明Poly Active^(TM)非常适用于作为膜材料进行工业规模气体处理。 | Torsten Brinkmann Jelena Lilleparg Heiko Notzke Jan Pohlmann Sergey Shishatskiy Jan Wind Thorsten Wolff | 2017 | Engineering2017，3，4： | 3 |
| 5 | Solid-state lasers project laser television signals显示文摘 | Brinkmann Uwe | 1997 | Laser Focus World WORLD NEWS1997，，11： | 2 |
| 6 | Next generation per-and poly-fluoroalkyl substances:Status and trends,aquatic toxicity,and risk assessment显示文摘Widespread application of poly-and per-fluoroalkyl substances(PFAS)has resulted in some substances being ubiquitous in environmental matrices.That and their resistance to degradation have allowed them to accumulate in wildlife and humans with potential for toxic effects.While specific substances of concern have been phased-out or banned,other PFAS that are emerging as alternative substances are still produced and are being released into the environment.This review focuses on describing three emerging,replacement PFAS:perfluoroethylcyclohexane sulphonate(PFECHS),6:2 chlorinated polyfluoroalkyl ether sulfonate(6:2 Cl-PFAES),and hexafluoropropylene oxide dimer acid(HFPO-DA).By summarizing their physicochemical properties,environmental fate and transport,and toxic potencies in comparison to other PFAS compounds,this review offers insight into the viabilities of these chemicals as replacement substances.Using the chemical scoring and ranking assessment model,the relative hazards,uncertainties,and data gaps for each chemical were quantified and related to perfluorooctane sulfonic acid(PFOS)and perfluorooctanoic acid(PFOA)based on their chemical and uncertainty scores.The substances were ranked PFOS>6:2 Cl-PFAES>PFOA>HFPO-DA>PFECHS according to their potential toxicity and PFECHS>HFPO-DA>6:2 Cl-PFAES>PFOS>PFOA according to their need for future research.Since future uses of PFAS remain uncertain in the face of governmental regulations and production bans,replacement PFAS will continue to emerge on the world market and in the environment,raising concerns about their general lack of information on mechanisms and toxic potencies. | Hannah Mahoney Yuwei Xie Markus Brinkmann John P.Giesy | 2022 | Eco-Environment & Health2022，1，2： | 2 |
| 7 | Neutrophil extracellular traps: Is immunity the second function of chromatin?显示文摘 | Volker Brinkmann Arturo Zychlinsky | 2012 | The Journal of Cell Biology2012，，5： | 2 |
| 8 | Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells显示文摘AIM: To present an approach for selectively killing retrovirus-infected cells that combines the toxicity of Pseudomonas exotoxin (PE) and the presence of reverse transcriptase (RT) in infected cells. METHODS: PE antisense toxin RNA has palindromic stem loops at its 5' and 3' ends enabling self-primed generation of cDNA in the presence of RT. The RT activity expressed in retrovirus-infected cells converts 'antisense-toxin-RNA' into a lethal toxin gene exclusively in these cells. RESULTS: Using cotransfection studies with PE-expressing RNAs and β-gal expressing reporter plasmids, we show that, in HepG2 and HepG2.2.15 hepatoma cells as well as in duck hepatitis B virus (DHBV) infected cells, HBV or DHBV-polymerase reverse transcribe a lethal cDNA copy of an antisense toxin RNA, which is composed of sequences complementary to a PE gene and eukaryotic transcription and translation signals. CONCLUSION: This finding may have important implications as a novel therapeutic strategy aimed at the elimination of HBV infection. | Peter Hafkemeyer Ulrich Brinkmann Elizabeth Brinkmann Ira Pastan Hubert E Blum Thomas F Baumert | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 9 | FTY720:mechanism of action and potential benefit in organ transplantation显示文摘 | Brinkmann V | 2004 | Yonsei Med J2004，45，6： | 1 |
| 10 | Origin and diversity of metabolically active gut bacteria from laboratory-bred larvae of Manduca sexta 显示文摘 | Brinkmann N Martens R Tebbe C C | 2008 | Appl Environ Microbiol2008，74，23： | 1 |
| 11 | Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors显示文摘 | Siegsmund M Brinkmann U Scháffeler E Weirich G Schwab M Eichelbaum M | 2002 | J Am Soc Nephrol2002，13，7： | 1 |
| 12 | Iridiumcatalyzed enantioselective hydrogenation of Imines in supercritical carbon dioxide显示文摘 | Brinkmann A Leitner W Pfaltz A | 1999 | J Am Chem Soc1999，121，： | 1 |
| 13 | UNC93B1 delivers nucleotide-sensing Toll-like receptors to endolysosomes显示文摘 | Kim YM Brinkmann MM Paquet ME | 2008 | Nature2008，452，7184： | 1 |
| 14 | Mutation rate in human microsatellites: influence of the structure and lengthof the tandem repeat 显示文摘 | Brinkmann B Klintschar M Neuhuber F | 1998 | Am J Hum Genet1998，62，6： | 1 |
| 15 | DNA Commission of the ISFG (International Society of Forensic Genetics):recommendations on forensic analysis using Y-chromosome STRs显示文摘 | Gill P Brenner C Brinkmann B | 2001 | Int J Legal Med2001，114，6： | 1 |
| 16 | Frequency of C3435T polymorphism of MDR1 gene in African people显示文摘 | Schaeffeler E Eichelbaum M Brinkmann U Penger A Asante-Poku S Zanger UM | 2001 | Lancet2001，358，9279： | 1 |
| 17 | Sphingosine l-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: Association with prolonged allograft survival显示文摘 | Lan YY Tokita D Wang Z Wang HC Zhan J Brinkmann V | 2008 | Trans Immunol2008，20，12： | 1 |
| 18 | Skeletal involvement and fbllow-up in linear nevus sebaceous syndrome 显示文摘 | Muhle C Brinkmann G Muhle K Heller M | 1998 | Eur Radiol1998，8，4： | 1 |
| 19 | The interaction between the ER membrane protein UNC93B and TLR3, 7and 9 is crucial for TLR signaling显示文摘 | Brinkmann MM | 2007 | Cell Biol2007，177，2： | 1 |
| 20 | Vasopressin administration in refractory cardiac arrest显示文摘 | Lindner KH Prengel AW Brinkmann A | 1996 | Ann Intern Med1996，124，12： | 1 |
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