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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights显示文摘 | Amir Abbas Samani Shoshana Yakar Derek LeRoith Pnina Brodt | 2007 | Endocrine Reviews2007，，1： | 6 |
| 3 | The Effects of Screw Length on Stability of Simulated Osteoporotic Distal Radius Fractures Fixed With Volar Locking Plates显示文摘 | Lindley B. Wall Michael D. Brodt Matthew J. Silva Martin I. Boyer Ryan P. Calfee | 2012 | Journal of Hand Surgery2012，，3： | 2 |
| 4 | Identification of a novel coronavirus in patients with severe acute respiratory syndrome显示文摘 | Drosten C Gunther S Preiser W van der Werf S Brodt HR Becker S | 2003 | N Engl J Med2003，348，： | 1 |
| 5 | Inhaled antibiotics for stable non-cystic fibrosis bronchiectasis:a systematic review显示文摘 | Brodt AM Stovold E Zhang L | 2014 | Eur Respir J2014，44，2： | 1 |
| 6 | Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3- kinase/Aky signaling 显示文摘 | Zhang D Brodt P | 2003 | Oncogene2003，22，7： | 1 |
| 7 | The role of the IGF system in cancer growth and metastasis:overview and re- cent insights 显示文摘 | Samani AA YS LeRoith D Brodt P | 2007 | Endocr Rev2007，28，1： | 1 |
| 8 | Type Ⅰ insulin-like growth regulates MT1-MMP synthesis and tumor invasion via PI3-kinase/Akt signaling显示文摘 | ZHANG D BRODT P | 2003 | Oncogene2003，22，7： | 1 |
| 9 | Attenuated re-sponse to in vivo mechanical loading in mice with conditional oste-oblast ablation of the connexin43 gene ( Gjal ) 显示文摘 | GRIMSTON S K BRODT M D SILVA M J | 2008 | J Bone MinerRes2008，23，6： | 1 |
| 10 | The role of the insulin like growth factor- I receptor in malignancy:an update显示文摘 | Seccareccia E Brodt P | 2012 | Growth Horm IGF Res2012，22，6： | 1 |
| 11 | Inhibition of the type 1 insulin - like growth factor receptor expression and signaling:novel strategies for antimetastatic therapy 显示文摘 | BRODT P SAMANI A NAVAB R | 2000 | Biochem Pharmacol2000，60，： | 1 |
| 12 | Minimizing radiation dose for pediatric body application of single detector helical CT: strategies at a large Children's hospital 显示文摘 | Donnelly LE Emery KH Brodt AS | 2001 | ARJ2001，176，： | 1 |
| 13 | Managers asinitiators of trust: An exchange relationship frame work forunderstanding managerial trustworthy behavior 显示文摘 | Whitener E M Brodt S E Korsgaard M A | 1998 | Academy ofManagement Review1998，23，3： | 1 |
| 14 | Identification of a novel coronavirus in patients with severe acute respiratory syndrome显示文摘 | Gunther S Preiser W van der Weft S Brodt HR Becker S Rabenau H Panning M Kolesnikova L Fouchier RA Berger A Burguiere AM Cinatl J Eickmann M Escriou N Grywna K Kramme S Manuguerra JC Muller S Rickerts V Sturmer M Vieth S Klenk HD Osterhaus AD Schmitz H Doerr HW | 2003 | N Engl J Med2003，348，： | 1 |
| 15 | Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI3-kinase/Akt signaling显示文摘 | Zhang D Brodt P | 2003 | Oncogene2003，22，7： | 1 |
| 16 | Mechanical behavior of human morselized cancellous bone in triaxial compression显示文摘 | Brodt MD Swan CC Brown TD | 1998 | J Orthop Res1998，16，： | 1 |
| 17 | Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis显示文摘 | Brodt P Fallavollital L Robert S | 1997 | Int J cancer1997，71，4： | 1 |
| 18 | Temporal relationshipof conduction system disease and ventricular dysfunction in LMNAcardiomyopathy显示文摘 | Brodt C Siegfried JD Hofmeyer M | 2013 | J Card Fail2013，19，： | 1 |
| 19 | Mechanical behavior of human morselized cancellous bone in triaxial compression testing 显示文摘 | Brodt MD Swan CC Brown TD | 1998 | J Orthop Res1998，16，： | 1 |
| 20 | Impaired marrow osteogenesis is associated with reduced endocortical bone formation but does not impair pefiosteal boone formation in long bones of SAMP6 mice 显示文摘 | Silva M J Brodt MD Abu - Amer Y | 2005 | J Bone Miner Res2005，20，： | 1 |
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